The Values of Some Plasma Components During the Early Phases of Fracture Healing in Man

Lyritis, George P.; Nikiforidis, P.; Papadopoulou, Z.; Castrisios, E.; Hartofilakidis-Garofalidis, G.

doi:10.3109/17453677608991988

Cited by 5 publications

(4 citation statements)

References 12 publications

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“…Moreover, expression levels of TGFB , BMP2 , BMP4 , PDGFB and FGF2 was highest during the first 3 days post-fracture. The variation encountered in these elderly fragility fracture patients is similar to the findings obtained in animal models studies [8] and in healthy younger subjects [18] where the inflammatory phase occurs before day 3 post-fracture, being IL-6 a crucial player in this early phase of fracture healing.…”

Section: Discussionsupporting

confidence: 80%

“…On the other hand, ALP , a marker for osteoblast activity, decreases from early stages of bone healing. This gene expression profile had been already observed in other studies [18], [21], [22] and it is not entirely surprising, since this enzyme is involved in bone matrix production and our study is focused on the early changes related to fracture, in a stage where the formation of new bone matrix is still not occurring.…”

Section: Discussionsupporting

confidence: 78%

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Upregulation of Inflammatory Genes and Downregulation of Sclerostin Gene Expression Are Key Elements in the Early Phase of Fragility Fracture Healing

et al. 2011

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BackgroundFracture healing is orchestrated by a specific set of events that culminates in the repair of bone and reachievement of its biomechanical properties. The aim of our work was to study the sequence of gene expression events involved in inflammation and bone remodeling occurring in the early phases of callus formation in osteoporotic patients.Methodology/Principal FindingsFifty-six patients submitted to hip replacement surgery after a low-energy hip fracture were enrolled in this study. The patients were grouped according to the time interval between fracture and surgery: bone collected within 3 days after fracture (n = 13); between the 4th and 7th day (n = 33); and after one week from the fracture (n = 10). Inflammation- and bone metabolism-related genes were assessed at the fracture site. The expression of pro-inflammatory cytokines was increased in the first days after fracture. The genes responsible for bone formation and resorption were upregulated one week after fracture. The increase in RANKL expression occurred just before that, between the 4th–7th days after fracture. Sclerostin expression diminished during the first days after fracture.ConclusionsThe expression of inflammation-related genes, especially IL-6, is highest at the very first days after fracture but from day 4 onwards there is a shift towards bone remodeling genes, suggesting that the inflammatory phase triggers bone healing. We propose that an initial inflammatory stimulus and a decrease in sclerostin-related effects are the key components in fracture healing. In osteoporotic patients, cellular machinery seems to adequately react to the inflammatory stimulus, therefore local promotion of these events might constitute a promising medical intervention to accelerate fracture healing.

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Section: Discussionsupporting

confidence: 80%

Section: Discussionsupporting

confidence: 78%

Upregulation of Inflammatory Genes and Downregulation of Sclerostin Gene Expression Are Key Elements in the Early Phase of Fragility Fracture Healing

et al. 2011

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“…B79-17X-05223-02). 0001-6470/79/030241-03$02.50/0 phase after bone trauma (La1 et al 1976, Lyrits et al 1976. In spite of the fact that serum calcium in man is very well regulated, it may be possible to find a change in the parathyroid hormone (PTH) secretion during the early phase after bone trauma.…”

mentioning

confidence: 99%

Parathyroid Hormone Secretion After Operative Bone Trauma

Hulth

Johnell

1979

Acta Orthopaedica Scandinavica

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“…This gene expression profile had been already observed in other studies [18,21,22] and it is not entirely surprising, since this enzyme is involved in bone matrix production and our study is focused on the early changes related to fracture, in a stage where the formation of new bone matrix is still not occurring.…”

Section: Values Represent Median (Q1-q3)mentioning

confidence: 84%

Upregulation of inflammatory genes and downregulation of sclerostin gene expression are key elements in the early phase of fragility fracture healing

Caetano-Lopes¹,

Lopes²,

Rodrigues³

et al. 2011

Bone

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The Values of Some Plasma Components During the Early Phases of Fracture Healing in Man

Abstract: A study of plasma components during the early phases of fracture healing i n man showed no specific changes except a change of C-reactive protein t o positive and a slight but non-significant increase of the plasma hydroxyproline.

Cited by 5 publications

References 12 publications

Upregulation of Inflammatory Genes and Downregulation of Sclerostin Gene Expression Are Key Elements in the Early Phase of Fragility Fracture Healing

Upregulation of Inflammatory Genes and Downregulation of Sclerostin Gene Expression Are Key Elements in the Early Phase of Fragility Fracture Healing

Parathyroid Hormone Secretion After Operative Bone Trauma

Upregulation of inflammatory genes and downregulation of sclerostin gene expression are key elements in the early phase of fragility fracture healing

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