The Visual Cortex during Chronic Stimulation

Dawson, William W.

doi:10.1159/000125577

Cited by 9 publications

(3 citation statements)

References 6 publications

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“…There are only a few reports on neocortical kindling. Moreover, there have been some arguments whether kindling can be developed by stimulations to the visual cortex (Racine, 1975;Harrison and Dawson, 1977). Although it needed more trials and higher intensity of stimulation than amygdaloid kindling, we demonstrated in cats that daily electrical stimulation to the primary visual cortex brought a similar progress of seizure development as in amygdaloid kindling (Baba et al, 1980).…”

mentioning

confidence: 55%

Facilitatory Effects of Intermittent Photic Stimulation on Visual Cortical Kindling

Baba

1982

Epilepsia

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There are few reports on kindling preparation by daily electrical stimulation to the primary visual cortex. In our previous studies on cats, it was demonstrated that repeated stimulation to the primary visual cortex brought a similar progress in seizure development as in amygdaloid kindling, although it took more trials. In this study, we examined the effects of intermittent photic stimulation (IPS) (2.5 Hz) on the visual cortical kindling preparation to clarify more underlying mechanisms of photosensitivity. Under IPS, afterdischarges synchronizing to IPS were seen and a duration of afterdischarge was extremely prolonged, even in the early stage of the kindling process. The threshold of stimulus intensity inducing afterdischarge was significantly reduced and the generalized convulsive seizure was obtained with fewer times of stimulation, as compared to visual cortical kindling without IPS. In visual cortical kindling myoclonic responses were sometimes caused by IPS for a few minutes immediately after cessation of the electrically induced generalized seizure. Such phenomena were never seen in amygdaloid kindling. These results indicate that IPS facilitates a seizure development in all stages of visual cortical kindling.

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mentioning

confidence: 55%

Facilitatory Effects of Intermittent Photic Stimulation on Visual Cortical Kindling

Baba

1982

Epilepsia

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“…The impedance of the stimulating electrodes should be periodically monitored as they reflect changes at the electrode-tissue interface due to, for example, the degree of fibrous tissue and bone formation or an increase in the surface area of the electrodes as a result of Pt dissolution (Babb et al 1977;Harrison and Dawson 1977;Agnew et al 1983).…”

Section: Monitoring Impedance In Vivo and In Vitromentioning

confidence: 99%

Cochlear Implants

Clark¹

2003

285

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“…The histological and physiological re sults are reported in companion papers [2,8]. The effect of charge trans fer on selected candidate metallic electrode materials is presented below.…”

Section: Introductionmentioning

confidence: 99%

An <i>in vitro </i>Analysis of Metal Electrodes for Use in the Neural Environment

Johnson

Hench²

1977

Brain Behav Evol

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The results of evaluation of the corrosion response of Pt, Au, Rh, Ir, Pt-10% Ir and Pt-10% Rh electrodes subjected to bipolar current pulses of 0.1 and 1.0 A/geom. cm² in a simulated neural environment are reported. The criteria for evaluation include the extent and morphology of material removal and corrosion product formation. The chemical changes on the electrode surface and in the test electrolyte are also evaluated. Modified potentiographic methods were developed which monitor interface conditions of the electrodes during chronic, long-term bi-phasic current passage. Under the test conditions established by the neural model, evaluation of the corrosion response of the candidate electrode materials shows that Rh was moderately damaged at 1.0 A/geom. cm², while the remaining test electrodes were severely damaged at this current density. While Rh, Ir and Au exhibit corrosion resistance at 0.1 A/geom. cm², damage to all of the test materials preclude their use in any long-term chronic neural prosthetic implant under the simulated stimulation parameters of the tests. The relative corrosion resistance of the test electrode materials is related to the adherence and coherence of the corrosion product produced on the electrode surface during the first few hundred hours of stimulation. Analysis of the voltage response of the electrodes to current passage provides a means of monitoring the nucleation and growth of the corrosion product.

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The Visual Cortex during Chronic Stimulation

Cited by 9 publications

References 6 publications

Facilitatory Effects of Intermittent Photic Stimulation on Visual Cortical Kindling

Facilitatory Effects of Intermittent Photic Stimulation on Visual Cortical Kindling

Cochlear Implants

An <i>in vitro </i>Analysis of Metal Electrodes for Use in the Neural Environment

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