The Vitamin D Binding Protein DBP

Bouillon, Roger

doi:10.1016/b978-0-12-381978-9.10005-8

Cited by 32 publications

(42 citation statements)

References 135 publications

(122 reference statements)

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“…Vitamin D status in older women is influenced by a decline of renal function with aging, greater adiposity, poor sunlight exposure, and/or lower dietary vitamin D intake (2–4). In addition, availability of serum 25OHD and its metabolites are regulated by DBP (11). Studies have reported a positive correlation between serum 25OHD concentrations and DBP levels (19,22).…”

Section: Discussionmentioning

confidence: 99%

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Vitamin D-Binding Protein in Healthy Pre- and Postmenopausal Women: Relationship with Estradiol Concentrations

et al. 2015

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Objective To examine the relationship between endogenous serum estradiol and vitamin D–binding protein (DBP) and total, free, and bioavailable 25-hydroxyvitamin D (25OHD) concentrations in pre- and postmenopausal women. Methods In 165 healthy women (ages, 26 to 75 years) not taking any form of exogenous estrogen, the serum concentrations of estradiol, 25OHD, DBP, parathyroid hormone, and albumin were measured. Free and bioavailable 25OHD (free + albumin-bound) levels were calculated from total 25OHD, DBP, and serum albumin levels. Results Premenopausal women had higher serum 25OHD (31.5 ± 7.9 ng/mL), DBP (45.3 ± 6.2 mg/dL), and estradiol (52.8 ± 35.0 pg/mL) levels than postmenopausal women (26.5 ± 4.9 ng/mL, 41.7 ± 5.7 mg/dL, and 12.9 ± 4.9 pg/mL), respectively. In addition, the calculated free and bioavailable 25OHD levels were higher in pre- than postmenopausal women (P<.05). Serum estradiol correlated with DBP (r = 0.22; P<.01) and total 25OHD (r = 0.27; P<.01). In multivariate regression models (with or without serum 25OHD), estradiol was independently associated with DBP (P<.05). Conclusion Lower estradiol level is one of the factors that contribute to lower DBP levels in older women. Our data indicate that besides well-known factors such as age, gender, and race, serum estradiol concentrations are also a physiologic predictor of DBP concentration.

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Section: Discussionmentioning

confidence: 99%

“…DBP protects vitamin D metabolites from hydroxylase-mediated catabolism, affects their cellular uptake, and modulates their biologic activity. It is assumed that serum DBP concentrations (much higher than that of its ligands) and binding properties would affect serum free metabolite concentrations (11). …”

Section: Introductionmentioning

confidence: 99%

Vitamin D-Binding Protein in Healthy Pre- and Postmenopausal Women: Relationship with Estradiol Concentrations

et al. 2015

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“…UVB radiation catalyzes conversion of 7-dehydrocholesterol to previtamin D, which then thermally converts to vitamin D. Excessive sun exposure degrades previtamin D and vitamin D into inactive photoproducts (1 ). Vitamin D compounds predominantly bind to DBP, and to a lesser extent to albumin and lipoproteins, for circulation (10 ). Vitamin D metabolism generates a number of different metabolites over a wide dynamic concentration range (2,11 ).…”

Section: Vitamin D Metabolismmentioning

confidence: 99%

Mass Spectrometric Profiling of Vitamin D Metabolites beyond 25-Hydroxyvitamin D

Müller

Volmer

2015

Clinical Chemistry

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BACKGROUND:The frequency of measurements of vitamin D in the human population has significantly increased over the last decade because vitamin D has now been linked to many diseases, in addition to its established role in bone health. Usually, serum 25-hydroxyvitamin D concentrations are measured to assess the vitamin D status of individuals. Unfortunately, many studies investigating links between vitamin D and disease also use only this single metabolite. Intricate correlations with other vitamin D metabolites or dynamic effects of downstream metabolites may therefore be overlooked. Fortunately, powerful LC-MS/MS approaches have recently become available that can simultaneously quantify the concentrations of multiple vitamin D metabolites. These approaches are challenging, however, because of inherent instrumental problems with detection of vitamin D compounds and the low concentrations of the metabolites in biological fluids.CONTENT: This review summarizes recent mass spectrometry assays for the quantitative measurement of multiple vitamin D metabolites and their application in clinical research, with a particular focus on the lowabundance downstream metabolic species generated after the initial hydroxylation to 25-hydroxyvitamin D.

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“…Vitamins D2, D3 and their metabolites are lipophilic and circulate in the blood bound to vitamin D binding protein (DBP) 68 . Once in the liver, vitamins D2 and D3 (from hereto called vitamin D) are metabolized by a microsomal cytochrome P450 mono-oxygenase called 25-vitamin D hydroxylase (gene symbol CYP2R1) into their 25-hydroxy vitamin D (25(OH)D) metabolites (specifically, 25(OH)D2, and 25(OH)D3 or calcidiol).…”

Section: Vitamin Dmentioning

confidence: 99%

Vitamin E and D regulation of allergic asthma immunopathogenesis

Cook‐Mills

Avila

2014

International Immunopharmacology

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Asthma occurs as complex interactions of the environmental and genetics. Clinical studies and animal models of asthma indicate dietary factors such as vitamin E and vitamin D as protective for asthma risk. In this review, we discuss opposing regulatory functions of tocopherol isoforms of vitamin E and regulatory functions of vitamin D in asthma and how the variation in global prevalence of asthma may be explained, at least in part, by these dietary components.

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The Vitamin D Binding Protein DBP

Cited by 32 publications

References 135 publications

Vitamin D-Binding Protein in Healthy Pre- and Postmenopausal Women: Relationship with Estradiol Concentrations

Vitamin D-Binding Protein in Healthy Pre- and Postmenopausal Women: Relationship with Estradiol Concentrations

Mass Spectrometric Profiling of Vitamin D Metabolites beyond 25-Hydroxyvitamin D

Vitamin E and D regulation of allergic asthma immunopathogenesis

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