The `vanishing embryo' phenomenon in an oocyte donation programme

Rodríguez-González, Manuel; Serra, Vicente; García-Velasco, Juan A.; Pellicer, António; Remohı́, José

doi:10.1093/humrep/17.3.798

Cited by 26 publications

(13 citation statements)

References 29 publications

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“…Rodriguez-Gonzalez et al found that the Fig. 1 Retrieved oocytes a from a young infertility patient b from a young egg donor, and c embryo quality on day-2 post retrieval in a young patient incidence of vanishing embryo phenomenon in oocyte donation pregnancies was significantly higher than in IVF or ICSI pregnancies [4]. They were uncertain about the explanation for these differences, although they did observe a higher multiple pregnancy rate in oocyte donation (68.7%).…”

Section: Discussionmentioning

confidence: 98%

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The effect of age on in vitro fertilization outcome: is too young possible?

Nazemian

Esfandiari

Javed

et al. 2010

J Assist Reprod Genet

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Purpose The negative correlation between fecundity and age in women has been extensively documented although data on reproductive performance in very young women is sparse. The objective of this study was to determine whether age ≤25 years has an impact on reproductive outcome in women undergoing IVF-ET. Methods IVF outcome in 85 infertility patients aged 19-25 years was compared to that in 69 infertility patients aged 30-35 years. Primary outcomes included fertilization rates and embryo quality. Secondary outcomes were clinical pregnancy and miscarriage rates. Results The young patients (≤25 years) demonstrated a lower fertilization rate, and reduced number of top quality embryos. Although clinical pregnancy, and implantation rates were similar to their older counterparts (30-35 years), the young women had a significantly higher miscarriage rate. Conclusion Our results demonstrating poorer reproductive performance in very young patients were surprising and need further investigation.

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Section: Discussionmentioning

confidence: 98%

“…Moreover, the frequency of vanishing embryos in patients with multiple pregnancies from oocyte donation is relatively high. The vanishing embryo phenomenon is defined as the early resorption, in the first trimester, of one or more embryos in a multiple gestation, after confirmation by transvaginal ultrasound [4].…”

Section: Introductionmentioning

confidence: 99%

The effect of age on in vitro fertilization outcome: is too young possible?

Nazemian

Esfandiari

Javed

et al. 2010

J Assist Reprod Genet

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“…There is no clear consensus within the literature regarding obstetrics and perinatal outcomes of those pregnancies. VTS was found to be associated with an increased risk for congenital anomalies [21], vaginal bleeding and PROM as compared with other types of gestation [22]. Our results showed that there is no increased risk of fetal malformation in patients with VTS.…”

Section: Discussionmentioning

confidence: 43%

Maternal and perinatal outcomes of dichorionic diamniotic twin pregnancies diagnosed with vanishing twin syndrome: a retrospective analysis from a single clinical center

et al. 2018

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Objectives: Multiple pregnancies are known to be associated with adverse maternal and perinatal complications. However, data regarding the outcomes of spontaneously reduced twin pregnancies are limited. In the current study we aimed to evaluate the consequences of the vanishing twin syndrome (VTS) in dichorionic diamniotic twin pregnancies for both mother and baby in our perinatal center. Material and methods:A total of 711 pregnancies were included into the study. 51 cases of vanishing twin syndrome constituted Group 1, 235 cases of normal twins constituted Group 2, and 425 singleton pregnancies formed Group 3. The pregnancies that had multifetal reduction and monochorionic twinning were excluded from both study group and twin control group. The collected data were as follows: age, gravidity, parity, gestational week at birth, delivery route, birth weight, obstetric complications, and maternal and perinatal outcomes.

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“…Loss of one fetus in a twin conception may occur as early as 6 weeks and may be asymptomatic. It has been reported that, in 80% of cases, the event occurs before 8 weeks of gestation and the remaining between the 9th and 11th week (Rodríguez-González et al, 2002). In spontaneous pregnancies scanning is rarely done so early in gestation.…”

Section: Discussionmentioning

confidence: 99%

Vanishing Twin: A Possible Cause of Cerebral Impairment

Anand¹,

Platt

Pharoah

2007

Twin Res Hum Genet

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Fetal death in a twin conception during second and third trimester is associated with increased risk of cerebral injury in the surviving twin. The aim of this study is to test the hypothesis that even early fetal losses as a ‘vanishing’ twin may be associated with an increased risk of cerebral impairment in the surviving twin. The study population comprised 362 pregnant women attending Liverpool Women's Hospital recruited between 1999 and 2001. Women were classified according to the first ultrasound scan into 3 groups: vanishing twin, twin and singleton. The vanishing twin group was further subdivided into ‘definite’ and ‘probable’. Children from these pregnancies were assessed at 1 year of age for their development and neurological function using the Griffiths Mental and Developmental Scales and Optimality score. Children from 229 pregnancies (63.2%) attended the assessment. Information on children from a further 21 (5.8%) pregnancies was obtained through a review of hospital records. Cerebral impairment was found in 2 children from the vanishing twin group, 2 from the twin group and none from the singleton group. When cases with definite vanishing twin are considered there is a significant difference between the vanishing twin and singleton group (relative risk 6.1; 95% confidence interval 1.5–8.3; p = .03). An additional study with an increased sample size would enable a more robust conclusion.

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The `vanishing embryo' phenomenon in an oocyte donation programme

Abstract: The high incidence of VE in pregnancies achieved by oocyte donation should be considered when counselling patients with high order multiple gestations.

Cited by 26 publications

References 29 publications

The effect of age on in vitro fertilization outcome: is too young possible?

The effect of age on in vitro fertilization outcome: is too young possible?

Maternal and perinatal outcomes of dichorionic diamniotic twin pregnancies diagnosed with vanishing twin syndrome: a retrospective analysis from a single clinical center

Vanishing Twin: A Possible Cause of Cerebral Impairment

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