The vasorelaxant effect of viscum album leaf extract is nediated by calcium-dependent mechanisms

Mojiminiyi, F.B.O.; Ma, Owolabi; Igbokwe, U V; Ajagbonna, O. P.

doi:10.4314/njps.v23i1-2.54947

Cited by 11 publications

(12 citation statements)

References 16 publications

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“…The prominent impact of V. album on cardiovascular system is the vasorelaxant activity ( 14 - 16 ). In addition, antihypercholesterolaemic effects are demonstrated ( 17 ).…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective effects of Viscum album L. ssp. album (Loranthaceae) on isoproterenol-induced heart failure via regulation of the nitric oxide pathway in rats

et al. 2016

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Objective:Viscum album L. has favorable cardiovascular effects including antihypertensive and vasorelaxant activity, and the nitric oxide (NO) pathway upregulation has been proposed to be the underlying mechanism. NO also plays an important role in the pathophysiology of heart failure. However, its effects on cardiac systolic function are unclear.Methods:A total of 30 male Wistar albino rats at 12 weeks of age were randomly divided into three groups: control, isoproterenol-induced heart failure group (ISO), and isoproterenol-induced heart failure + V. album treatment group (VA) groups (n=10 in each group). V. album was orally given at a dose of 250 mg/kg/day by gavage. Parameters of heart failure were compared among the groups. Tamhane’s T2 test, paired sample t-test, and Bonferroni methods were used for statistical analysis.Results:V. album resulted in an improvement in all parameters of heart failure including left ventricular diameters (6.34±0.23 mm, 6.98±0.35 mm, and 6.71±0.10 mm for left ventricular end-diastolic diameter in control, ISO, and VA groups, respectively, p<0.05), ejection fraction (73.3±3.1%, 56.7±2.6%, and 65.2±1.5% for control, ISO, and VA groups, respectively, p<0.05), serum NT-proBNP levels, and histopathological changes. V. album treatment resulted in a statistically significant attenuation of increased levels of NO and iNOS (p<0.0001). The levels of hs-CRP were also found to be lower in the VA group compared with the controls and ISO groups (p<0.01).Conclusion:V. album exerted favorable effects on left ventricular function in isoproterenol-induced heart failure rats. Upregulation of the NO pathway seems to be the possible pathophysiological mechanism. Favorable vascular outcomes can also be speculated considering the reduction in serum hs-CRP levels.

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“…The prominent impact of V. album on cardiovascular system is the vasorelaxant activity ( 14 - 16 ). In addition, antihypercholesterolaemic effects are demonstrated ( 17 ).…”

Section: Discussionmentioning

confidence: 99%

Cardioprotective effects of Viscum album L. ssp. album (Loranthaceae) on isoproterenol-induced heart failure via regulation of the nitric oxide pathway in rats

et al. 2016

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“…Nevertheless, in vitro studies suggest that Viscum album may act as a natural calcium-channel blocker. 58 Among human subjects with essential hypertension, 30 drops/day for 12 weeks was shown to significantly reduce BP (P<0.0001). 59…”

Section: European Mistletoe (Viscum Album)mentioning

confidence: 98%

An Integrative Approach to Hypertension: A Comprehensive Review of Antihypertensive Nutrients and Botanicals

Adams¹,

González²,

Miranda-Massari³

et al. 2016

j restorat med

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Objective:We conducted a comprehensive review of the most current data available on the antihypertensive effects of 29 different nutraceuticals. Design:In this review, we collected evidence from clinical trials and meta-analyses of clinical trials with human subjects that are representative of the general adult population; studies of infants, children, and pregnant women were excluded. Observational studies were included in some cases as supplementary evidence, and in vitro or animal studies were included only for the purpose of explaining hypotensive mechanisms. PubMed served as the primary search engine. Outcome measures:The efficacy of each nutrient and botanical was demonstrated by a treatment that resulted in a reduction of either systolic or diastolic blood pressure in humans. Results:All of the reviewed botanical and nutrient supplements, with the exception of French maritime pine bark extract and maitake (Grifola frondosa), have been demonstrated to effectively lower blood pressure in humans with good tolerability.Conclusions: Current data supporting the use of nutrients and botanicals in the treatment of blood pressure are encouraging.

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“…Nigerian researchers reported that Viscum interfered with calcium ion-driven vascular contraction; both the influx of calcium and mobilization of calcium in intracellular stores were believed to be affected. 28 Researchers in Serbia reported that hydroethanol extracts of Viscum album were capable of lowering blood pressure in rats, and that the use of muscarinic receptor blockers diminished or totally abolished the hypotensive effects of Viscum. This suggests that Viscum may act via muscarinic nerve transmission.…”

Section: The Use Of Viscummentioning

confidence: 99%

Reversing Hypertension with Rauwolfia, Viscum and Piscidia

Stansbury¹,

Saunders²,

Winston³

et al. 2012

j restorat med

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Rauwolfia, Viscum, and Psicidia are well known herbs used in the treatment of hypertension. These herbs contain several different bioactive constituents including alkaloids, lectins, rotenones, flavonoids and isoflavones, among others, which research indicates as being cardioprotective, promote vascular health and reduce blood pressure. As the mechanisms of action are different for each herb, due to the varying bioactive compounds present, they can be used alone or in combination for these indications. Patients being treated with the above-described herbs need to be carefully monitored, particularly for interactions with any concomitant antihypertensive medication-and herbal doses individually tailored.

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The vasorelaxant effect of viscum album leaf extract is nediated by calcium-dependent mechanisms

Cited by 11 publications

References 16 publications

Cardioprotective effects of Viscum album L. ssp. album (Loranthaceae) on isoproterenol-induced heart failure via regulation of the nitric oxide pathway in rats

Cardioprotective effects of Viscum album L. ssp. album (Loranthaceae) on isoproterenol-induced heart failure via regulation of the nitric oxide pathway in rats

An Integrative Approach to Hypertension: A Comprehensive Review of Antihypertensive Nutrients and Botanicals

Reversing Hypertension with Rauwolfia, Viscum and Piscidia

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