Two experiments were performed to study the effects of varying the exposure-time and the dissolve-time in the use of a lap-dissolve control unit in presenting programmes intended to teach 14-15-year-old students to visualise the effects of performing reflections and rotations on molecules represented in diagrams. Both experiments employed a two-dimensional design with three levels for each of the two factors. The Rotations Programme was not effective with any of the combinations of exposure-and dissolve-times. The effectiveness of the Reflections Programme showed a significant U-shaped relationship as the exposure-time changed from 5 through 7.5 to 10 seconds. There was no significant effect involving dissolve-time.In all the natural sciences there are topics which require students to visualise the effects of performing spatial operations on three-dimensional structures as represented in diagrams. For example, in order to understand the ideas of three-dimensional symmetry-a recurring theme which pervades many subjects-students should be able to visualise rotations, reflections and inversions. However, Seddon, Tariq & Santos Veiga (1982) have reported the results of an investigation which demonstrated that high proportions (i.e. 17-73%) of very able science students in English sixth-forms and a Portuguese university were unable to perform these tasks satisfactorily on diagrams of molecules. For example, such students were unable to understand that the lower diagrams in Fig. 1 represented the structures in the upper diagrams after rotation about the three Cartesian axes respectively. These results have alarming implications, and it is obviously necessary to devote considerable effort in devising special teaching methods which can be used, either in a remedial way for students in sixth-forms and universities, or as an integral part of lower levels of the curriculum.Two different methods of teaching students to visualise rotations have recently been described by Seddon, Eniaiyeju & Jusoh (1984), who reported successful results with Nigerian students at college and university level. In one method, students were required to observe real models actually rotating, and simultaneously to 189