The viscoelastic, hyperelastic and scale dependent behaviour of freshly excised individual skin layers

Crichton, Michael L.; Donose, Bogdan C.; Chen, Xianfeng; Raphael, Anthony P.; Huang, Han; Kendall, M. A. F.

doi:10.1016/j.biomaterials.2011.03.012

Cited by 146 publications

(119 citation statements)

References 71 publications

Supporting

Mentioning

111

Contrasting

Unclassified

Order By: Relevance

“…Se han utilizado tres tipos principales de ecuaciones constitutivas para poder determinar correctamente las propiedades mecánicas de la piel, las cuales corresponden con comportamientos: lineal [29], [20], [30], [31]; hiperelástico [25], [32], [33], [34] y viscoelástico [35], [36], [37], [38].…”

Section: La Pielunclassified

Influencia de los Parámetros Tribológicos en el Coeficiente de Fricción entre Polipropileno y Piel

2014

View full text Add to dashboard Cite

ResumenSe adquirieron los datos sobre la topología superficial de sockets para amputados transfermorales utilizando un microscopio de fuerzas atómicas (AFM), se caracterizaron las propiedades tribológicas de 12 zonas significativas, a partir de estos datos se crearon superficies virtuales con geometría sinusoidal de 250m de área, las cuales fueron empleadas para llevar a cabo una simulación numérica para encontrar cual era la relación entre dichos parámetros y el coeficiente de fricción entre el polipropileno del socket y la piel. La piel se modeló como un material híper-elástico y el polipropileno como un material elástico lineal, se impuso un desplazamiento inicial de contacto y un desplazamiento tangencial de las probetas para calcular el coeficiente de fricción, adicionalmente, se aplicó una presión a la parte superior de las probetas de polipropileno que simulan las presiones generadas por el calzado de la prótesis y las fuerzas generadas durante la fase de apoyo de la marcha humana. Se encontró que existe una correlación entre los 1

show abstract

Section: La Pielunclassified

Influencia de los Parámetros Tribológicos en el Coeficiente de Fricción entre Polipropileno y Piel

2014

View full text Add to dashboard Cite

show abstract

“…from whole tissue level in tension (Edwards and Marks 1995;Shergold et al 2006;Kvistedal and Nielsen 2009;Zhou et al 2010;Jor et al 2011) and compression (Wu et al 2007) to nanometer level by indentation, i.e. using atomic force microscopy (AFM) (Crichton et al 2011(Crichton et al , 2013. The viscoelasticity of skin can be observed by experiments designed to study stress relaxation (Lynch et al 2003) and creep (Prete et al 2004), as well as by varying the strain rate (SR) (Haut 1989;Arumugam et al 1994;Silver et al 2002;Shergold et al 2006;Zhou et al 2010).…”

Section: Introductionmentioning

confidence: 96%

Resolving the viscoelasticity and anisotropy dependence of the mechanical properties of skin from a porcine model

Wong

Joyce

Goh

2015

Biomech Model Mechanobiol

View full text Add to dashboard Cite

The mechanical response of skin to external loads is influenced by anisotropy and viscoelasticity of the tissue, but the underlying mechanisms remain unclear. Here, we report a study of the main effects of tissue orientation (TO, which is linked to anisotropy) and strain rate (SR, a measure of viscoelasticity), as well as the interaction effects between the two factors, on the tensile properties of skin from a porcine model. Tensile testing to rupture of porcine skin tissue was conducted to evaluate the sensitivity of the tissue modulus of elasticity (E) and fracture-related properties, namely maximum stress (σU) and strain (εU) at σU, to varying SR and TO. Specimens were excised from the abdominal skin in two orientations, namely parallel (P) and right angle (R) to the torso midline. Each TO was investigated at three SR levels, namely 0.007-0.015 s(-1) (low), 0.040 s(-1) (mid) and 0.065 s(-1) (high). Two-factor analysis of variance revealed that the respective parameters responded differently to varying SR and TO. Significant changes in the σU were observed with different TOs but not with SR. The εU decreased significantly with increasing SR, but no significant variation was observed for different TOs. Significant changes in E were observed with different TOs; E increased significantly with increasing SR. More importantly, the respective mechanical parameters were not significantly influenced by interactions between SR and TO. These findings suggest that the trends associated with the changes in the skin mechanical properties may be attributed partly to differences in the anisotropy and viscoelasticity but not through any interaction between viscoelasticity and anisotropy.

show abstract

“…In recent years, these microneedles have been designed with a wide variety of geometries. The influence of the geometry on their penetration properties has been recently examined (Donnelly et al 2010;Crichton et al 2011;Römgens et al 2014). However, little is known about the influence of this geometry and the microneedle arrangement within an array on the potency of the induced immune response; how the geometry influences the distribution of antigens in the skin, or the binding and internalization by cells, and the subsequent activation of antigen presenting cells (APCs) residing in the skin.…”

Section: Introductionmentioning

confidence: 99%

Predicting the optimal geometry of microneedles and their array for dermal vaccination using a computational model

Römgens

Bader

Bouwstra

et al. 2016

Computer Methods in Biomechanics and Biomedical Engineering

View full text Add to dashboard Cite

a a soft tissue Biomechanics and engineering, department of Biomedical engineering, eindhoven university of technology, eindhoven, the netherlands; b Faculty of health sciences, university of southampton, southampton, uK; c division of drug delivery technology, leiden academic Centre for drug research, leiden university, leiden, the netherlands ABSTRACT Microneedle arrays have been developed to deliver a range of biomolecules including vaccines into the skin. These microneedles have been designed with a wide range of geometries and arrangements within an array. However, little is known about the effect of the geometry on the potency of the induced immune response. The aim of this study was to develop a computational model to predict the optimal design of the microneedles and their arrangement within an array. The three-dimensional finite element model described the diffusion and kinetics in the skin following antigen delivery with a microneedle array. The results revealed an optimum distance between microneedles based on the number of activated antigen presenting cells, which was assumed to be related to the induced immune response. This optimum depends on the delivered dose. In addition, the microneedle length affects the number of cells that will be involved in either the epidermis or dermis. By contrast, the radius at the base of the microneedle and release rate only minimally influenced the number of cells that were activated. The model revealed the importance of various geometric parameters to enhance the induced immune response. The model can be developed further to determine the optimal design of an array by adjusting its various parameters to a specific situation.

show abstract

The viscoelastic, hyperelastic and scale dependent behaviour of freshly excised individual skin layers

Cited by 146 publications

References 71 publications

Influencia de los Parámetros Tribológicos en el Coeficiente de Fricción entre Polipropileno y Piel

Influencia de los Parámetros Tribológicos en el Coeficiente de Fricción entre Polipropileno y Piel

Resolving the viscoelasticity and anisotropy dependence of the mechanical properties of skin from a porcine model

Predicting the optimal geometry of microneedles and their array for dermal vaccination using a computational model

Contact Info

Product

Resources

About