The vitamin D positive feedback hypothesis of inflammatory bowel diseases

Linneman, Zachary M.; Reis, Caio Luiz Bitencourt; Balaji, Korrayi; Moore, Jeff; Braude, S.

doi:10.1016/j.mehy.2019.04.005

Cited by 3 publications

(1 citation statement)

References 34 publications

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“…A more comprehensive and effective therapeutic strategy is urgently needed. It has been brought out that there might be a positive feedback loop within vitamin D deficiency, inflammation process and IBD, 6 and supplying vitamin D is obvious the most convenient and effective way to break the loop. IBD pathogenesis is associated with genetic susceptibility, immune disorders, intestinal dysbiosis, and environmental risk factors.…”

Section: Introductionmentioning

confidence: 99%

The Role of Vitamin D in Immune System and Inflammatory Bowel Disease

Wu¹,

Liu²,

Deng³

2022

JIR

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Inflammatory bowel disease (IBD) is a nonspecific inflammatory disease that includes ulcerative colitis (UC) and Crohn’s disease (CD). The pathogenesis of IBD is not fully understood but is most reported associated with immune dysregulation, dysbacteriosis, genetic susceptibility, and environmental risk factors. Vitamin D is an essential nutrient for the human body, and it not only regulates bone metabolism but also the immune system, the intestinal microbiota and barrier. Vitamin D insufficiency is common in IBD patients, and the abnormal low levels of vitamin D are highly correlated with disease activity, treatment response, and risk of relapse of IBD. Accumulating evidence supports the protective role of vitamin D in IBD through regulating the adaptive and innate immunity, maintaining the intestinal barrier and balancing the gut microbiota. This report aims to provide a broad overview of the role vitamin D in the immune system, especially in the pathogenesis and treatment of IBD, and its possible role in predicting relapse.

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Section: Introductionmentioning

confidence: 99%

The Role of Vitamin D in Immune System and Inflammatory Bowel Disease

Wu¹,

Liu²,

Deng³

2022

JIR

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Biological sciences underpinning biomechanics

Horwood¹,

Chockalingam²

2023

Clinical Biomechanics in Human Locomotion

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The use of vitamin D for patients with inflammatory bowel diseases

Matias

Lima

Nutels

et al. 2024

International Journal for Vitamin and Nutrition Research

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Abstract. As Vitamin D (VD) plays an essential role in Inflammatory Bowel Diseases, this systematic review aimed to update the participation of this vitamin in the prevention or remission of these diseases. This review has included studies in MEDLINE–PubMed, EMBASE, and Cochrane databases. The authors have followed PRISMA (Preferred Reporting Items for a Systematic Review and Meta-analysis) guidelines. According to the inclusion and exclusion criteria, twenty-two randomized clinical trials were selected. In all, 1,209 patients were included in this systematic review: 1034 received only VD and 175 received VD in combination with calcium. The average doses of VD supplementation were from oral 400 IU daily to 10,000 IU per kilogram of body weight. Single injection of 300,000 IU of VD was also used. Several studies have shown the crucial role that VD plays in the therapeutic approach of IBD due to its effects on the immune system. It effectively decreased inflammatory cytokines such as TNF-α and IFN-γ (p<0.05) and provided a reduction in disease activity assessed through different scores such as Crohn’s Disease Activity Index (CDAI) (p<0.05) and Ulcerative Colitis Disease Activity Index (UCDAI) (p<0.05). Unfortunately, the available clinical trials do not have standardization of doses and routes of administration. Existing meta-analyses are biased because they compare studies using different doses or treatments in combination with different drugs or supplements such as calcium. Even though VD has crucial effects on inflammatory processes, there is still a need for standardized studies to establish how the supplementation should be performed and the doses to be administered.

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The vitamin D positive feedback hypothesis of inflammatory bowel diseases

Cited by 3 publications

References 34 publications

The Role of Vitamin D in Immune System and Inflammatory Bowel Disease

The Role of Vitamin D in Immune System and Inflammatory Bowel Disease

Biological sciences underpinning biomechanics

The use of vitamin D for patients with inflammatory bowel diseases

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