The Variations and Course of Lichen Planus

Altman, Jules; Perry, Harold O.

doi:10.1001/archderm.1961.01580140005001

Cited by 214 publications

(108 citation statements)

References 14 publications

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“…(1,7)  A familial incidence of 15% was reported in our study in contrast to 1-2%observed by samman et al & altmann et al (3,8)  Most common site of involvement observed in various studies, (1,6,7) were lower limbs followed by trunk which were in concurrence with our observation  Nail involvement is rare in children and an incidence of 1-10% was observed in adults.…”

Section: Discussionsupporting

confidence: 88%

A CLINICAL & EPEDEMIOLOGICAL PROFILE OF LICHEN PLANUS AMONG CHILDREN

S¹,

P²,

Krishnarao³

et al. 2015

jemds

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Lichen planus (LP) is a common papulosquamous disorder of auto-immune Etiology characterised by pruritic, polygonal, purple, papules which was first described by Erasmus Wilson in 1869. LP affects all age groups and both sexes equally. Most cases have been reported in adult population but a few case series were present among children. This prompted us to carry-out the present study. MATERIALS & METHODS:The present study was carried out for a period of 1year from April 2014 to April 2015 which includes a sample size of 20 patients (n=20), attended to the dermatology OPD, Andhra Medical College, Visakhapatnam. Present study was done in children of less than 12 years of age including both sexes. Routine investigations such as hemogram, liver function test, and renal function test & serological test have been done, detailed immunisation history has been recorded, detailed medical & family history as well as drug history has been recorded. RESULTS: in our study the most common age group was in between 5 and 10 years. Among sex distribution male children were predominantly affected. Regarding the distribution of lesions lower limbs followed by trunk were the common sites to be effected, the most common morphological variants observed in our study were classical type followed by hypertrophic variant. CONCLUSION: our study concluded that the common age group was between 5 and 10 years and the most common presentation was classical type effecting the male children predominantly.

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Section: Discussionsupporting

confidence: 88%

A CLINICAL & EPEDEMIOLOGICAL PROFILE OF LICHEN PLANUS AMONG CHILDREN

S¹,

P²,

Krishnarao³

et al. 2015

jemds

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“…Bulla formation in LP is unusual (except in LP pemphigoides) and may affect about 3 5% of patients (Altman and Perry, 1961 Lichen planopilaris, more common in women, shows a spinous pattern due to follicular involvement of hairbearing areas (Fig. II).…”

Section: Vesiculobullous Lpmentioning

confidence: 99%

“…Most studies have not objectively examined the stress levels. In 1961, Altman and Perry reported that, of 197 patients with LP, "10% were aware of a precipitating stressful incident at the onset of their LP" (Altman and Perry, 1961). The concomitance of LP, especially in its oral form, with situations of emotional stress or anxiety thus entered the literature.…”

Section: (8) Stressmentioning

confidence: 99%

Update On Oral Lichen Planus: Etiopathogenesis and Management

Scully

Beyli²,

Ferreiro

et al. 1998

Critical Reviews in Oral Biology & Medicine

476

461

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Lichen planus (LP) is a relatively common disorder of the stratified squamous epithelia, which is, in many ways, an enigma. This paper is the consensus outcome of a workshop held in Switzerland in 1995, involving a selection of clinicians and scientists with an interest in the condition and its management. The oral (OLP) eruptions usually have a distinct clinical morphology and characteristic distribution, but OLP may also present a confusing array of patterns and forms, and other disorders may clinically simulate OLP. Lesions may affect other mucosae and/or skin. Lichen planus is probably of multifactorial origin, sometimes induced by drugs or dental materials, often idiopathic, and with an immunopathogenesis involving T-cells in particular. The etiopathogenesis appears to be complex, with interactions between and among genetic, environmental, and lifestyle factors, but much has now been clarified about the mechanisms involved, and interesting new associations, such as with liver disease, have emerged. The management of lichen planus is still not totally satisfactory, and there is as yet no definitive treatment, but there have been advances in the control of the condition. There is no curative treatment available; immunomodulation, however, can control the condition. Based on the observed increased risk of malignant development, OLP patients should be offered regular follow-up examination from two to four times annually and asked to report any changes in their lesions and/or symptoms. Follow-up may be particularly important in patients with atrophic/ulcerative/erosive affections of the tongue, the gingiva, or the buccal mucosa. Much more research is required into the genetic and environmental aspects of lichen planus, into the premalignant potential, and into the possible associations with chronic liver, and other, disorders. More clinical studies are required into the possible efficacy of immunomodulatory drugs such as pentoxifylline and thalidomide.

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“…5,11,12 Altman, Perry, 13 Scott and Scott 14 reported nail changes occurring in 1 -16% of the patients, whereas Scott and Scott 14 reported longitudinal ridging, grooving, splitting, striations, anonychia, subungual hyperkeratosis and thinning. Kacchawa et al, 3 Abdel-Hamid and Abdel-Aziz 7 reported nail changes in 6.4% and 7% of their patients of LP respectively with thinning, pterygium and complete destruction as the findings.…”

Section: Discussionmentioning

confidence: 99%