The vascular role of CGRP: a systematic review of human studies

Al‐Karagholi, Mohammad Al‐Mahdi; Kalatharan, Veberka; Fagerberg, Peter Schunck; Amin, Faisal Mohammad

doi:10.3389/fneur.2023.1204734

Cited by 6 publications

(2 citation statements)

References 63 publications

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“…Glibenclamide did not affect the baseline diameter of intra- and extracerebral arteries ( 6 ). In contrast to preclinical studies, glibenclamide failed to attenuate the vasodilation induced by levcromakalim ( 6 ) or by other potent endogenous vasodilators including the calcitonin gene-related peptide (CGRP) ( 67 , 71 ) and the pituitary adenylate cyclase-activating polypeptide (PACAP-38) ( 64 ).…”

Section: Resultsmentioning

confidence: 88%

KATP channels in cerebral hemodynamics: a systematic review of preclinical and clinical studies

Daoud,

Kokoti,

Al-Karagholi

2024

Front. Neurol.

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Cumulative evidence suggests that ATP-sensitive potassium (KATP) channels act as a key regulator of cerebral blood flow (CBF). This implication seems to be complicated, since KATP channels are expressed in several vascular-related structures such as smooth muscle cells, endothelial cells and pericytes. In this systematic review, we searched PubMed and EMBASE for preclinical and clinical studies addressing the involvement of KATP channels in CBF regulation. A total of 216 studies were screened by title and abstract. Of these, 45 preclinical and 6 clinical studies were included. Preclinical data showed that KATP channel openers (KCOs) caused dilation of several cerebral arteries including pial arteries, the middle cerebral artery and basilar artery, and KATP channel inhibitor (KCI) glibenclamide, reversed the dilation. Glibenclamide affected neither the baseline CBF nor the baseline vascular tone. Endothelium removal from cerebral arterioles resulted in an impaired response to KCO/KCI. Clinical studies showed that KCOs dilated cerebral arteries and increased CBF, however, glibenclamide failed to attenuate these vascular changes. Endothelial KATP channels played a major role in CBF regulation. More studies investigating the role of KATP channels in CBF-related structures are needed to further elucidate their actual role in cerebral hemodynamics in humans.Systematic review registration: Prospero: CRD42023339278 (preclinical data) and CRD42022339152 (clinical data).

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Section: Resultsmentioning

confidence: 88%

KATP channels in cerebral hemodynamics: a systematic review of preclinical and clinical studies

Daoud,

Kokoti,

Al-Karagholi

2024

Front. Neurol.

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“…These are administered through subcutaneous injection and target CGRP, blocking its advancement. However, these drugs should not be taken by cardiopathic and hypertensive patients [39]. Pain relievers, such as nonsteroidal anti-inflammatory drugs (NSAIDs) or acetaminophen, are used to treat mild to moderate migraines and can be taken alone or in combination with triptans.…”

Section: Therapies Based On the Different Forms Of Migrainementioning

confidence: 99%

CGRP Antagonism and Ketogenic Diet in the Treatment of Migraine

Finelli,

Catalano,

De Lisa

et al. 2024

Medicina

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The study of migraine is based on the complexity of the pathology, both at the pathophysiological and epidemiological levels. Although it affects more than a billion people worldwide, it is often underestimated and underreported by patients. Migraine must not be confused with a simple headache; it is a serious and disabling disease that causes considerable limitations in the daily life of afflicted people, including social, work, and emotional effects. Therefore, it causes a daily state of suffering and discomfort. It is important to point out that this pathology not only has a decisive impact on the quality of life of those who suffer from it but also on their families and, more generally, on society as a whole. The clinical picture of migraine is complex, with debilitating unilateral or bilateral head pain, and is often associated with characteristic symptoms such as nausea, vomiting, photophobia, and phonophobia. Hormonal, environmental, psychological, dietary, or other factors can trigger it. The present review focuses on the analysis of the physiopathological and pharmacological aspects of migraine, up to the correct dietary approach, with specific nutritional interventions aimed at modulating the symptoms. Based on the symptoms that the patient experiences, targeted and specific therapy is chosen to reduce the frequency and severity of migraine attacks. Specifically, the role of calcitonin gene-related peptide (CGRP) in the pathogenesis of migraine is analyzed, along with the drugs that effectively target the corresponding receptor. Particularly, CGRP receptor antagonists (gepants) are very effective drugs in the treatment of migraine, given their high diffusion in the brain. Moreover, following a ketogenic diet for only one or two months has been demonstrated to reduce migraine attacks. In this review, we highlight the diverse facets of migraine, from its physiopathological and pharmacological aspects to prevention and therapy.

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