The Van Slyke Equation

Siggaard‐Andersen, Ole

doi:10.3109/00365517709098927

Cited by 172 publications

(114 citation statements)

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“…Plasma bicarbonate was calculated according to SiggaardAndersen (32). All plasma flows have been calculated as Q plasma ϭ Q blood ϫ [1 Ϫ (Hct/100)].…”

Section: )) Leg Blood Lactate Release Was Calculated As Lamentioning

confidence: 99%

Human muscle net K⁺ release during exercise is unaffected by elevated anaerobic metabolism, but reduced after prolonged acclimatization to 4,100 m

Nordsborg

Calbet

Sander

et al. 2010

American Journal of Physiology-Regulatory, Integrative and Comp

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Nordsborg NB, Calbet JA, Sander M, van Hall G, Juel C, Saltin B, Lundby C. Human muscle net K ϩ release during exercise is unaffected by elevated anaerobic metabolism, but reduced after prolonged acclimatization to 4,100 m. Am J Physiol Regul Integr Comp Physiol 299: R306 -R313, 2010. First published April 21, 2010; doi:10.1152/ajpregu.00062.2010.-It was investigated whether skeletal muscle K ϩ release is linked to the degree of anaerobic energy production. Six subjects performed an incremental bicycle exercise test in normoxic and hypoxic conditions prior to and after 2 and 8 wk of acclimatization to 4,100 m. The highest workload completed by all subjects in all trials was 260 W. With acute hypoxic exposure prior to acclimatization, venous plasma [K ϩ ] was lower (P Ͻ 0.05) in normoxia (4.9 Ϯ 0.1 mM) than hypoxia (5.2 Ϯ 0.2 mM) at 260 W, but similar at exhaustion, which occurred at 400 Ϯ 9 W and 307 Ϯ 7 W (P Ͻ 0.05), respectively. At the same absolute exercise intensity, leg net K ϩ release was unaffected by hypoxic exposure independent of acclimatization. After 8 wk of acclimatization, no difference existed in venous plasma [K ϩ ] between the normoxic and hypoxic trial, either at submaximal intensities or at exhaustion (360 Ϯ 14 W vs. 313 Ϯ 8 W; P Ͻ 0.05). At the same absolute exercise intensity, leg net K ϩ release was less (P Ͻ 0.001) than prior to acclimatization and reached negative values in both hypoxic and normoxic conditions after acclimatization. Moreover, the reduction in plasma volume during exercise relative to rest was less (P Ͻ 0.01) in normoxic than hypoxic conditions, irrespective of the degree of acclimatization (at 260 W prior to acclimatization: Ϫ4.9 Ϯ 0.8% in normoxia and Ϫ10.0 Ϯ 0.4% in hypoxia). It is concluded that leg net K ϩ release is unrelated to anaerobic energy production and that acclimatization reduces leg net K ϩ release during exercise.

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“…Plasma bicarbonate was calculated according to SiggaardAndersen (32). All plasma flows have been calculated as Q plasma ϭ Q blood ϫ [1 Ϫ (Hct/100)].…”

Section: )) Leg Blood Lactate Release Was Calculated As Lamentioning

confidence: 99%

Human muscle net K⁺ release during exercise is unaffected by elevated anaerobic metabolism, but reduced after prolonged acclimatization to 4,100 m

Nordsborg

Calbet

Sander

et al. 2010

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Möchte man nur die metabolische Komponente der Änderungen von [HCO 3 -] -hervorgerufen durch die Verkleinerung der [SID] -unabhängig vom pCO 2 herausfiltern, benötigt man einen Korrekturfaktor. Der in den 1960er-Jahren entwickelte "base excess" beruht auf einem solchen Korrekturfaktor [6,8]. Der "base excess" stellt den Versuch dar, den in .…”

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Säure-Base-Haushalt aus der Perspektive von P. Stewart

Deetjen

Lichtwarck-Aschoff

2007

Anaesthesist

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We have used the Stewart approach to typical acute and compensated acid-base disorders here. Dedicated software developed by the author is available with this article and will be of help to anyone considering analyzing his or her own patients using the Stewart approach. The Stewart approach shares analytical steps with the more traditional Siggard-Andersen method, and in most cases the two methods arrive at the same therapeutic solutions. The Stewart approach is, however, more than merely a biophysical appendix to the traditional clinical model, since metabolic acid-base disorders in particular are understood within a completely different pathophysiological framework; this results in a fresh and sometimes unexpectedly helpful perspective that highlights the functional relevance of seemingly forgotten components such as the chloride ion or albumin.

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“…In a large series of papers he and co-workers formulate models of acid-base chemistry which for many remain the basis of clinical interpretation. In short, these include the Henderson-Hasselbach equation, the Van Slyke equation for calculating the buffering properties of the blood [40], and a formulation of the oxygen dissociation curve including the Bohr-Haldane effects [41]. Graphical solution of these equations can be viewed as two nomograms [42,43,44], the latter of which provides clinical interpretation of patient state and is included in some commercial blood gas…”

Section: Introductionmentioning

confidence: 99%

The Intelligent Ventilator (INVENT) project: The role of mathematical models in translating physiological knowledge into clinical practice

Rees

2011

Computer Methods and Programs in Biomedicine

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The Van Slyke Equation

Cited by 172 publications

References 3 publications

Human muscle net K⁺ release during exercise is unaffected by elevated anaerobic metabolism, but reduced after prolonged acclimatization to 4,100 m

Human muscle net K⁺ release during exercise is unaffected by elevated anaerobic metabolism, but reduced after prolonged acclimatization to 4,100 m

Säure-Base-Haushalt aus der Perspektive von P. Stewart

The Intelligent Ventilator (INVENT) project: The role of mathematical models in translating physiological knowledge into clinical practice

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The Van Slyke Equation

Cited by 172 publications

References 3 publications

Human muscle net K+ release during exercise is unaffected by elevated anaerobic metabolism, but reduced after prolonged acclimatization to 4,100 m

Human muscle net K+ release during exercise is unaffected by elevated anaerobic metabolism, but reduced after prolonged acclimatization to 4,100 m

Säure-Base-Haushalt aus der Perspektive von P. Stewart

The Intelligent Ventilator (INVENT) project: The role of mathematical models in translating physiological knowledge into clinical practice

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Human muscle net K⁺ release during exercise is unaffected by elevated anaerobic metabolism, but reduced after prolonged acclimatization to 4,100 m

Human muscle net K⁺ release during exercise is unaffected by elevated anaerobic metabolism, but reduced after prolonged acclimatization to 4,100 m