The value of whole-body dual-energy x-ray absorptiometry in assessing body composition in patients with inflammatory bowel disease: a prospective study

Nguyen, Anke L.; Herath, Madhuni; Burns, Megan; Holt, Darcy; Ebeling, Peter R.; Milat, Frances; Gibson, Peter R.; Moore, Gregory T.

doi:10.1097/meg.0000000000002675

Cited by 2 publications

(1 citation statement)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They found that ultrasound was the most accurate method for measuring muscle mass compared to BIA and DXA. Furthermore, they discovered that ultrasound had the highest level of agreement with the DXA-derived muscle mass index compared to BIA [ 47 ]. Ultrasound is indeed gaining popularity in the assessment of sarcopenia.…”

Section: Diagnostic Methods To Identify Sarcopenia In Ibd Patientsmentioning

confidence: 99%

Navigating the Intersection: Sarcopenia and Sarcopenic Obesity in Inflammatory Bowel Disease

Calvez,

Becherucci,

Covello

et al. 2024

Biomedicines

View full text Add to dashboard Cite

Inflammatory bowel diseases (IBDs) are intricate systemic conditions that can extend beyond the gastrointestinal tract through both direct and indirect mechanisms. Sarcopenia, characterized by a reduction in muscle mass and strength, often emerges as a consequence of the clinical course of IBDs. Indeed, sarcopenia exhibits a high prevalence in Crohn’s disease (52%) and ulcerative colitis (37%). While computed tomography and magnetic resonance imaging remain gold-standard methods for assessing muscle mass, ultrasound is gaining traction as a reliable, cost-effective, and widely available diagnostic method. Muscle strength serves as a key indicator of muscle function, with grip strength test emerging nowadays as the most reliable assessment method. In IBDs, sarcopenia may arise from factors such as inflammation, malnutrition, and gut dysbiosis, leading to the formulation of the ‘gut–muscle axis’ hypothesis. This condition determines an increased need for surgery with poorer post-surgical outcomes and a reduced response to biological treatments. Sarcopenia and its consequences lead to reduced quality of life (QoL), in addition to the already impaired QoL. Of emerging concern is sarcopenic obesity in IBDs, a challenging condition whose pathogenesis and management are still poorly understood. Resistance exercise and nutritional interventions, particularly those aimed at augmenting protein intake, have demonstrated efficacy in addressing sarcopenia in IBDs. Furthermore, anti-TNF biological therapies showed interesting outcomes in managing this condition. This review seeks to furnish a comprehensive overview of sarcopenia in IBDs, elucidating diagnostic methodologies, pathophysiological mechanisms, and clinical implications and management. Attention will also be paid to sarcopenic obesity, exploring the pathophysiology and possible treatment modalities of this condition.

show abstract

Section: Diagnostic Methods To Identify Sarcopenia In Ibd Patientsmentioning

confidence: 99%

Navigating the Intersection: Sarcopenia and Sarcopenic Obesity in Inflammatory Bowel Disease

Calvez,

Becherucci,

Covello

et al. 2024

Biomedicines

View full text Add to dashboard Cite

show abstract

Review article: Evidence‐based dietary management of inflammatory bowel disease

Gibson,

Yao,

Halmos

2024

Aliment Pharmacol Ther

View full text Add to dashboard Cite

SummaryBackgroundDietary management of patients with inflammatory bowel disease (IBD) involves more than defining a therapeutic diet. The profusion of ‘expert advice’ is not necessarily built on evidence.AimsTo provide evidence‐based guidance on all clinically relevant aspects of nutritional and dietary management of patients with IBD.MethodsA comprehensive review of the published literature was made.ResultsFour pillars of management should be considered in all patients. First, nutritional status should be optimised, since myopenia and visceral obesity are associated with poorer outcomes, which can be improved with attention to their correction. Accurate point‐of‐care measurement of body composition is advocated to identify problems, guide interventions and monitor outcomes. Second, exclusive enteral nutrition and the Crohn's Disease Exclusion Diet with partial enteral nutrition in reducing intestinal inflammation in patients with Crohn's disease have sufficient evidence to be advocated. Multiple other dietary approaches, while promising, have insufficient evidence to be recommended. Third, dietary approaches are important in symptomatic control in many non‐inflammatory scenarios. Finally, guidance on following a healthy diet is fundamental to the general health of patients. Multiple approaches are advocated, but the optimal strategy is unclear. The precarious nutritional status of patients with IBD together with the risks of nutritional inadequacy and maladaptive eating behaviours associated with restrictive diets dictate involvement of expert dietitians in assessment and personalised delivery of dietary interventions.ConclusionsFour pillars of nutritional management require specific assessment and interventional strategies that should be chosen by evidence. Optimal delivery requires the skills of a specialised dietitian.

show abstract

The value of whole-body dual-energy x-ray absorptiometry in assessing body composition in patients with inflammatory bowel disease: a prospective study

Cited by 2 publications

References 36 publications

Navigating the Intersection: Sarcopenia and Sarcopenic Obesity in Inflammatory Bowel Disease

Navigating the Intersection: Sarcopenia and Sarcopenic Obesity in Inflammatory Bowel Disease

Review article: Evidence‐based dietary management of inflammatory bowel disease

Contact Info

Product

Resources

About