The vexing urticaria problem: Present concepts of etiology and management

Sheldon, John M.; Mathews, Kenneth P.; Lovell, Robert G.

doi:10.1016/s0021-8707(54)90034-9

Cited by 116 publications

(36 citation statements)

References 229 publications

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“…1,3,4,[7][8][9][10][11][12][13][14][15] Urticaria-angioedema can attack at any age and particularly affects middle-aged women. [1][2][3][4]6,8,10,[12][13][14]16,17 It is estimated that between 12% and 25% of the general population have already had at least one urticaria-angioedema episode 16,17 and that the prevalence among dermatological patients is around 1.85%. 8,18 The illness may have spontaneous resolution, but by detecting the cause(s) and aggravating factor(s) it can be controlled.…”

Section: Introductionmentioning

confidence: 99%

Sociodemographic and clinical characteristics, causal factors and evolution of a group of patients with chronic urticaria-angioedema

et al. 2007

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CONTEXT AND OBJECTIVE: Chronic urticaria-angioedema is a common, multiple-cause complaint. The aim was to investigate the sociodemographic and clinical characteristics, causal and aggravating factors and evolution of urticaria-angioedema. DESIGN AND SETTING: This was a descriptive prospective study carried out at the Dermatology outpatient clinic of Faculdade de Medicina de Botucatu, Universidade Estadual Paulista (Unesp). METHODS: A total of 125 patients with chronic urticaria-angioedema were evaluated to obtain sociodemographic data, anamnesis, dermatological and general clinical data and laboratory data, emphasizing causal and aggravating factors and complaint evolution. RESULTS: Chronic urticaria-angioedema occurred mainly in females (mean age: 35 years), but also in men (mean age: 32 years). White color and living in urban areas also predominated. There was no preferential time for symptoms to appear, and nighttime was the most commonly reported time for clinical worsening. Around half of the patients had urticaria associated with angioedema. There were no associated factors in most of the cases, and stress was the most commonly reported aggravating factor. The cause was ascertained in 37.6% of our cases. The mean duration of follow-up was 11.7 months. Around 60% of the patients evolved with the problem under control, 32% improved, 9% had no change in dermatological condition and only one patient worsened. CONCLUSIONS: Chronic urticaria-angioedema was more common among middle-aged women. It is a long-term disease, and its cause was explained in about one-third of the patients. Half of the patients presented disease control after treatment lasting an average of approximately one year.

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Section: Introductionmentioning

confidence: 99%

Sociodemographic and clinical characteristics, causal factors and evolution of a group of patients with chronic urticaria-angioedema

et al. 2007

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“…It has been estimated that 15% to 23% of the US population will experience acute or chronic urticaria at some point in their lifetime, and there is an approximately 0.5% lifetime prevalence of CIU in the general population. [1][2][3] Chronic idiopathic urticaria more commonly affects women than men (2:1), is more commonly seen in the adult population, 4 and is associated with angioedema in 50% to 90% of cases. 5,6 The discomfort and negative cosmetic impact experienced with chronic urticaria, as well as the elusive pathogenesis and the lack of satisfactory control of symptoms with standard therapies, can be very frustrating for patients and health care providers.…”

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confidence: 99%

Successful Treatment of Recalcitrant Chronic Idiopathic Urticaria With Sulfasalazine

McGirt¹,

Vasagar²,

Gober³

et al. 2006

Arch Dermatol

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“…1 In a study done among college students, 15.7% had a history of urticaria; 9 however, another study reported an incidence of 58.2% among students. 10 A survey of the population in Sweden estimated the prevalence rate of urticaria to be 0.11% in males and 0.14% in females.…”

Section: Prevalence and Incidencementioning

confidence: 98%

“…12 It is difficult to estimate the exact incidence of urticaria in a given population because urticaria is often mild and resolves spontaneously and thus many cases can escape medical attention. 1,11,12 General practitioner statistics showed that 1.4% of their patients had urticaria; 13 in dermatology clinics, urticaria cases represented 1% to 2% of patients.…”

