2004
DOI: 10.1016/s0002-9440(10)63711-x
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The Vascular Endothelial Growth Factor (VEGF) Receptor Flt-1 (VEGFR-1) Modulates Flk-1 (VEGFR-2) Signaling During Blood Vessel Formation

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Cited by 172 publications
(144 citation statements)
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“…1B). 21,22 Our own unpublished data further show strong upregulation of neuropilin-1 (Nrp1) following inhibition of Notch signalling. As Nrp1 is considered a positive modulator of VEGFR2 signalling, 23 regulation of net VEGFR2 activity, not levels, could be achieved through Notch mediated fine tuning of VEGF co-receptors VEGFR1 and Nrp1.…”
Section: Introductionmentioning
confidence: 88%
“…1B). 21,22 Our own unpublished data further show strong upregulation of neuropilin-1 (Nrp1) following inhibition of Notch signalling. As Nrp1 is considered a positive modulator of VEGFR2 signalling, 23 regulation of net VEGFR2 activity, not levels, could be achieved through Notch mediated fine tuning of VEGF co-receptors VEGFR1 and Nrp1.…”
Section: Introductionmentioning
confidence: 88%
“…VEGF is a critical inducer of proliferation, migration, sprouting, and tube formation in tissues during angiogenesis (Tammela et al, 2005). Its binding sites VEGFR-1/Flt-1 and VEGFR-2/Flk-1 work in a competitive way to regulate the VEGF signal in response to variations in physiological conditions (Ferrara et al, 2003;Kearney et al, 2004;Roberts et al, 2004;Ferrara, 2005;Marti, 2005;Nanka et al, 2006).…”
Section: Introductionmentioning
confidence: 99%
“…Flt-1 negatively modulates vascular growth by controlling the rate of endothelial cell division by dampening signaling through flk-1. 12,15,16,22) VEGF signaling through flk-1 produces several cellular responses, including a strong mitogenic signal and a survival signal for endothelial cells and their precursors. 2,7) VEGF is thought to act through a paracrine pathway via receptors flt-1 and flk-1.…”
Section: Introductionmentioning
confidence: 99%