The Versatile Dioctadecyldimethylammonium Bromide

Carmona-Ribeiro, Ana Maria

doi:10.5772/68020

Cited by 16 publications

(30 citation statements)

References 115 publications

(187 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Such kind of nanoformulations was recommended for topical therapy [68]. Cationic surfactants with double, long-chains exhibited antimicrobial properties [69]. It was confirmed that the determining factor of the antifungal action of cationic surfactants is not cell lysis, but a change in the cell surface from negative to positive charge [70].…”

Section: Antimicrobial Activity and Hemolysis Of Dhdhabmentioning

confidence: 91%

Mixed cationic liposomes for brain delivery of drugs by the intranasal route: The acetylcholinesterase reactivator 2-PAM as encapsulated drug model

Pashirova

Zueva

Петров

et al. 2018

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

Section: Antimicrobial Activity and Hemolysis Of Dhdhabmentioning

confidence: 91%

Mixed cationic liposomes for brain delivery of drugs by the intranasal route: The acetylcholinesterase reactivator 2-PAM as encapsulated drug model

Pashirova

Zueva

Петров

et al. 2018

Colloids and Surfaces B: Biointerfaces

View full text Add to dashboard Cite

“…In summary, cationic micro and nanoparticles are effectively taken up both by macrophages and dendritic cells since electrostatic attraction promotes particle binding and subsequent internalization [11,14,20,24,25]. Cationic particles and liposomes containing dioctadecyldimethylammonium bromide (DODAB) cationic lipid [13,26] carrying Mycobacterium tuberculosis [13,27], Chlamydia trachomatis [11], or Neisseria meningitides antigens enhanced the cellular and humoral immune response against them [16,28].Another important class of cationic adjuvants is represented by the cationic polymers despite their overt cytotoxicity [29][30][31][32][33]. They easily combine with oppositely charged proteins [34].…”

mentioning

confidence: 99%

Simple Nanoparticles from the Assembly of Cationic Polymer and Antigen as Immunoadjuvants

et al. 2020

Self Cite

View full text Add to dashboard Cite

Since antigens are negatively charged, they combine well with positively charged adjuvants. Here, ovalbumin (OVA) (0.1 mg·mL −1 ) and poly (diallyldimethylammonium chloride) (PDDA) (0.01 mg·mL −1 ) yielded PDDA/OVA assemblies characterized by dynamic light scattering (DLS) and scanning electron microscopy (SEM) as spherical nanoparticles (NPs) of 170 ± 4 nm hydrodynamic diameter, 30 ± 2 mV of zeta-potential and 0.11 ± 0.01 of polydispersity. Mice immunization with the NPs elicited high OVA-specific IgG1 and low OVA-specific IgG2a production, indicating a Th-2 response. Delayed-type hypersensitivity reaction (DTH) was low and comparable to the one elicited by Al(OH) 3 /OVA, suggesting again a Th-2 response. PDDA advantages as an adjuvant were simplicity (a single-component adjuvant), low concentration needed (0.01 mg·mL −1 PDDA) combined with antigen yielding neglectable cytotoxicity, and high stability of PDDA/OVA dispersions. The NPs elicited much higher OVA-specific antibodies production than Al(OH) 3 /OVA. In vivo, the nano-metric size possibly assured antigen presentation by antigen-presenting cells (APC) at the lymph nodes, in contrast to the location of Al(OH) 3 /OVA microparticles at the site of injection for longer periods with stimulation of local dendritic cells. In the future, it will be interesting to evaluate combinations of the antigen with NPs carrying both PDDA and elicitors of the Th-1 response.Vaccines 2020, 8, 105 2 of 16 or cationic polymers on superparamagnetic iron oxide NPs [18] have also been proposed as effective micro or nanomaterials able to effectively interact with antigens and antigen-presenting cells (APC).Major mechanisms for taking up the cationic assemblies depend on size [19,20]. Nanoparticles with 20-200 nm mean diameter are like viruses and usually taken up by endocytosis via clathrin-coated vesicles, caveolae, or their independent receptors, and preferentially ingested by dendritic cells (DC) [21]. Microparticles with 500-5000 nm diameter are like bacteria, captured by phagocytosis and primarily ingested by macrophages. All particles used in vaccine formulations are consequently internalized efficiently by APC by one or a combination of the quoted mechanisms [22,23]. Particles with diameters smaller than 500 nm, in particular the nano-sized ones with 40-100 nm diameter, are more efficient to promote CD8 and CD4 type 1 T-helper cells responses than those with diameters above 500 nm; large particles, more similar to Al (OH) 3 , usually induce good T-helper cells type 2 improvement in antibody responses [22]. In summary, cationic micro and nanoparticles are effectively taken up both by macrophages and dendritic cells since electrostatic attraction promotes particle binding and subsequent internalization [11,14,20,24,25]. Cationic particles and liposomes containing dioctadecyldimethylammonium bromide (DODAB) cationic lipid [13,26] carrying Mycobacterium tuberculosis [13,27], Chlamydia trachomatis [11], or Neisseria meningitides antigens enhanced the cellular and humoral immune re...

