The visual evoked potential in acute primary angle closure glaucoma.

Mitchell, Keith; Wood, Christopher; Howe, J W; Church, William H.; Smith, Gabriella; Spencer, Stephen

doi:10.1136/bjo.73.6.448

Cited by 8 publications

(4 citation statements)

References 34 publications

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“…Особое значение при глаукоме отводится зрительным вызванным потенциалам (ЗВП), которые представляют собой биопотенциалы главным образом зрительной коры головного мозга с вкладом подкорковых образований, а также ганглиозных клеток сетчатки (ГКС), возникающие в ответ на световое возбуждение сетчатки [2]. Исследования, проведенные у больных с первичной открытоугольной глаукомой (ПОУГ), свидетельствуют о том, что уже на ранних стадиях заболевания происходят отклонения в показателях ЗВП [3]. ГКС наиболее чувствительны к ишемии и реперфузии, а потому рано вовлекаются в глаукомный процесс [4].…”

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Pattern visual evoked potentials and their relation to the peripapillary and retrobulbar blood flow in glaucoma

Kurysheva¹,

Маслова²,

Trubilina³

et al. 2018

Vestn. oftal'mol.

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Pattern visual evoked potentials and their relation to the peripapillary and retrobulbar blood flow in glaucoma

Kurysheva¹,

Маслова²,

Trubilina³

et al. 2018

Vestn. oftal'mol.

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“…Glaucoma is characterised by progressive loss of retinal ganglion cells and their axons. Any interruption of the transportation of the electrical pulses, which start from the ganglion cells to the cerebral cortex, can be monitored through the use of VEP 28. Our work provided electrophysiological evidence for differences in the processing of different contrast information in the early stage of POAG mediated by ic-VEP.…”

Section: Discussionmentioning

confidence: 83%

Early impairment of magnocellular visual pathways mediated by isolated-check visual evoked potentials in primary open-angle glaucoma: a cross-sectional study

Ye,

Xu,

Chen

et al. 2024

BMJ Open Ophth

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ObjectiveTo explore different performances in the magnocellular (MC) and parvocellular (PC) visual pathways in patients with primary open-angle glaucoma (POAG) and to objectively assess impairment in early stage of POAG.Methods and analysisThis is a cross-sectional study. MC and PC visual pathways were assessed using isolated-check visual evoked potential (ic-VEP). Visual acuity, intraocular pressure, fundus examination, optical coherence tomography and visual field were measured. Signal-to-noise ratios (SNRs), mediated by ic-VEP were recorded. The Spearman’s correlation analysis was used to estimate the relationships between visual functions and structures. Receiver-operating-characteristic (ROC) curves were used to estimate the accuracy in detection of early POAG.Results60 participants (30 early POAG eyes and 30 age-matched control subjects) were recruited. MC visual pathway showed a non-linear response function, while PC visual pathway was a linear response function as contrast increased. Early POAG eyes exhibited significantly weaker initial contrast gains and lower maximum responses in the MC visual pathway (p=0.001, p=0.004, respectively). The SNRs at 8% and 32% depths of modulation (DOM) were significantly correlated with temporal-side retinal nerve fibre layer (RNFL) thickness in early POAG in MC-biased stimulation (p=0.017, p=0.020, respectively). The areas under ROC of 16% DOM were 0.780 (sensitivity 80.0%, specificity 63.3%) with the cut-off SNR of 2.07.ConclusionsThe MC visual pathway was damaged in the early stage of POAG. The SNRs at 8% and 32% DOM of MC-biased stimulation were significantly correlated with temporal-side RNFL thickness in early POAG, which helped in understanding the mechanisms of visual impairment in the early stage of POAG.

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“…The electrical pulses from the ganglion cells are transmitted to the cerebral cortex via the optic nerve, optic tract, lateral geniculate nucleus, and the optic radiations. Any interruption of the transmission of these electrical pulses can be monitored using VEP [6]. Glaucoma affects the parvocellular and magnocellular cells at the same rate; however, the parvocellular cells contribute 80% of the total ganglion cell population while magnocellular cells make up only 10% [7,8].…”

Section: The Testmentioning

confidence: 99%

“…Glaucoma affects the parvocellular and magnocellular cells at the same rate; however, the parvocellular cells contribute 80% of the total ganglion cell population while magnocellular cells make up only 10% [7,8]. Since the ratio of healthy magnocellular cells compared to the total magnocellular -cell population approaches zero much faster than the parvocellular -cell ratio, isolation of the magnocellular -cell group by specific VEP stimuli may be beneficial in detecting early disease [6].…”

Section: The Testmentioning

confidence: 99%