The values of systemic immune-inflammation index and neutrophil-lymphocyte ratio in predicting testicular germ cell tumors: A retrospective clinical study

Wang, Shuo; Yang, Xiao; Yu, Ziyi; Du, Peng; Cao, Yudong; Ji, Yunpeng; Ma, Jinchao; Yang, Yong

doi:10.3389/fonc.2022.893877

Cited by 7 publications

(9 citation statements)

References 42 publications

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“…Several studies have shown that many types of malignant neoplasms play an important role in the carcinogenic process and survival with respect to systemic inflammation [6][7][8][9][10][11][12][13][14][15][16]24]. Tumor cells themselves release cytokines and chemokines, which are thought to circulate and induce a systemic inflammatory response [25], resulting in changes in neutrophils, lymphocytes, and platelets [26].…”

Section: Discussionmentioning

confidence: 99%

“…Inflammation-related parameters such as NLR, PLR, and SII have been focused on as potential useful markers for the assessment of systemic inflammation, and previous studies have suggested that these biomarkers may be one of the prognostic predictive parameters for PCa [12,26,31]. In a study of 291 patients with pathologically confirmed localized PCa who underwent RP, 114 (39.2%) developed BCR within a median follow-up of 48 months [12]. The incidence of BCR was significantly higher in the high NLR group (50.7%) and the high SII group (48.77%) than in the low NLR and SII groups [12].…”

Section: Discussionmentioning

confidence: 99%

“…The relationships between inflammation-related parameters and tumorigenesis have been widely studied in various tumors [6][7][8][9][10]. In particular, PCa, which is a systemic, multifactorial disease, has been extensively investigated [11][12][13][14][15][16]. Inflammatory cells and mediators in the tumor microenvironment are known to mediate the inflammatory response and further interact with the tumor and peritumoral cells in an autocrine and/or paracrine manner [17].…”

Section: Introductionmentioning

confidence: 99%

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The Negative Impact of Inflammation-Related Parameters in Prostate Cancer after Robot-Assisted Radical Prostatectomy: A Retrospective Multicenter Cohort Study in Japan (the MSUG94 Group)

Murase,

Kawase,

Ebara

et al. 2023

JCM

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Background and Objectives: We aimed to examine the relationship between the inflammation-related parameters, such as the neutrophil-to-lymphocyte ratio (NLR), and the pathological findings and biochemical recurrence (BCR) in patients with prostate cancer (PCa) undergoing robot-assisted radical prostatectomy (RARP). Materials and Methods: A retrospective multicenter cohort study of patients with PCa who underwent RARP at 10 institutes in Japan was conducted. This study enrolled 3195 patients. We focused on patients undergoing RARP who underwent the preoperative measurement of their inflammation-related parameters and who did not receive any neo- or adjuvant therapy. Data on the pre- and postoperative variables for the enrolled patients were obtained. The primary endpoint of this study was the association between BCR and the inflammation-related parameters after RARP. The secondary endpoint was the association between the inflammation-related parameters and the pathological diagnosis of PCa. Results: Data from 2429 patients with PCa who met the study’s eligibility criteria were analyzed. The median follow-up period was 25.1 months. The inflammation-related parameters were divided into two groups, and cutoff values were determined based on the receiver operating characteristics. There were no statistically significant differences in biochemical recurrence-free survival for any of the parameters. In the univariate analysis, the NLR was predictive of pathological T3 and lymphovascular invasion; however, there were no significant differences in the multivariate analysis. Conclusions: The inflammation-related parameters did not significantly affect the incidence of BCR, at least among patients with PCa who underwent RARP.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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The Negative Impact of Inflammation-Related Parameters in Prostate Cancer after Robot-Assisted Radical Prostatectomy: A Retrospective Multicenter Cohort Study in Japan (the MSUG94 Group)

Murase,

Kawase,

Ebara

et al. 2023

JCM

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“…The haematological markers include the neutrophil–lymphocyte ratio (NLR) [ 8 ], the platelet–lymphocyte ratio (PLR) [ 9 ], the modified Glasgow prognostic score (mGPS) [ 10 ], as well as the systemic inflammation index (SII) [ 11 ]. Computational equation for SII is: SII = platelet × neutrophil/lymphocyte [ 12 ]. SII is presented as a combination of NLR and PLR.…”

Section: Introductionmentioning

confidence: 99%

Prognostic and clinicopathological significance of Systemic Immune-Inflammation Index in cancer patients receiving immune checkpoint inhibitors: a meta-analysis

