The vasculopathic reaction pattern

Weedon, David

doi:10.1016/b978-0-7020-3485-5.00009-7

Cited by 29 publications

(54 citation statements)

References 2,070 publications

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“…Characteristic histological features of SS include dense infiltration of neutrophils in the upper and mid dermis (sparing the epidermis), oedema in the superficial dermis, leukocytoclasia and endothelial swelling. Vasculitis is not a feature 9. A leukocytosis (neutrophilia) on serology is consistent with SS.…”

Section: Discussionmentioning

confidence: 94%

Sweet's syndrome in a patient with chronic lymphocytic leukaemia

Smith¹,

Williams

2017

BMJ Case Reports

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Bullous Sweet's syndrome is a rare variant of the inflammatory neutrophilic dermatosis characterised by painful bullous skin lesions, fever, leukocytosis and a neutrophilic infiltrate of the dermis. The condition may be classified according to aetiology into classical (idiopathic), malignancy-associated and drug-induced. Neutrophilic infiltration occurs in response to a systemic insult. A punch biopsy for histology and culture is necessary due to its close resemblance to infection. Characteristic histology features a dense infiltration of neutrophils in the upper and mid dermis, oedema in the superficial dermis and endothelial swelling. Treatment with systemic glucocorticosteroids typically results in a dramatic clinical response. This case report illustrates a rare case of bullous Sweet syndrome associated with chronic lymphocytic leukaemia in a 53-year-old man.

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Section: Discussionmentioning

confidence: 94%

Sweet's syndrome in a patient with chronic lymphocytic leukaemia

Smith¹,

Williams

2017

BMJ Case Reports

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“…Although there may be some overlappings between EPC and APEX, EPC differs from APEX in its characteristics of male preponderance, average age at onset of 45 years, high relapse rate and unique annular configuration. Lichen striatus, cutaneous lupus erythematosus [11] and perniosis [13] often demonstrate perieccrine mononuclear cell infiltration, although the clinical manifestations differ from EPC. Interestingly, Fowler et al [14] reported that 10 of 26 subjects allergic to hexavalent chromium demonstrated perieccrine inflammation after immersion of the skin in a potassium chromate bath.…”

Section: Discussionmentioning

confidence: 99%

“…Most of the reported EPC cases were free of systemic diseases, though our 2 cases were accompanied by polymyositis and interstitial pneumonia or advanced gastric cancer. A variety of agents have been implicated in the etiology of EAC, including infection by bacteria, rickettsia or [11] . On the other hand, because of the histological characteristics of EPC, i.e.…”

Section: Discussionmentioning

confidence: 99%

A New Type of Annular Erythema with Perieccrine Inflammation: Erythema Papulatum Centrifugum

Ohmori¹,

Kikuchi²,

Yamasaki³

et al. 2013

Dermatology

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Erythema papulatum centrifugum (EPC) was first described in 1962 by Watanabe [Jpn J Dermatol 1962;72:573] as eczematous lesions extending centrifugally. To date, more than 150 cases have been reported, but only in the Japanese literature. A review of the Japanese literature including our 5 new cases reveals that EPC occurs in middle-aged persons, predominantly in males, as a single lesion on the trunk that is self-limiting but recurs frequently. Although EPC shares several characteristics with the superficial type of erythema annulare centrifugum or asymmetrical periflexural exanthema, EPC differs from erythema annulare centrifugum in clinical manifestation, showing annular rings composed of grouped, tiny papules, and in the histology of perieccrine inflammation, while it differs from asymmetrical periflexural exanthema by male preponderance, onset age, high relapse rate and unique annular configuration. We discuss EPC as compared with other cutaneous disorders showing annular erythema or similar histopathology and suggest that EPC is a distinct clinical entity.

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“…Pain was an infrequent complaint. The histologic feature characteristic of the early stage of polyarteritis nodosa is neutrophilic infiltration with fibrinoid necrosis involving the muscle coat of medium-sized or small arteries, with more mononuclear cell involvement and fibrosis in the later stage 8,9 ( Table 5). In the biopsy specimens of the present patients with lymphocytic thrombophilic arteritis, arterioles in the deep dermis and superficial subcutis showed intense infiltration of lymphocytes and histiocytes in their muscular walls.…”

Section: Commentmentioning

confidence: 99%

“…Histologically, lesions show luminal fibrin deposition and fibrin thrombi mainly affecting small dermal vessels, producing a segmental hyalinizing vasculopathy (Table 5). 8,9,11 Inflammatory infiltrate is often scant and consists mainly of lymphocytes perivascularly. Disturbances in coagulation or fibrinolysis have been found with increasing frequency in livedoid vasculitis, suggesting a prothrombotic state as the etiology.…”

Section: Commentmentioning

confidence: 99%