The vital necessity of adrenal cortical tissue in a mammal and the effects of proliferation of cortical cells from dormant coelomic mesothelium

Pituitary choristoma composed of corticotrophs and adrenocortical cells in the sella turcica

“…Organogenesis of an intracranial adrenal gland was explained by Wiener et al [22] as representing either misplaced blastomere or conversion of fatty tissue to adrenocortical cells. Studies in man [10] and experimental animals [2,7,11] lead to the hypothesis that continued paracrine ACTH stimulation by corticotroph adenoma cells may transform uncommitted stem cells including mesenchymal cells or adipose cells to adrenocortex-like cells. The most plausible explanations are that either uncommitted stem cells such as undifferentiated mesenchymal cells are present in the pituitary region which under prolonged ACTH stimulation can differentiate into adrenocortical cells or adrenocortical cells migrate to a wrong place, the sellar region, during an early embryonic stage.…”

“…The most plausible explanations are that either uncommitted stem cells such as undifferentiated mesenchymal cells are present in the pituitary region which under prolonged ACTH stimulation can differentiate into adrenocortical cells or adrenocortical cells migrate to a wrong place, the sellar region, during an early embryonic stage. Thus, it is conceivable that the adrenocortical tissue can differentiate from various sources [11]. Increased large basophilic or chromophobic vacuolar cells immunopositive for ACTH are well known in the pituitary of untreated Addison's disease but they possess no features of adrenocortical cells [6,18].…”

The incidence of accessory adrenocortical bodies in Rousettus aegyptiacus E. Geoffroy (Megachiroptera : Mammalia)

“…Accessory adrenocortical tissue may arise at any time from coelomic epithelial cells as has been found in rats, mice and man (MacFarland, 1945;Deane, 1962). The cumulative effect of such a process would mean more accessory bodies Brought to you by | University of Arizona Authenticated Download Date | 6/9/15 12:33 PM in older animals than in young ones.…”

“…This was found to be due to the development of new adrenocortical-like tissue in the ovarian stroma and mesovarium (Groat, 1944). With similar treatment, functional accessory adrenal tissue developed in adrenalectomized golden hamsters (Schroeder and Bohle, 1957) and rats (MacFarland, 1945). Where these adrenal bodies naturally occur frequently, or develop easily and quickly, they permit an unusually high percentage of survival after bilateral adrenalectomy (Gaunt, 1933;Gaunt, Gaunt and Tobin, 1935 ;Groat, 1944;Deane, 1962).…”

The Ovary of the 13-Lined Ground Squirrel (Citellus Tridecemlineatus Mitchell) After Adrenalectomy

“…Gruenwald (19426) regarded the mesothelium as particularly pluripotent, so that structural changeability of coelomic derivatives might be discerned even in the adult. This hypothesis is not widely accepted and only MacFarland (1945) has been confident that, after adrenalectomy, there was proliferation of adrenocortical cells from dormant coelomic mesothelium. There may be, however, regeneration of the ovary after total ovariectomy (Parkes, Fielding & Brambell, 1927) and from time to time, in different laboratories, adrenalectomized rats show unexpected survival times (e.g.…”