Wang

2023

Annals of Medicine

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Background Among malignant neoplasm patients taking immune checkpoint inhibitors (ICIs), it remains unknown how the systemic immune-inflammation index (SII) affects their clinical prognosis. We therefore performed the present meta-analysis by collecting the most recent data, so that SII’s prognostic value among ICI-receiving carcinoma patients could be fully clarified. Methods For the prognostic significance evaluation of SII in ICI-receiving carcinoma patients, the combined hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated. Results The number of studies enrolled in the present meta-analysis totaled 17, where 1,990 patients were involved. Among the ICI-treated carcinoma patients, a high SII was linked significantly to inferior overall survival (OS) (HR = 2.62, 95% CI = 1.76–3.90), as well as progression-free survival (PFS) (HR = 2.09, 95% CI = 1.48–2.95) ( p both <.001). Contrastively, SII was linked insignificantly to the age (OR = 1.08, 95% CI = 0.39–2.98, p = .881), gender (OR = 1.01, 95% CI = 0.59–1.73, p = .959), lymph node (LN) metastasis (OR = 1.41, 95% CI = 0.92–2.17, p = .117), or metastatic site quantity (OR = 1.49, 95% CI = 0.90–2.46, p = .119). Conclusion There are prominent associations of elevated SII with the poor survival outcomes (both short- and long-terms) among the ICIreceiving carcinoma patients. SII has potential as a reliable and cheap prognostic biomarker in the clinic for carcinoma patients receiving ICIs.

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“…Despite this, new biomarkers with further proper prognostic stratification in germ cell populations are still needed. Programmed death ligand-1 status as well as neutrophil–lymphocyte ratio or systemic inflammatory index were evaluated as prognostic biomarkers in several studies ( 7 , 8 ), with favorable results as independent predictors of outcome in a selected population of germ cell tumors, but their usefulness in practice has not been established. Thus, understanding disease better with more precise identification of patients with an adverse prognosis is crucial to improving patient management, as might be disease monitoring.…”

Section: Introductionmentioning

confidence: 99%

Prognostic role of plasma vitamin D and its association with disease characteristics in germ cell tumours

et al. 2023

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BackgroundTesticular cancer is the most common malignancy among young men. Vitamin D has pluripotent effects on cancer pathogenesis and plays a role in the metastatic cascade. The aim of this study is to analyze plasma vitamin D in association with clinico-pathological findings and prognosis in patients with germ-cell tumors (GCTs).MethodsThis study included 120 newly diagnosed and/or relapsed GCT patients treated from April 2013 to July 2020, for whom plasma was available in the biobank. Blood samples were drawn the 1st chemotherapy cycle as well as before the 2nd cycle. Plasma vitamin D was measured using ELISA and correlated with disease characteristics and the outcome. For survival analysis, the cohort was dichotomized into “low” and “high” based on median vitamin D.ResultsThere was no significant difference in vitamin D plasma levels between healthy donors and GCT patients (p = 0.71). Vitamin D level was not associated with disease characteristics except for brain metastases, where patients with brain metastases had a vitamin D level that was 32% lower compared to patients without brain metastases, p = 0.03. Vitamin D was also associated with response to chemotherapy, with an approximately 32% lower value in patients with an unfavorable response compared to a favorable response, p = 0.02. Moreover, low plasma levels of vitamin D were significantly associated with disease recurrence and inferior progression-free survival (PFS), but not with overall survival (OS) (HR = 3.02, 95% CI 1.36–6.71, p = 0.01 for PFS and HR = 2.06, 95% CI 0.84–5.06, p = 0.14 for OS, respectively).ConclusionOur study suggests the prognostic value of pretreatment vitamin D concentrations in GCT patients. Low plasma vitamin D was associated with an unfavorable response to therapy and disease recurrence. However, it remains to be determined whether the biology of the disease confirms a causative role for low vitamin D and whether its supplementation affects the outcome.

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The values of systemic immune-inflammation index and neutrophil-lymphocyte ratio in predicting testicular germ cell tumors: A retrospective clinical study

Abstract: The values of systemic immuneinflammation index and neutrophillymphocyte ratio in predicting testicular germ cell tumors: A retrospective clinical study.

Cited by 7 publications

References 42 publications

The Negative Impact of Inflammation-Related Parameters in Prostate Cancer after Robot-Assisted Radical Prostatectomy: A Retrospective Multicenter Cohort Study in Japan (the MSUG94 Group)

The Negative Impact of Inflammation-Related Parameters in Prostate Cancer after Robot-Assisted Radical Prostatectomy: A Retrospective Multicenter Cohort Study in Japan (the MSUG94 Group)

Prognostic and clinicopathological significance of Systemic Immune-Inflammation Index in cancer patients receiving immune checkpoint inhibitors: a meta-analysis

Prognostic role of plasma vitamin D and its association with disease characteristics in germ cell tumours

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