The vascular protection of ditazole and its effect on arachidonic acid metabolism

New 2-(4-(4-bromophenylsulfonyl)phenyl)-4-arylidene-oxazol-5(4H)-ones: analgesic activity and histopathological assessment

“…Also, ditazole, a drug containing an oxazole nucleus, is a non-steroidal anti-inflammatory agent, that is used as platelets aggregation inhibitor [3,16,17].…”

Synthesis, characterization and Cytotoxicity Evaluation of New Heterocyclic Compounds with Oxazole Ring Containing 4-(Phenylsulfonyl)phenyl Moiety

“…In this regard, the 1,3-oxazole ring is found in the structure of various biologically active natural products, such as Martefragin A (a potent inhibitor of lipid peroxidation) [1], Diazonamide A (an anticancer agent that inhibits tubulin polymerization) [2], Virginiamycin M 2, Madumycin II, Griseoviridin (representative examples of the group A streptogramin antibiotics) [3], Calyculin A (a potent, selective serine-threonine phosphatase inhibitor) [4], Hennoxazole A (active against herpex simplex virus type 1 and with peripheral analgesic activity) [1], Muscoride A (an antibacterial agent) [5], Ulapualide A (with antifungal effect) [1], Texaline (an antimycobacterial alkaloid) [6]. Also, members of 1,3-oxazole class are active substances in several modern pharmaceuticals, including Oxaprozin (a non-opioid analgesic, antipyretic, and non-steroidal antiinflammator y drug) [7], Aleglitazar, Farglitazar, Muraglitazar (dual PPARα/γ agonists from glitazar class used in treatment of type 2 diabetes) [8], Ditazole (an inhibitor of platelet aggregation) [9], Mubritinib (a tyrosine kinase inhibitor) [10], Sulfamoxole (a chemotherapeutic agent from the sulfonamides group with antibacterial activity) [11], Azumolene (which exhibit skeletal muscle relaxant action) [12].…”