The vasoconstrictive effect of dopamine in the isolated, perfused rat kidney after catecholamine depletion

Hj, Augustin; Hg, Baumgarten; Huland, Hartwig; Hp, Leichtweiss

doi:10.1007/bf01852114

Cited by 11 publications

(3 citation statements)

References 16 publications

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“…Previously, evidence had been provided for direct T-B cell recognition, both in vivo [3,61 and in other similarly stringent in vitro systems [26]. It should be noted, however, that "nonspecific" soluble factors have, in fact, been found to induce polyclonal Ig secretion without detectable mitogenicity [27].…”

Section: Discussionmentioning

confidence: 99%

Hapten‐specific helper T cells. II. Genetic determination of functional recognition

Martínez-Alonso¹,

Coutinho

Bernabé³

et al. 1980

Eur J Immunol

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Helper T cells can be raised in CBA mice with specificity for syngeneic spleen cells derivatized with each of the three haptens, trinitrophenyl (TNP), fluorescein isothiocyanate (FITC) and 3‐(p‐sulfophenyldiazo)‐4‐hydroxyphenyl (SP). These helper cells are exquisitely specific for the homologous antigens, since they express helper activity on target B cells derivatized with hapten concentrations 100‐fold lower than those used for priming, while being totally unable to recognize the heterologous hapten modifications. Expression of helper activity, i.e. induction of target B cells, requires the simultaneous recognition of antigen and I‐A‐ or I‐E/C‐encoded determinants directly on the responding B cell surfaces. Helper T cells raised in DBA/2 mice with specificity for the same hapten modifications, while functionally recognizing as efficiently as CBA helper cells densely coupled target cells, fail to interact with syngeneic cells derivatized with low concentrations of any of the three haptens. Furthermore, DBA/2 helper cells show a unique “fine specificity” pattern in that anti‐FITC DBA/2 helpers cross‐react with TNP‐DBA/2 targets.

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Section: Discussionmentioning

confidence: 99%

Hapten‐specific helper T cells. II. Genetic determination of functional recognition

Martínez-Alonso¹,

Coutinho

Bernabé³

et al. 1980

Eur J Immunol

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“…Pendleton & Sherman (1976) found that dopamine does cause a diuresis in the rat, but that this depends on an action on ac-adrenergic receptors. Moreover, Aihara, Kasai & Sakai (1972), Neuvonnen & Westermann (1973) and Augustin, Baumgarten, Huland & Leichtwaub (1977) found that infusions of dopamine cause only vasoconstriction in the rat. We have investigated this topic further and evidence is presented in this paper to show that dopamine can have actions on the renal vascular bed of the rat which are similar to those reported for man and dog.…”

Section: Introductionmentioning

confidence: 99%

The actions of dopamine and of sulpiride on regional blood flows in the rat kidney.

Chapman¹,

Horn²,

Munday³

et al. 1980

The Journal of Physiology

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1. Blood flow was measured in the renal cortex and medulla of anaesthetized rats by the hydrogen washout method. The effects of dopamine infusion were measured. 2. Low doses of dopamine (20 and 65 n‐mole.kg‐1.min‐1) caused only small increases in renal blood flow, and a higher dose (200 n‐mole.kg‐1.min‐1) caused vasoconstriction. After alpha‐blockade with phenoxybenzamine (9 mumole.kg‐1), all doses of dopamine caused vasodilatation in the cortex and medulla of the kidney. 3. This dopamine‐induced renal vasodilatation was almost abolished by sulpiride (0.7 mumole.kg‐1.min‐1), but was only slightly attenuated by propranolol (10 mumole.kg‐1). 4. Sulpiride did not significantly alter the renal blood flow responses to noradrenaline or isoprenaline, or the blood pressure responses to histamine, acetylcholine, 5HT, noradrenaline and isoprenaline. 5. In normal rats, infusion of sulpiride generally caused a reduction in renal cortical blood flow. This response showed a positive correlation with the initial blood pressure. 6. It is concluded that there are specific dopamine receptors in the renal vasculature of the rat, and that dopamine may play a role in the normal control of renal blood flow.

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“…A vasodilator response has also been reported in the intact rat (Greven & Klein, 1977) but not in the cat (Wassermann, Huss & Kullmann, 1980). Studies in the rat isolated perfused kidney have produced conflicting results (Augustin et al, 1977;Woodman & Lang, 1980). In all species dopamine has diuretic and natriuretic effects which can be blocked by specific dopamine receptor antagonists (Wassermann et al, 1980;McGrath & Jablonski, 1981).…”

Section: Introductionmentioning

confidence: 99%

Differentiation of Noradrenergic and Dopaminergic Nerves in the Rat Kidney: Evidence Against Significant Dopaminergic Innervation

McGrath

Lim

Bode

et al. 1983

Clin Exp Pharma Physio

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In the rat kidney catecholaminergic nerve elements were identified by fluorescence histochemistry in perivascular plexuses around corticula arteries and juxtaglomerular arterioles and in medullary vascular bundles. Fluorescence was abolished in all areas 24 h after treatment with 6-hydroxydopamine (6-OHDA; 150 mg/kg i.v.). Protection of noradrenergic endings from destruction by 6-OHDA was afforded by pretreatment with desipramine (DMI; 25 mg/kg i.p.) which restored fluorescence towards control levels. By semiquantitative analysis fluorescence was identical in juxtaglomerular regions but slightly reduced around larger vessels in (DMI + 6-OHDA)-treated rats when compared to controls. Changes in tissue noradrenaline content, but not dopamine content, paralleled the changes in nerve fluorescence. Noradrenaline content was 4.10 pmol/mg protein (s.e.m. = 0.22, n = 32) in controls and was reduced by 90% to 0.40 pmol/mg (s.e.m. = 0.05, n = 23) in 6-OHDA-treated and by 26% to 3.01 pmol/mg (s.e.m. = 0.21, n = 23) in (DMI + 6-OHDA)-treated rats. Kidney dopamine content was 0.38 pmol/mg protein (s.e.m. = 0.05, n = 32) in controls and was reduced by 55% to 0.18 pmol/mg (s.e.m. = 0.02, n = 17) in 6-OHDA-treated and by 53% to 0.17 pmol/mg (s.e.m. = 0.02, n = 23) in (DMI + 6-OHDA)-treated rats. The renin response to haemorrhage was examined in pentobarbitone sodium-anaesthetized rats as a test of functional integrity of renal nerves in the three groups. Progressive 1 ml haemorrhages (to total blood loss of 4 ml, 1.3% body weight) resulted in similar increases in plasma renin activity in controls and (DMI + 6-OHDA)-treated animals but the response was significantly attenuated in 6-OHDA-treated rats. Renal catecholaminergic nerves appear to be predominantly noradrenergic. It is doubtful if a significant intrarenal dopaminergic system exists in the rat.

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The vasoconstrictive effect of dopamine in the isolated, perfused rat kidney after catecholamine depletion

Cited by 11 publications

References 16 publications

Hapten‐specific helper T cells. II. Genetic determination of functional recognition

Hapten‐specific helper T cells. II. Genetic determination of functional recognition

The actions of dopamine and of sulpiride on regional blood flows in the rat kidney.

Differentiation of Noradrenergic and Dopaminergic Nerves in the Rat Kidney: Evidence Against Significant Dopaminergic Innervation

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