The Variability of Growth Hormone Gene Associated with Ultrasound Imaging of Longissimus dorsi Muscle and Perirenal Fat in Rabbits

Amalianingsih, Tya I; Brahmantiyo, Bram; Jakaria, Md.

doi:10.5398/medpet.2014.37.1.1

Cited by 8 publications

(11 citation statements)

References 21 publications

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“…On the contrary, the distribution of allele frequencies in outbred NZW rabbits was 0.613 (allele С) and 0.387 (allele T) and the homozygous CC genotype was therefore more frequently encountered than the homozygous TT genotype (0.300 vs. 0.075). Тhe observed preponderance of allele C compared to allele T was also reported by Amalianingsih et al (2014) in New Zealand White and California rabbit breeds (0.625 vs. 0.375). Our results for the NZW breed disagreed with data reported by Fontanesi et al (2012) for higher prevalence of allele T (frequency 0.594) over allele C (frequency 0.406) in Checkered Giant rabbits.…”

Section: Resultssupporting

confidence: 67%

“…GH gene mutations are described in several species, but so far, only few studies have researched its variability in rabbits. Polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) analyses of single nucleotide polymorphisms (SNP) of the rabbit GH gene were recently reported by Fontanesi et al (2012), Amalianingsih et al (2014) and Hussein et al (2015). The GH SNP and its association with body weight and growth performance traits in different domestic rabbit breeds and their strains were successfully determined (Qiao, 2010, Fontanesi et al, 2012.…”

Section: W O R L D R a B B I T S C I E N C Ementioning

confidence: 99%

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Single nucleotide polymorphism of the growth hormone (GH) encoding gene in inbred and outbred domestic rabbits

et al. 2018

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Taking into consideration that the growth hormone (GH) gene in rabbits is a candidate for meat production, understanding the genetic diversity and variation in this locus is of particular relevance. The present study comprised 86 rabbits (Oryctolagus cuniculus) divided into 3 groups: New Zealand White (NZW) outbred rabbits; first-generation inbred rabbits (F 1 ) and second-generation inbred rabbits (F 2 ). They were analysed by polymerase chain reaction-based restriction fragment length polymorphism method. A 231 bp fragment of the polymorphic site of the GH gene was digested with Bsh1236 restriction enzyme. Single nucleotide polymorphisms for the studied GH locus corresponding to 3 genotypes were detected in the studied rabbit populations: CC, CT and TT. In the synthetic inbred F 1 and F 2 populations, the frequency of the heterozygous genotype CT was 0.696 and 0.609, respectively, while for the homozygous CC genotype the frequency was lower (0.043 and 0.000), and respective values for the homozygous TT genotype were 0.261 and 0.391. This presumed a preponderance of the T allele (0.609 and 0.696) over the C allele (0.391 and 0.304) in these groups. In outbred rabbits, the allele frequencies were 0.613 (allele C) and 0.387 (allele Т); consequently, the frequency of the homozygous CC genotype was higher than that of the homozygous TT genotype (0.300 vs. 0.075). Observed heterozygosity for the GH gene was higher than expected, and the result was therefore a negative inbreeding coefficient (Fis=-0.317 for outbred NZW rabbits; -0.460 for inbred F 1 and -0.438 for inbred F 2 ), indicating a sufficient number of heterozygous forms in all studied groups of rabbits. The application of narrow inbreeding by breeding full sibs in the synthetic population did not cause a rapid increase in homozygosity.

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Section: Resultssupporting

confidence: 67%

Section: W O R L D R a B B I T S C I E N C Ementioning

confidence: 99%

Single nucleotide polymorphism of the growth hormone (GH) encoding gene in inbred and outbred domestic rabbits

et al. 2018

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“…The genetic polymorphisms in loci encoding growth hormone and myostatin have so far been described in several livestock species, but only few studies have investigated their variability in the rabbit genome. Based [6][7][8][9][10]3] Also, the GH and MSTN the gene polymorphisms and their association with different performance traits were successfully determined in Oryctolaguscuniculus [11][12][13][14][15]. The present study was focused on identification of the polymorphisms at GH and MSTN genes in rabbits from the New Zealand White breed, reared in Bulgaria and on establishment of the genetic structure of their populations, by means of PCR-RFLP analysis.…”

Section: Introductionmentioning

confidence: 99%

Rabbit Growth Hormone and Myostatin Gene Polymorphisms

Hristova¹

2017

OAJAR

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“…Currently, the existence of selection and crossbreeding performed in rabbits with potential for meat in Indonesia are usually seen from the aspect of phenotype includes performance and productivity, while the genetic aspects (gene) is still limited. Identification of gene in Indonesian rabbit has investigated by Amalianingsih et al (2014). Selection by phenotypic aspect must be done in a longer time with economically expensive.…”

Section: Introductionmentioning

confidence: 99%