show abstract

“…In the absence of PMMA, QACs in water dispersion self-assemble to yield micelles or bilayers depending on the QAC chemical structure and molecular shape [32,33]. Dioctadecyl dimethyl ammonium bromide (DODAB) assembles in water solution as bilayer vesicles or bilayer fragments (BF) depending on the dispersion method; sonication disrupts DODAB vesicles producing BF [34][35][36]. Cetyltrimethylammonium bromide (CTAB) assembles in water solution as micelles above the critical micellar concentration [32].…”

Section: Introductionmentioning

confidence: 99%

Hybrid Nanoparticles of Poly (Methyl Methacrylate) and Antimicrobial Quaternary Ammonium Surfactants

Mathiazzi

Carmona-Ribeiro

2020

Pharmaceutics

Self Cite

View full text Add to dashboard Cite

Quaternary ammonium surfactants (QACs) are microbicides, whereas poly (acrylates) are biocompatible polymers. Here, the physical and antimicrobial properties of two QACs, cetyl trimethyl ammonium bromide (CTAB) or dioctadecyl dimethyl ammonium bromide (DODAB) in poly (methyl methacrylate) (PMMA) nanoparticles (NPs) are compared to those of QACs alone. Methyl methacrylate (MMA) polymerization using DODAB or CTAB as emulsifiers and initiator azobisisobutyronitrile (AIBN) yielded cationic, nanometric, homodisperse, and stable NPs. NPs’ physical and antimicrobial properties were assessed from dynamic light scattering (DLS), scanning electron microscopy, and viability curves of Escherichia coli, Staphylococcus aureus, or Candida albicans determined as log(colony-forming unities counting) over a range of [QACs]. NPs were spherical and homodisperse but activity for free QACs was higher than those for QACs in NPs. Inhibition halos against bacteria and yeast were observed only for free or incorporated CTAB in NPs because PMMA/CTAB NPs controlled the CTAB release. DODAB displayed fungicidal activity against C. albicans since DODAB bilayer disks could penetrate the outer glycoproteins fungus layer. The physical properties and stability of the cationic NPs highlighted their potential to combine with other bioactive molecules for further applications in drug and vaccine delivery.

show abstract

The Versatile Dioctadecyldimethylammonium Bromide

Cited by 16 publications

References 115 publications

Mixed cationic liposomes for brain delivery of drugs by the intranasal route: The acetylcholinesterase reactivator 2-PAM as encapsulated drug model

Mixed cationic liposomes for brain delivery of drugs by the intranasal route: The acetylcholinesterase reactivator 2-PAM as encapsulated drug model

Simple Nanoparticles from the Assembly of Cationic Polymer and Antigen as Immunoadjuvants

Hybrid Nanoparticles of Poly (Methyl Methacrylate) and Antimicrobial Quaternary Ammonium Surfactants

Contact Info

Product

Resources

About