The vascular formations in glioblastoma

Storring, F. K.; Duguid, J. B.

doi:10.1002/path.1700680128

Cited by 19 publications

(7 citation statements)

References 4 publications

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“…Certainly the amount of FVIIIR:Ag found in the endothelial cells and subendothelial space of malignant brain tumor vessels is abnormal. In the blood vessels in the growing margin of the glioblastoma, thrombus formation with endothelial proliferation is sometimes seen (17,30). It may be that these phenomena are due to local hyper-coagulation in malignant tumor tissues.…”

Section: Discussionmentioning

confidence: 99%

Immunocytochemical localization of factor VIII-related antigen in tumors of the human central nervous system

Miyagami¹,

Smith²,

McKeever³

et al. 1987

J Neuro-Oncol

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Using both immunohisto- and immunocytochemical techniques with periodate-lysine-paraformaldehyde (PLP) fixation, we have studied the distribution of Factor VIII-related antigen (FVIIIR:Ag) in 12 cases of tumors of the human central nervous system (CNS) and one sample of non-tumor brain tissue. FVIIIR:Ag was found both extracellularly and intracellularly. It was localized in the vascular lumen, between endothelial cells, and in the endothelial cell basement membrane. In the endothelial cell cytoplasm, FVIIIR:Ag was found in the endoplasmic reticulum, perinuclear space, and in intracytoplasmic vacuoles and vesicles. Characteristic of malignant tumors (six out of seven) was a strongly-positive dilated endoplasmic reticulum. This may reflect increased FVIIIR:Ag synthesis in the endothelial cells of malignant tumors. Only one of five benign tumors showed such staining. Six of 12 tumors and the non-tumor brain showed perinuclear FVIIIR:Ag. Both ad- and abluminal vesicles in the tumor endothelial cells contained FVIIIR:Ag suggesting that endocytosis, transcellular transport, and/or endocytosis, as well as FVIIIR:Ag synthesis occurs. The non-tumor brain showed normal capillary structure and very little FVIIIR:Ag immunoreactivity. The relationship of these FVIIIR:Ag abnormalities to the hypercoagulable state seen in some malignant brain tumor patients remains to be clarified.

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Section: Discussionmentioning

confidence: 99%

Immunocytochemical localization of factor VIII-related antigen in tumors of the human central nervous system

Miyagami¹,

Smith²,

McKeever³

et al. 1987

J Neuro-Oncol

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“…The blood vessels of an astrocytoma tend to be abnormal, often thickened, fibrotic, hyalinized, and sometimes necrotic and thrombosed. 17, 39 We are concerned particularly with the hypertrophy and hyperplasia of endothelial cells and possibly other mural cell elements, which tend to be more severe the greater the degree of anaplasia of the astrocytoma. This hyperplastic reaction is common in the brain in response to almost any injurious process, and in fact a slight degree of such endothelial hyperplasia may be seen in low-grade gliomas; the response to the presence of malignant tumors, however, may be of far greater severity than that induced by these other processes.…”

Section: Discussionmentioning

confidence: 99%

Clinical and pathological study of 24 cases of gliosarcoma

Morantz¹,

Feigin²,

Ransohoff³

1976

Journal of Neurosurgery

196

110

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The authors review the clinical and pathological features of 24 patients with gliosarcoma. The study revealed the following findings. Gliosarcoma occurs more frequently than is indicated in the literature, and in our series was present in 8% of all cases of glioblastoma multiforme. The presenting features are not significantly different from those of glioblastoma multiforme. The lesion often presents itself at surgery as a firm, well circumscribed mass within the temporal lobe, and at surgery it is commonly mistaken for a meningioma. There is an increased likelihood of metastasis compared to that of glioblastoma. The prognosis is no worse than that of glioblastoma, in spite of the addition of sarcomatous elements.

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“…Neuropathologists, however, have only rarely commented on this finding. Some early studies suggested that thrombosis might lead directly to microvascular hyperplasia through active vascular reorganization and recanalization (33). Others noted that thrombosis is typically located centrally in GBM, near coagulative necrosis, and is geographically separate from microvascular hyperplasia, which is more peripheral (28,31).…”

Section: Discussionmentioning

confidence: 99%

RESEARCH ARTICLE: Intravascular Thrombosis in Central Nervous System Malignancies: A Potential Role in Astrocytoma Progression to Glioblastoma

Tehrani

Friedman²,

Olson

et al. 2008

Brain Pathology

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The presence of necrosis within a diffuse glioma is a powerful predictor of poor prognosis, yet little is known of its origins. Intravascular thrombosis is a frequent finding in glioblastoma [GBM; World Health Organization (WHO) grade IV] specimens and could potentially be involved in astrocytoma progression to GBM or represent a surrogate marker of GBM histology. We investigated whether intravascular thrombosis was more frequent or prominent in GBM than other central nervous system (CNS) malignancies and considered its prognostic significance in anaplastic astrocytoma (AA; WHO grade III), which lacks necrosis. Histologic sections were examined for thrombosis, necrosis and microvascular hyperplasia from each of 297 CNS tumors, including 103 GBMs, 46 AAs, 20 diffuse astrocytoma (DAs; WHO grade II), eight anaplastic oligodendrogliomas (AOs; WHO grade III), 20 oligodendrogliomas (ODs; WHO grade II), 49 metastatic carcinomas (METs), 31 primary central nervous system lymphomas (PCNSLs) and 20 medulloblastomas (MBs). Among newly diagnosed tumors, thrombosis was present in 92% of GBM resections, significantly greater than other types of CNS malignancies. Of tumors with thrombosis, GBMs had a higher frequency of affected vessels than AAs, DAs, AOs, ODs and MBs, but had a frequency similar to METs and PCNSLs. The sensitivity of thrombosis for the diagnosis of GBM in this set of tumors was 92% and the specificity was 91%. Intravascular thrombosis was uncommon in AAs and was only noted in stereotactic biopsies. This subset of patients had shorter survivals than those AAs without thrombosis. Thus, intravascular thrombosis is more frequent in GBM than other CNS malignancies. When present in AAs, it appears to indicate aggressive clinical behavior.

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The vascular formations in glioblastoma

Cited by 19 publications

References 4 publications

Immunocytochemical localization of factor VIII-related antigen in tumors of the human central nervous system

Immunocytochemical localization of factor VIII-related antigen in tumors of the human central nervous system

Clinical and pathological study of 24 cases of gliosarcoma

RESEARCH ARTICLE: Intravascular Thrombosis in Central Nervous System Malignancies: A Potential Role in Astrocytoma Progression to Glioblastoma

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