2023
DOI: 10.3389/fendo.2023.1189007
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The versatile role of Serpina3c in physiological and pathological processes: a review of recent studies

Abstract: Murine Serpina3c belongs to the family of serine protease inhibitors (Serpins), clade “A” and its human homologue is SerpinA3. Serpina3c is involved in some physiological processes, including insulin secretion and adipogenesis. In the pathophysiological process, the deletion of Serpina3c leads to more severe metabolic disorders, such as aggravated non-alcoholic fatty liver disease (NAFLD), insulin resistance and obesity. In addition, Serpina3c can improve atherosclerosis and regulate cardiac remodeling after m… Show more

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Cited by 4 publications
(3 citation statements)
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References 108 publications
(158 reference statements)
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“…Preadipocyte differentiation would generate new adipocytes. Excessive increase in adipocyte size in obese individuals may reduce the ability of hypertrophic adipocytes to further absorb and store lipids, and white adipose tissue would generate more adipocytes by promoting preadipocyte differentiation to relieve the pressure of storing fat (Li & Guo, 2023). Moderate white adipocyte differentiation helps to ensure homeostasis of energy metabolism, but excessive adipocyte differentiation may be associated with the development of obesity (Guo et al, 2016; Longo et al, 2019).…”
Section: Overview Of Adipocyte Differentiationmentioning
confidence: 99%
See 1 more Smart Citation
“…Preadipocyte differentiation would generate new adipocytes. Excessive increase in adipocyte size in obese individuals may reduce the ability of hypertrophic adipocytes to further absorb and store lipids, and white adipose tissue would generate more adipocytes by promoting preadipocyte differentiation to relieve the pressure of storing fat (Li & Guo, 2023). Moderate white adipocyte differentiation helps to ensure homeostasis of energy metabolism, but excessive adipocyte differentiation may be associated with the development of obesity (Guo et al, 2016; Longo et al, 2019).…”
Section: Overview Of Adipocyte Differentiationmentioning
confidence: 99%
“…Excess adipose tissue and ectopic fat accumulation in the body increase the risk of obesity as well as other metabolic diseases (Guo et al, 2019; Li & Guo, 2023; Piché et al, 2020; Chen et al, 2023). The increase in the number (hyperplasia) and size (hypertophy) of adipocytes is involved in the initiation and progression of obesity (Zhu et al, 2022).…”
Section: Introductionmentioning
confidence: 99%
“…During exercise, a complex cellular and molecular network will be created and regulated, which contribute to the metabolic health effects of exercise 22 25 . Over the past years, a growing body of work has implicated hundreds or even thousands of molecules regulated by exercise that are involved in the regulation of whole-body metabolism 26 30 . Nevertheless, only a few of them had been characterized and had their biological functions in exercise been demonstrated 22 , 23 , 25 .…”
Section: Introductionmentioning
confidence: 99%