The Vascular Actions of Aqueous Extract ofLippia multiflora

Abstract

Intravenously administered aqueous leaf extract (6.3 to 12.5 mg/kg) in anaesthetised cats and (3.2 to 6.3 mg/kg) in anaesthetised rats, produced a significant fall (P < 0.05, n 10) in the mean, systolic and diastolic blood pressure by as much as 75 mm Hg in cats and 35 10.00mm Hg in rats. On the raised arterial perfusion pressure of the rabbit central ear artery preparation, the extract (12.5-50 sg) produced a transient rise in perfusion pressure, which was followed by a more significant and prolonged fall in the perfusion pressure. Phentolamine (1.0 sg/ml) antagonised the transient rise and propranolol (1.0 tg/ml abolished the fall in perfusion pressure. The results suggested: that vasodilatation, resulting from a combination of alpha-adrenoceptor blockade and beta-adrenoceptor stimulant action of the extract, aided by skeletal muscle relaxation might be responsible for the blood pressure lowering effect of the extract.

Acaricidal efficacy against cattle ticks and acute oral toxicity of Lippia javanica (Burm F.) Spreng

“…In that experiment, the tranquilizer and analgesic phase was preceded by a precocious ataxic phase and the quality of the symptoms and signs observed were dose dependant unlike in the present study. In another study, aqueous leaf extracts of the same plant administered intraperitonially produced a profound muscle relaxing action, considered to be primarily responsible for the calming effect which bordered on tranquilization, at doses of 0.25 to 1.0 g/kg and 0.5 to 1.0 mg/ml in amphetaminemedicated mice and unmedicated rats, respectively (Noamesi et al 1985b). The congestion and haemorrhage observed at post-mortem of some of the mice are consistent with the peripheral vasodilation which occurs with high doses of caffeine (Lewis 1965).…”

Variabilité de la composition chimique de l’huile essentielle des feuilles de <i>Lippia multiflora</i> cultivées en Côte d’Ivoire

“…Ainsi, il est octroyé à Lippia multiflora Mold., des propriétés sédatives (Etou-Ossibi et al, 2005), anti infectieuses buccales (Menut et al, 1993), antitussives (Pascual et al, 2001) dans l'inflammation bronchique, antispasmodiques dans les troubles gastrointestinaux, hypotensives, et comme complément thérapeutique dans la fièvre de malaria (Valentin et al, 1995.). Également des propriétés bactériostatiques lui ont été attribuées (Noamesi, 1977(Noamesi, -1985, (Pham et al, 1988), (Pélissier et al, 1998). Diverses études menées sur la composition chimique de l'huile essentielle dans la sous-région ont révélées la présence de plusieurs chémotypes dont -L. multiflora Mold.…”

Chemical screening and effects of aqueous extract of Lippia multiflora on isolated toad’s heart

“…Cette diminution du débit cardiaque pourrait participer à l'effet antihypertenseur du L. multiflora signalé dans la littérature [16,23]. L. multiflora s'oppose à l'effet inotrope positif du CaCl 2 alors qu'il est sans effet sur l'effet chronotrope négatif de cette substance.…”