The value of Tzanck smear test in diagnosis of erosive, vesicular, bullous, and pustular skin lesions

Durdu, Murat; Baba, Mete; Seckın, Denız

doi:10.1016/j.jaad.2008.07.059

Cited by 90 publications

(107 citation statements)

References 20 publications

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“…Light microscopy has the advantage of being inexpensive, rapid, and simple to perform (13). It also enables simultaneous screening for other pathologies, such as bullous impetigo, candidiasis, or pemphigus (14). This method can be utilized for diagnosis of HSV infection in a wide variety of other clinical specimens, ranging from cervical brushings to surgical specimens (12).…”

Section: Methods For Detection Of Hsvmentioning

confidence: 99%

“…Sensitivity is also affected by the stage of the lesion, with the highest positivity rate being observed in early vesicular lesions (10). Even given proper sampling of vesicular lesions, a study by Durdu et al reported a sensitivity of 84.7% in a comparison with serology and clinical findings (14). Another drawback of light microscopy is a lack of specificity.…”

Section: Methods For Detection Of Hsvmentioning

confidence: 99%

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Light Microscopy, Culture, Molecular, and Serologic Methods for Detection of Herpes Simplex Virus

2014

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Herpes simplex virus 1 (HSV-1) and 2 (HSV-2) cause a variety of human diseases, ranging from acute to chronic and mild to severe. The absence of curative therapy results in lifelong carriage marked by recurrent outbreaks and allows transmission of the virus to uninfected individuals. Nonspecific lesions, variable presentation, and chronic carriage necessitate the use of different laboratory testing methods appropriate for each presentation. A thorough understanding of the performance characteristics and limitations of available tests is critical for selection of the appropriate test and interpretation of results. Clinical sensitivity, specificity, and selection of the appropriate methodology is paramount to avoid misdiagnosis and guide therapy. In this article we review the different methods for detection and typing of HSV, including light microscopy, culture, serology, and nucleic acid-based tests. We discuss the strengths and weaknesses of each method for diagnosing HSV infection, cite performance characteristics, and review appropriate clinical uses.

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Section: Methods For Detection Of Hsvmentioning

confidence: 99%

Section: Methods For Detection Of Hsvmentioning

confidence: 99%

Light Microscopy, Culture, Molecular, and Serologic Methods for Detection of Herpes Simplex Virus

2014

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“…When there was a vesicle, bulla, or pustule, the intact roof of the lesion was incised along one side and folded back, and the base of the lesion was then gently scraped with a scalpel. Scrapings of the erosive lesions were also obtained (6). The obtained cellular materials were then spread as a thin layer onto at least two microscopic slides and air-dried.…”

Section: Preparation Of Tzanck Smearsmentioning

confidence: 99%

“…Our study that investigated the diagnostic value of the Tzanck smear test in erosive vesiculobullous, granulomatous, and pigmented skin lesions has been published (6)(7)(8). In this study, our aim was to report the cytologic findings in patients who had skin lesions showing abundant eosinophils in cytologic examination.…”

Section: Introductionmentioning

confidence: 99%

Cytologic Findings of Eosinophilic Dermatoses: a Retrospective Analysis of 88 Patients

Durdu¹

2016

tdd

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Objectives: Eosinophilic skin infiltration may develop as a result of a variety of infectious, inflammatory, and neoplastic diseases. To distinguish these diseases histopathologic examination is usually considered. So far, only a few studies have investigated cytologic findings of some eosinophilic diseases. In this retrospective study, our aim was to define the cytologic findings of eosinophilic dermatoses and to develop an algorithmic approach based on the cytologic findings. Methods: Patients who applied to the dermatology polyclinic through January 2010 to January 2015 could not be diagnosed only by clinical examination were further evaluated with May-Grunwald-Giemsa-stained preparations by a dermatologist. Patients with abundant eosinophils in microscopic examination were included in this study. After routine cytologic examination additional staining was also performed in some of these patients. The final diagnosis was established according to their clinical laboratory and histopathologic findings. Results: Over a 5-year period, 88 of 3.214 patients (2.7%) who underwent cytologic examination at our center had plenty of eosinophils. According to the final diagnoses, 44 lesions (50%) were spongiotic dermatitis, 17 lesions (19.3%) were infectious diseases, 13 lesions (14.8%) were autoimmune bullous, 11 lesions (12.5%) were idiopathic eosinophilic diseases, and 3 lesions (3.4%) were granulomatous diseases. Conclusion: Cytologic examination of people with eosinophilic skin diseases cytologic findings accompanying eosinophils could help for diagnosis of some diseases. Keywords: Cytology, dermatitis, eosinophils, eosinophilic pustular folliculitis, eosinophilic cellulitis, pemphigus Murat Durdu

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“…Tzanck yayması: Oral ülserlerin ayırıcı tanısında ucuz ve hızlı bir başucu testidir 5 . Oral kavitede sözü edilen erozyon veya ülserlerin tabanından, bir tahta spatula veya fırça yardımıyla alınan kazıntı materyali lama yayılıp Giemsa ile boyanır.…”

Section: Oral Erozyon Ve üLserlerin Laboratuvar Tanısıunclassified

Oral Mukozanın Erozif, Ülseratif, Veziküler ve Büllöz Lezyonları

...

