1999
DOI: 10.1208/ps010202
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The venus flytrap of periplasmic binding proteins: An ancient protein module present in multiple drug receptors

Abstract: Located between the inner and outer membranes of Gram-negative bacteria, periplasmic binding proteins (PBPs) scavenge or sense diverse nutrients in the environment by coupling to transporters or chemotaxis receptors in the inner membrane. Their three-dimensional structures have been deduced in atomic detail with the use of X-ray crystallography, both in the free and liganded state. PBPs consist of two large lobes that close around the bound ligand, resembling a Venus flytrap. This architecture is reiterated in… Show more

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Cited by 237 publications
(214 citation statements)
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“…A derivative of this model, equally consistent with the data, has each GLR subunit possessing two binding sites: an LAOBP domain (traditional Glu binding site) and an N-terminal LIVBP-binding domain for other amino acids (Felder et al, 1999; Bouché et al, Figure 6. A, Wild-type and glr3.4 depolarizations in response to the six potent amino acids.…”
Section: Discussionsupporting
confidence: 68%
“…A derivative of this model, equally consistent with the data, has each GLR subunit possessing two binding sites: an LAOBP domain (traditional Glu binding site) and an N-terminal LIVBP-binding domain for other amino acids (Felder et al, 1999; Bouché et al, Figure 6. A, Wild-type and glr3.4 depolarizations in response to the six potent amino acids.…”
Section: Discussionsupporting
confidence: 68%
“…Their agonist-binding domain is homologous to bacterial periplasmic binding proteins involved in the trafficking of ions, amino acids, and sugars in the periplasm of Gram-negative bacteria (7,10,11). This finding was confirmed by the determination of the crystal structure of the metabotropic glutamate receptor 1 (mGlu 1 ) extracellular domain.…”
mentioning
confidence: 72%
“…The periplasmic binding proteins are known to bind their ligand in the periplasmic space and to deliver it to a transmembrane complex responsible for the transport of the molecule inside the bacteria (11,36). Among the hypotheses for the activation mechanism of class-III GPCRs, it was proposed that the VFTM would bind the ligand and deliver it to another site within the HD leading to its activation (37).…”
Section: Discussionmentioning
confidence: 99%
“…1B). It also contained 10 predicted N-glycosylation sites plus a Venus flytrap (VFT) module known from several proteins including a subset of RTKs in insects and other invertebrates (23,24). Quantitative real-time PCR (qRT-PCR) indicated that AAEL001915 expression was higher in the ovaries of 5-d-old nonblood female A. aegypti than in the fat body and midgut (Fig.…”
Section: Significancementioning
confidence: 99%