The value of transperineal apical prostate biopsy in predicting urethral/apical margin status after radical prostatectomy

Dai, Jindong; Zhang, Xingming; Zhao, Jinge; Sun, Guangxi; Chen, Junru; Liu, Jiandong; Tao, Ronggui; Zeng, Hao; Shen, Pengfei

doi:10.1097/md.0000000000017633

Cited by 3 publications

(2 citation statements)

References 34 publications

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“…Local anesthetic transperineal prostate biopsy (LATP) is a widely accepted and well-tolerated procedure for diagnosing prostate cancer. It offers several advantages over traditional TR biopsy, including reduced infection and sepsis risk, improved sampling of the apical and anterior prostate regions, and potentially higher cancer detection rates [4][5][6]. Among men under active surveillance for low-risk prostate cancer, LATP is more adept at identifying clinically significant cases, likely due to improved sampling of the anterior prostate region [7].…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Incidence of Infection Following Local Anesthetic Transperineal Prostate Biopsy: A Single-Centre Experience

Khalabazyane,

Mizzi,

Rashid

et al. 2024

Cureus

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BackgroundLocal anesthetic transperineal prostate biopsy (LATP) is a widely used diagnostic procedure for prostate cancer. As a diagnostic procedure, it should carry minimal risk. However, morbidity resulting from prostate biopsy is frequent. Prostate biopsy, like any other intervention, carries a significant risk of various infections, ranging from urinary tract infections (UTIs) to potentially life-threatening conditions like sepsis. AimThis study examined the rate of infections following a prostate biopsy at a single center and sought to identify risk factors that could increase the likelihood of developing an infection. MethodsA retrospective review was conducted on all 168 patients who underwent LATP biopsy between 01/04/2022 and 01/04/2023. Data were collected from the Clinical Record and Reporting System (CRRS). Patient characteristics, including age, prostate-specific antigen (PSA) levels, prostate volume, the main indication for the biopsy, number of cores taken, antibiotic prophylaxis, and comorbidities were analyzed. The inclusion criteria encompassed all patients receiving this procedure within the specified timeframe, without restrictions on age, underlying health conditions, or medical history. No exclusion criteria were applied, aiming to comprehensively analyze and capture the full spectrum of patient outcomes and characteristics associated with these biopsies during the study period. ResultsIn terms of socio-demographics, all patients were male with an average age (mean) of 65.5 years, a mean PSA level of 13.9 ng/dL, and an average prostate volume of 66.1 mL. On average, 23.2 biopsy cores were taken. All patients received antibiotic prophylaxis, mainly ciprofloxacin. Despite this, 1.78% of patients (n=3) developed post-biopsy infections. Two of these patients had diabetes mellitus, and two had a large prostate volume of 95 mL.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Incidence of Infection Following Local Anesthetic Transperineal Prostate Biopsy: A Single-Centre Experience

Khalabazyane,

Mizzi,

Rashid

et al. 2024

Cureus

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Clinicopathological implications of histological mapping in radical prostatectomy specimens

Cho

Pyo

Kim

et al. 2023

Pathology - Research and Practice

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Clinicopathological Significances of Positive Surgical Resection Margin after Radical Prostatectomy for Prostatic Cancers: A Meta-Analysis

et al. 2022

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Background and Objectives: This study aims to elucidate the positive rate and the clinicopathological significance of surgical margin after radical prostatectomy (RP) through a meta-analysis. Materials and Methods: This meta-analysis finally used 59 studies, including the information about the positive surgical margin (PSM) and those clinicopathological significances after RP. The subgroup analysis for the estimated rates of PSM was evaluated based on types of surgery, grade groups, and pathological tumor (pT) stages. We compared the clinicopathological correlations between positive and negative surgical margins (NSM). Results: The estimated PSM rate was 25.3% after RP (95% confidence interval [CI] 21.9–29.0%). The PSM rates were 26.0% (95% CI 21.5–31.1%) 28.0% (95% CI 20.2–37.5%) in robot-assisted RP and nerve-sparing RP, respectively. The PSM rate was significantly higher in high-grade groups than in low-grade groups. In addition, the higher pT stage subgroup had a high PSM rate compared to the lower pT stage subgroups. Patients with PSM showed significantly high PSA levels, frequent lymphovascular invasion, lymph node metastasis, and extraprostatic extension. Biochemical recurrences (BCRs) were 28.5% (95% CI 21.4–36.9%) and 11.8% (95% CI 8.1–16.9%) in PSM and NSM subgroups, respectively. Patients with PSM showed worse BCR-free survival than those with NSM (hazard ratio 2.368, 95% CI 2.043–2.744%). Conclusions: Our results showed that PSM was significantly correlated with worse clinicopathological characteristics and biochemical recurrence-free survival. Among the results in preoperative evaluations, grade group and tumor stage are useful for the prediction of PSM.

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The value of transperineal apical prostate biopsy in predicting urethral/apical margin status after radical prostatectomy

Abstract: Supplemental Digital Content is available in the text

Cited by 3 publications

References 34 publications

Incidence of Infection Following Local Anesthetic Transperineal Prostate Biopsy: A Single-Centre Experience

Incidence of Infection Following Local Anesthetic Transperineal Prostate Biopsy: A Single-Centre Experience

Clinicopathological implications of histological mapping in radical prostatectomy specimens

Clinicopathological Significances of Positive Surgical Resection Margin after Radical Prostatectomy for Prostatic Cancers: A Meta-Analysis

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