Many studies have attempted to understand which individual differences may be related to the symptoms of discomfort during the virtual experience (simulator sickness) and the generally considered positive sense of being inside the simulated scene (sense of presence). Nevertheless, due to the quick technological advancement in the field of virtual reality, most of these studies are now outdated. Advanced technology for virtual reality is commonly mediated by head-mounted displays (HMDs), which aim to increase the sense of the presence of the user, remove stimuli from the external environment, and provide high definition, photo-realistic, three-dimensional images. Our results showed that motion sickness susceptibility and simulator sickness are related and neuroticism may be associated and predict simulator sickness. Furthermore, the results showed that people who are more used to playing video-games are less susceptible to simulator sickness; female participants reported more simulator sickness compared to males (but only for nausea-related symptoms). Female participants also experienced a higher sense of presence compared to males. We suggests that published findings on simulator sickness and the sense of presence in virtual reality environments need to be replicated with the use of modern HMDs.