Section: Prevalence and Incidencementioning

confidence: 99%

“…The incidence of urticaria has been estimated to vary from 10% to 25% in the general population. 1 Urticaria is a vascular reaction pattern which can be caused by multiple and diverse factors. These factors activate mast cells as well as other cells (e.g., eosinophils, basophils, neutrophils, endothelial cells and platelets) with the release of their vasoactive and chemotactic mediators of inflammation.…”

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Experience in Urticaria with Patients Attending a Dermatological Clinic in a Referral Center in the Eastern Province of Saudi Arabia

Uthman

El-Nuhdi

1995

Annals of Saudi Medicine

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Urticaria is a common cutaneous vascular reaction pattern caused by diverse and multiple factors. However, an etiologic factor can be established in less than 20% of chronic cases. In this study, 274 patients with urticaria were evaluated in the dermatology clinic of King Fahd Hospital of the University (KFHU) between 1989 and 1992. Saudi nationals predominated; 188 patients were males (68.6%) and 86 were females (31.4%) and the peak incidence of urticaria was in young adults. The incidence of urticaria was 3.79% of dermatological cases. The success rate for identification of etiological factors was 41% in acute urticaria and 14% in chronic urticaria. The etiological categories discovered included allergies, physical factors, infections and miscellaneous systemic factors. In conclusion, causative factors remained elusive in the majority of cases. The identification and removal of the possible causative factors is the most important aspect of management in urticaria. A detailed history and physical examination are in order; however, extensive laboratory investigations are unnecessary. Ann Saudi Med 1995;15(1):10-13. MAE Uthman, M El-Nuhd, Experience in Urticaria with Patients Attending a Dermatological Clinic in a Referral Center in the Eastern Province of Saudi Arabia. 1995; 15(1): 10-13Urticaria is a common cutaneous eruption characterized by evanescent, pruritic and slightly erythematous plaques or papules. The incidence of urticaria has been estimated to vary from 10% to 25% in the general population.1 Urticaria is a vascular reaction pattern which can be caused by multiple and diverse factors. These factors activate mast cells as well as other cells (e.g., eosinophils, basophils, neutrophils, endothelial cells and platelets) with the release of their vasoactive and chemotactic mediators of inflammation. 2,3 Histamine is the best known mediator of increased vascular permeability and itching in urticaria; however, serum factors, kinins, fibrin degradation products, leukotriens and various enzymes have also been recognized to play a pathogenic role in urticaria. 3,4 Therefore, the pathogenetic mechanism involved in urticaria can be classified as either immunological or nonimmunological reactions. 5,6 In clinical practice, an urticarial eruption can easily be diagnosed; however, finding the etiological factor(s) involved can be difficult and impossible in the majority of cases.7 To the best of our knowledge, reports of urticaria from the Middle East and in particular from Saudi Arabia are unavailable. This study was undertaken to highlight the prevalence of urticaria and to evaluate its etiological factors involved in patients referred to our dermatology clinic. Patients and MethodsWe interviewed and reviewed all patients with urticaria seen consecutively at the dermatology clinic of King Fahd Hospital of the University (KFHU) in Al-Khobar from 1989 to 1992. The number of patients forming the basis of our statistical analysis was 274 and the case records of 34 patients were excluded for either an incorrect or a ...

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The vexing urticaria problem: Present concepts of etiology and management

Cited by 116 publications

References 229 publications

Sociodemographic and clinical characteristics, causal factors and evolution of a group of patients with chronic urticaria-angioedema

Sociodemographic and clinical characteristics, causal factors and evolution of a group of patients with chronic urticaria-angioedema

Successful Treatment of Recalcitrant Chronic Idiopathic Urticaria With Sulfasalazine

Experience in Urticaria with Patients Attending a Dermatological Clinic in a Referral Center in the Eastern Province of Saudi Arabia

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