The Viral Etiology of AIDS‐Associated Malignancies

Angeletti, Peter C.; Zhang, Luwen; Wood, Charles

doi:10.1016/s1054-3589(07)56016-3

Cited by 66 publications

(48 citation statements)

References 294 publications

(274 reference statements)

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“…HHV-8 contains homologues of cellular genes which stimulate cell proliferation, inflammation and angiogenesis and suppress apoptosis as well. [4][5][6] Other factors predisposing to the formation of KS include gender, immunosuppression, cytokine activation and genetic predisposition. [6] In our patient, the immunohistological examinations that would explain the etiology have revealed HHV-8-positivity.…”

Section: Discussionmentioning

confidence: 99%

Scrotal Kaposi's Sarcoma in HIV-negative patient: A case report and review of the literature

Yenice

Varnalı

Şeker

et al. 2018

Turkish Journal of Urology

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Kaposi's Sarcoma (KS) is a malignancy that generally effects the skin, and can be systemic with internal organ involvement. It originates from the vascular endothelium. KS's relationship with human immunodeficiency virus (HIV) infection is well known. Isolated scrotal KS in the urogenital system is quite rare and scrotal KS in an HIV-negative patient is limited to a few cases. In this case report, the biopsy result from the violescent nodular lesions on the scrotum of the HIV-negative 81-year-old patient was found compatible with KS and a pathology was not detected in the systemic screening. With a diagnosis of isolated scrotal KS, the patient underwent surgical excision aimed at the lesions on the scrotum. KS is rare in HIV-negative patients and it is associated with human herpes virus-8 infection.

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Section: Discussionmentioning

confidence: 99%

Scrotal Kaposi's Sarcoma in HIV-negative patient: A case report and review of the literature

Yenice

Varnalı

Şeker

et al. 2018

Turkish Journal of Urology

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“…KSHV infection can lead to transformation of endothelial cells and phenotypic changes that induce the cells to resemble tumor spindle-cells (93). KSHV encodes a number of viral genes, including homologues of cellular genes, that can affect cell signaling, deregulate the cell cycle, and stimulate angiogenesis, leading to the development of malignancies (see Table 1-1 for a summary of their functions) (reviewed in (13,14,37,280,319)). Saliva largely accounts for KSHV transmission, and unlike most other human herpesviruses, KSHV infection is not universal within the world's population.…”

Section: Kaposi's Sarcoma Associated Herpesvirusmentioning

confidence: 99%

“…Iatrogenic or transplant-associated, KS affects individuals on immunosuppressive therapy ( (89,104,287) and reviewed in (13,14)). Median time from organ transplant to KS diagnosis is anywhere from 2 months to eight years (reviewed in (13)).…”

Section: Kaposi's Sarcomamentioning

confidence: 99%

“…Median time from organ transplant to KS diagnosis is anywhere from 2 months to eight years (reviewed in (13)). Iatrogenic KS may or may not be associated with cutaneous lesions, but can be aggressive affecting mucosa, visceral organs, and lymph nodes in a large percentage of patients (reviewed in (14)).…”

Section: Kaposi's Sarcomamentioning

confidence: 99%

“…EBV infection can lead to mononucleosis, nasopharyngeal carcinoma, Burkitt's lymphoma (reviewed in (171)), the AIDS-related malignancies leiomyosarcoma, Hodgkin's disease, and non-Hodgkin's lymphoma (NHL) (reviewed in (13,338)). Kaposi's sarcomaassociated herpesvirus (KSHV) is a γ2 herpesvirus and the causative agent of Kaposi's sarcoma (KS), as well as two B-cell malignancies, multicentric Castleman's disease (MCD) (297) and primary effusion lymphoma (PEL) (reviewed in (46)).…”

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confidence: 99%

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Role of RRV ORF52 in Virion Maturation

Anderson¹

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Rhesus monkey rhadinovirus (RRV) is a close relative of the human pathogen, Kaposi's Sarcoma-Associated Herpesvirus (KSHV). Primary infection with KSHV in culture is highly inefficient and it predominantly adopts a latent phenotype, expressing only a minimal number of viral genes and producing no progeny virions. This contrasts with RRV in culture, which replicates to high viral titer and produces abundant progeny virions, making it a useful model to study gammaherpesvirus lytic replication, virion structure, and the potential roles of tegument proteins in the biology of gammaherpesviruses. Initial work in our laboratory determined that the RRV virion was composed of 33 virally encoded proteins. Of these, 17 are tegument proteins, five of which are unique to the gammaherpesvirus subfamily. ORF52 is one of these five gammaherpesvirus specific tegument proteins and is the focus of this dissertation. This protein is highly abundant within the virion (approximately 1000 copies per particle) and it is closely associated with the capsid. Our results describe a critical role for ORF52 in the cytoplasmic-based later stages of virion morphogenesis. Without ORF52, capsids fail to undergo tegumentation, which is necessary for final envelopment and production of fully infectious virions. In a later section of this dissertation, we also describe preliminary data proposing that ORF52 may play a direct or indirect role in virion transport through interaction with cellular microtubules.iii ACKNOWLEDGEMENTS I grew up in a small, blue-collar, southern Illinois town where most people stay local and focus on getting by day-to-day, not on things like big cities and advanced degrees. I didn't even know what "graduate school" was until several years into my undergraduate education in Chicago, which, by the way, took me 9 years to complete because I worked full-time and went to school off-and-on and part-time when time and money permitted. The reason I share this is because I didn't get here alone, I didn't even know where "here" was and if I'm honest, I don't think I ever really believed I would earn a PhD, because where I'm from, things like that just don't happen to people like me. There truly are so many people I am honored to thank for helping, and supporting, me at various points in this long, wonderful, horrible, amazing, and trying journey that has been the last 10 years of my life, 7 of those at UVa.

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