2012

Turkderm

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ÖzetOral kavite mukozasında gelişen erozif ve ülseratif lezyonlar, hastaların günlük yaşamını ve yaşam kalitesini doğrudan etkileyen ve klinik pratikte sıkça karşılaşılan yakınma nedenleridir. Bu lezyonlar, bazen mortalitesi olan önemli bir deri hastalığının öncü bulgusu veya multisistemik bir hastalığın önemli bir belirtisi ya da bir malignitenin işaret bulgusu olarak karşımıza çıkabilir. Dolayısıyla erozyon ya da ülserler oral kavitenin dikkatli ve ayrıntılı klinik yaklaşım gerektiren önemli lezyonlarıdır. Bu makalede, oral kavite mukozasında erozyon veya ülsere yol açabilen çok sayıda hastalık içerisinden, günlük pratikte en sık karşılaştıklarımıza tanısal yaklaşımlar, algoritma şemaları yardımıyla aktarılmaya çalışılmıştır. Sum maryThe erosions and ulcers located on mucous membranes of oral cavity are complaints encountered frequently in our clinical practice which directly affect the life quality of patients. These lesions may be first signs of a disease with high mortality risk or presenting sign of a multisystemic disease or a cancer. Consequently, the erosions or ulcers of oral cavity are important lesions which need careful and detailed clinical evaluations. In this article, it was focused on algorithmic differential diagnosis of the diseases causing oral ulcers. Gi riflOral kavite mukozasında gelişen erozif (genellikle veziküler ve büllöz lezyonlara ikincil olarak) ve ülseratif lezyonlar, konuşma sırasında, yeme, çiğneme, (hatta bazen sıvı gıdaların alımında bile) ağrıya (odinofaji) yol açarak hastanın günlük yaşamını ve yaşam kalitesini doğrudan etkileyen ve klinik pratikte sıkça karşılaşılan yakınma nedenleridir. Bu lezyonlar, bazen pemfigus vulgaris gibi mortalitesi olan önemli bir deri hastalığının öncü bulgusu veya Behçet hastalığı gibi multisistemik bir hastalığın olmazsa olmaz belirtisi ya da bir malignitenin işaret bulgusu olarak karşımıza çıkabilir. Dolayısıyla erozyon ya da ülserler, oral kavitenin dikkatli ve ayrıntılı klinik yaklaşım gerektiren önemli lezyonlarıdır 1 .Oral muköz membranlar oral kaviteye özelleşmiş frajil membranlar olup, erozyon (epitelde yüzeysel kayıp) ve ülser (epitelde lamina propriyaya kadar tüm katlar boyunca kayıp) gelişimi açısından duyarlı yapılardır 2,3 . Oral kavitede gelişen erozyon ve ülseri klinik olarak ayırt etmek çoğu zaman zordur ve genellikle pratikte birbirlerinin yerine sıkça kullanılırlar. Bu lezyonların etyolojisinde küçük travmalardan, malignitelere ve sistemik hastalıklara kadar uzanan geniş bir yelpaze içerisinde çok sayıda hastalıktan söz edilebilir. Genel olarak oral ülserler ağrılı olup tek ya da çok sayıda, simetrik veya düzensiz şekilli ülserlerdir. Genellikle parlak eritemli bir halo ile çevrili olan ülserin tabanı frajil, sarımsı-beyaz renkte bir eksüdasyonla kaplıdır. Akut bir ülser oluştuğu andan itibaren oral kavite mikroflorası ve tükrüğün sürekli olarak irritasyonuna maruz kalır ve akut inflamatuar www.turk derm.org.tr

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The value of Tzanck smear test in diagnosis of erosive, vesicular, bullous, and pustular skin lesions

Cited by 90 publications

References 20 publications

Light Microscopy, Culture, Molecular, and Serologic Methods for Detection of Herpes Simplex Virus

Light Microscopy, Culture, Molecular, and Serologic Methods for Detection of Herpes Simplex Virus

Cytologic Findings of Eosinophilic Dermatoses: a Retrospective Analysis of 88 Patients

Oral Mukozanın Erozif, Ülseratif, Veziküler ve Büllöz Lezyonları

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