The versatile roles of lumican in eye diseases: A review

Tsui, Mei‐Chi; Liu, Hsin‐Yu; Chu, Hsiao-Sang; Chen, Wei-Li; Hu, Fung-Rong; Kao, Winston W.‐Y.; Wang, I‐Jong

doi:10.1016/j.jtos.2023.06.012

Cited by 5 publications

(2 citation statements)

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“…LUM is correlated with retinal degeneration [ 88 ] and is fundamentally involved in retinal homeostasis [ 86 , 89 , 90 ]. The roles of LUM in inherited and acquired eye diseases have been recently reviewed [ 91 ]. A single nucleotide polymorphism in the 5′-regulatory region of the LUM gene ( LUM ) is associated with high myopia in some Asian populations but has a protective effect against myopia in a cohort of English patients [ 91 ].…”

Section: Lumican and Retinal Homeostasismentioning

confidence: 99%

“…The roles of LUM in inherited and acquired eye diseases have been recently reviewed [ 91 ]. A single nucleotide polymorphism in the 5′-regulatory region of the LUM gene ( LUM ) is associated with high myopia in some Asian populations but has a protective effect against myopia in a cohort of English patients [ 91 ]. LUM has roles in age-related macular degeneration and diabetic retinopathy, which are leading causes of visual impairment [ 86 , 89 ].…”

Section: Lumican and Retinal Homeostasismentioning

confidence: 99%

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Lumican, a Multifunctional Cell Instructive Biomarker Proteoglycan Has Novel Roles as a Marker of the Hypercoagulative State of Long Covid Disease

Smith,

Melrose

2024

IJMS

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This study has reviewed the many roles of lumican as a biomarker of tissue pathology in health and disease. Lumican is a structure regulatory proteoglycan of collagen-rich tissues, with cell instructive properties through interactions with a number of cell surface receptors in tissue repair, thereby regulating cell proliferation, differentiation, inflammation and the innate and humoral immune systems to combat infection. The exponential increase in publications in the last decade dealing with lumican testify to its role as a pleiotropic biomarker regulatory protein. Recent findings show lumican has novel roles as a biomarker of the hypercoagulative state that occurs in SARS CoV-2 infections; thus, it may also prove useful in the delineation of the complex tissue changes that characterize COVID-19 disease. Lumican may be useful as a prognostic and diagnostic biomarker of long COVID disease and its sequelae.

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