The value of walking: a systematic review on mobility and healthcare costs

Wohlrab, Martin; Klenk, Jochen; Delgado-Ortiz, Laura; Chambers, Michael; Rochester, Lynn; Zuchowski, Matthias; Schwab, Matthias; Becker, Clemens; Jaeger, Simon U.

doi:10.1186/s11556-022-00310-3

Cited by 10 publications

(10 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Consistent information supports the idea that building walking and cycling track networks is beneficial to society in terms of air pollution, public transport, and health population 10 . For healthcare costs, cross-sectional studies have described an inverse relationship between engagement in walking and lower healthcare costs 8 , 11 , 12 , 13 , whereas few studies address the economic impact attributed to cycling 14 . Although walking and cycling are common and accessible forms of transportation among adults 7 , 15 , aging leads to reduction in both behaviors, while increasing chronic diseases occurrence and healthcare costs 4 , 15 , 16 , especially after the fifth decade of life 4 , 17 , placing this portion of the population at increased risk and raising questions on how walking and cycling could be beneficial in reducing costs.…”

Section: Introductionmentioning

confidence: 99%

Impact of cycling and walking on adiposity and healthcare costs among adults: longitudinal study

Orbolato,

Fernandes,

Turi-Lynch

et al. 2024

Cad. Saúde Pública

View full text Add to dashboard Cite

Leisure-time physical activity seems relevant to prevent the development of chronic diseases and obesity. However, not much is known about the economic burden of these healthy behaviors, mainly in longitudinal designs. This study aimed to analyze the impact of walking and cycling on leisure-time on adiposity and healthcare costs among adults. This longitudinal study was conducted at a medium-size Brazilian city and included 198 participants with no missing data attended in the Brazilian Unified National Health System. Cycling and walking were assessed by a questionnaire with a face-to-face interview at four time-points (baseline, 6-month, 12-month, and 18-month). Healthcare costs were assessed using medical records. Adiposity markers included waist circumference and body fatness. Over the follow-up period, participants who were more engaged in cycling presented lower body fatness (p-value = 0.028) and healthcare costs (p-value = 0.038). However, in the multivariate model, the impact of cycling on costs was not significant (p-value = 0.507) due to the impact of number of chronic diseases (p-value = 0.001). Cycling on leisure-time is inversely related to adiposity in adults, whereas its role on preventing chronic diseases seems the main pathway linking it to cost mitigation.

show abstract

Section: Introductionmentioning

confidence: 99%

Impact of cycling and walking on adiposity and healthcare costs among adults: longitudinal study

Orbolato,

Fernandes,

Turi-Lynch

et al. 2024

Cad. Saúde Pública

View full text Add to dashboard Cite

show abstract

“…10,11 For society, walking can effectively reduce healthcare costs. 12 However, most of the previous studies were small-scale clinical intervention studies or observational studies, and the evidence had certain limitations, such as limited samples, lack of speci city, and lack of clear causality. In this study, we employed a Mendelian randomization (MR) approach to investigate the causal relationship between various walking conditions, including walking speed, walking duration, 4week walking frequency, and Epigenetic Aging Acceleration (EAA) at the genetic level.…”

Section: Introductionmentioning

confidence: 99%

Effects of walking on epigenetic age acceleration: a Mendelian randomization study

Chen,

Liu,

Xia

et al. 2024

Preprint

View full text Add to dashboard Cite

Introduction : Walking stands as the most prevalent physical activity in the daily lives of individuals and is closely associated with physical functioning and the aging process. Nonetheless, the precise cause-and-effect connection between walking and aging remains unexplored. The epigenetic clock emerges as the most promising biological indicator of aging, capable of mirroring the biological age of the human body and facilitating an investigation into the association between walking and aging. Our primary objective is to investigate the causal impact of walking with epigenetic age acceleration (EAA). Methods We conducted a two-sample two-way Mendelian randomization (MR) study to investigate the causal relationship between walking and EAA. Walking and Leisure sedentary behaviour data were sourced from UK Biobank, while EAA data were gathered from a total of 28 cohorts. The MR analysis was carried out using several methods, including the inverse variance weighted (IVW), weighted median, MR-Egger, and Robust Adjusted Profile Score (RAPS). To ensure the robustness of our findings, we conducted sensitivity analyses, which involved the MR-Egger intercept test, Cochran’s Q test, and MR-PRESSO, to account for and mitigate potential pleiotropy. Results The IVW MR results indicate a significant impact of usual walking pace on GrimAge (BETA = -1.84, 95% CI (-2.94, -0.75)), PhenoAge (BETA = -1.57, 95% CI (-3.05, -0.08)), Horvath (BETA = -1.09 (-2.14, -0.04)), and Hannum (BETA = -1.63, 95% CI (-2.70, -0.56)). Usual walking pace is significantly associated with a delay in Epigenetic Aging Acceleration (EAA) (P < 0.05). Moreover, the direction of effect predicted by the gene remained consistent across RAPs outcomes and sensitivity MR Analyses. There is a lack of robust causal relationships between other walking conditions, such as walking duration and walking frequency, on EAA (P > 0.05). Conclusion Our evidence demonstrates that a higher usual walking pace is associated with a deceleration of the acceleration of all four classical epigenetic clocks acceleration.

show abstract

“…However, the automated analytic tools employed for many commercially available devices focus nearly exclusively on healthy younger adults and do not account for the impairments observed in older adults during device development or validation 9,10 . Hence, there is an urgent need for the development and validation of automated tools to quantify daily living gait among the full health spectrum of older adults that reside in the community-setting 11,12 .…”

Section: Introductionmentioning

confidence: 99%

Automated Gait Detection in Older Adults during Daily-Living using Self-Supervised Learning of Wrist- Worn Accelerometer Data: Development and Validation of ElderNet

Brand,

Kluge,

Palmerini

et al. 2024

Preprint

Self Cite

View full text Add to dashboard Cite

Progressive gait impairment is common in aging adults. Remote phenotyping of gait during daily living has the potential to quantify gait alterations and evaluate the effects of interventions that may prevent disability in the aging population. Here, we developed ElderNet, a self-supervised learning model for gait detection from wrist-worn accelerometer data. Validation involved two diverse cohorts, including over 1,000 participants without gait labels, as well as 83 participants with labeled data: older adults with Parkinson's disease, proximal femoral fracture, chronic obstructive pulmonary disease, congestive heart failure, and healthy adults. ElderNet presented high accuracy (96.43 ± 2.27), specificity (98.87 ± 2.15), recall (82.32 ± 11.37), precision (86.69 ± 17.61), and F1 score (82.92 ± 13.39). The suggested method yielded superior performance compared to two state-of-the-art gait detection algorithms, with improved accuracy and F1 score (p < 0.05). In an initial evaluation of construct validity, ElderNet identified differences in estimated daily walking durations across cohorts with different clinical characteristics, such as mobility disability (p < 0.001) and parkinsonism (p < 0.001). The proposed self-supervised gait detection method has the potential to serve as a valuable tool for remote phenotyping of gait function during daily living in aging adults.

show abstract

The value of walking: a systematic review on mobility and healthcare costs

Cited by 10 publications

References 38 publications

Impact of cycling and walking on adiposity and healthcare costs among adults: longitudinal study

Impact of cycling and walking on adiposity and healthcare costs among adults: longitudinal study

Effects of walking on epigenetic age acceleration: a Mendelian randomization study

Automated Gait Detection in Older Adults during Daily-Living using Self-Supervised Learning of Wrist- Worn Accelerometer Data: Development and Validation of ElderNet

Contact Info

Product

Resources

About