1966
DOI: 10.1016/0304-4165(66)90167-x
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The vitamin B12-binding protein in human leukocytes

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Cited by 74 publications
(38 citation statements)
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“…c BSA, bovine serum albumin. myeloproliferative disorders, and hypereosinophilic syndrome, none of these were present in our patient (3)(4)(5)(6)(7)(8)(9)(10)(11). These clinical conditions are characterized by high myeloid cell mass and turnover associated with maturation (21,22 ).…”
Section: Discussionmentioning
confidence: 59%
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“…c BSA, bovine serum albumin. myeloproliferative disorders, and hypereosinophilic syndrome, none of these were present in our patient (3)(4)(5)(6)(7)(8)(9)(10)(11). These clinical conditions are characterized by high myeloid cell mass and turnover associated with maturation (21,22 ).…”
Section: Discussionmentioning
confidence: 59%
“…Vitamin B 12 in serum is bound to 2 proteins, transcobalamin (TC) 3 II and haptocorrin (HC). TC is a 43-kDa nonglycosylated serum protein that is synthesized primarily in the enterocytes and is essential for the transport of vitamin B 12 from ileum into the blood and then into most cells via receptor-mediated endocytosis (1,2 ).…”
mentioning
confidence: 99%
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“…They considered that a disintegration product from mature neutrophils contributed to the increased vitamin B12 binding capacity of serum in myeloproliferative disease. However, it was not until 1964 that the presence of a vitamin B12 binding protein in white cells was demonstrated (Simons, 1964;Simons and Weber, 1966). It has been postulated recently (Retief, Cottlieb, Kochwa, Pratt and Herbert, 1967) that leucocytes may be the source of vitamin B12 binding a and fS globulins, and that the myeloid leukaemic granulocyte may give rise to more of the vitamin B12 binding a globulin and less of the j8 globulin than is dehvered into the normal serum by normal granulocytes.…”
Section: Disgussionmentioning
confidence: 99%
“…While no satisfactory explanation has been advanced for these phenomena so far, the possible implication of white cells has been under consideration for some years (Thomas and Anderson, 1956;Fahey, McCoy and Goulian, 1958;Mendelsohn, Watkin, Horbett and Fahey, 1958;Kidd and Thomas, 1962;Meyer, Cronkite, Miller, Mulzac and Jones, 1962;Simons, 1964;Simons and Weber, 1966).…”
Section: Introductionmentioning
confidence: 99%