The Vitamin D Receptor Activator Maxacalcitol Provides Cardioprotective Effects in Diabetes Mellitus

Fujii, Hideki; Nakai, Kentaro; Yonekura, Yuriko; Kono, Keiji; Goto, Shunsuke; Hirata, Michinori; Shinohara, Masami; Nishi, Shinichi; Fukagawa, Masafumi

doi:10.1007/s10557-015-6629-y

Cited by 15 publications

(9 citation statements)

References 44 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Many studies have shown that oxidative stress may contribute to the pathogenesis of VC progression in a rat CKD and DM model 28,29 . Our several previous studies also proved that an increase in oxidative stress was associated with the progression of kidney and cardiovascular injury in not only CKD but also DM [16][17][18]30 . In this study, both the CKD and DM groups manifested increased oxidative stress and rats with CKD complicated by DM exhibited increased oxidative stress compared with them.…”

Section: Discussionmentioning

confidence: 61%

Influence of oxidative stress on vascular calcification in the setting of coexisting chronic kidney disease and diabetes mellitus

Watanabe

Fujii

Kono

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

Vascular calcification (VC) is a common complication in patients with chronic kidney disease (CKD). Particularly, CKD patients with diabetes mellitus (DM) develop severe VC. Specific mechanisms of VC remain unclear; this study aimed to investigate them in the context of coexisting CKD and DM, mainly regarding oxidative stress. Sprague Dawley rats were randomly divided into six groups as follows: control rats (Control), 5/6 nephrectomized rats (CKD), streptozotocin-injected rats (DM), 5/6 nephrectomized and streptozotocin-injected rats (CKD + DM), CKD + DM rats treated with insulin (CKD + DM + INS), and CKD + DM rats treated with antioxidant apocynin (CKD + DM + APO). At 18 weeks old, the rats were sacrificed for analysis. Compared to the control, DM and CKD groups, calcification of aortas significantly increased in the CKD + DM group. Oxidative stress and osteoblast differentiation-related markers considerably increased in the CKD + DM group compared with the other groups. Moreover, apocynin considerably reduced oxidative stress, osteoblast differentiation-related markers, and aortic calcification despite high blood glucose levels. Our data indicate that coexisting CKD and DM hasten VC primarily through an increase in oxidative stress; anti-oxidative therapy may prevent the VC progression.

show abstract

Section: Discussionmentioning

confidence: 61%

Influence of oxidative stress on vascular calcification in the setting of coexisting chronic kidney disease and diabetes mellitus

Watanabe

Fujii

Kono

et al. 2020

Sci Rep

Self Cite

View full text Add to dashboard Cite

show abstract

“…2MD is another novel and potent VDRA that has a wider therapeutic margin in the uremic rat model than calcitriol or paricalcitol, and suppresses PTH without hypercalcemia in HD patients [ 163 ]. A recent study showed that maxacalcitol can prevent the development of cardiac damage in DN rats, independent of RAS inhibition [ 164 ]. However, a pooled analysis revealed that there are no differences on the efficacy and safety between paricalcitol and other VDRAs for treating dialysis patients [ 165 ].…”

Section: Therapeutic Effects Of Vdr Activationmentioning

confidence: 99%

Vitamin D Receptor: A Novel Therapeutic Target for Kidney Diseases

Yang

Wang

et al. 2018

CMC

View full text Add to dashboard Cite

Background: Kidney disease is a serious problem that adversely affects human health, but critical knowledge is lacking on how to effectively treat established chronic kidney disease. Mounting evidence from animal and clinical studies has suggested that Vitamin D Re-ceptor (VDR) activation has beneficial effects on various renal diseases.Methods: A structured search of published research literature regarding VDR structure and function, VDR in various renal diseases (e.g., IgA nephropathy, idiopathic nephrotic syndrome, renal cell carcinoma, diabetic nephropathy, lupus nephritis) and therapies targeting VDR was performed for several databases.Result: Included in this study are the results from 177 published research articles. Evidence from these papers indicates that VDR activation is involved in the protection against renal inju-ry in kidney diseases by a variety of mechanisms, including suppression of RAS activation, an-ti-inflammation, inhibiting renal fibrogenesis, restoring mitochondrial function, suppression of autoimmunity and renal cell apoptosis.Conclusion: VDR offers an attractive druggable target for renal diseases. Increasing our under-standing of VDR in the kidney is a fertile area of research and may provide effective weapons in the fight against kidney diseases

show abstract

“…Further, decreased cardiac fibrosis [11] and attenuated cardiac remodeling and dysfunction in polycystic ovarian syndrome [70] with vitamin D supplementation and/or VDR activation suggest the role of vitamin D in treating cardiac fibrosis [71]. Furthermore, the cardioprotective effects of VDR activators and modulators suggest the potential therapeutic role of vitamin D [72–73]. …”

Section: Cardiac Diseasesmentioning

confidence: 99%

Role of Vitamin D in Cardiovascular Diseases

Rai

Agrawal

2017

Endocrinology and Metabolism Clinics of North America

122

View full text Add to dashboard Cite

Vitamin D is critical in mineral homeostasis and skeletal health, and plays regulatory role in non-skeletal tissues. Vitamin D deficiency is associated with chronic inflammatory diseases, including diabetes and obesity both being strong risk factors for cardiovascular diseases (CVD). CVD, including coronary artery disease, myocardial infarction, hypertrophy, cardiomyopathy, cardiac fibrosis, heart failure, aneurysm, peripheral arterial disease, hypertension, and atherosclerosis, are major causes of morbidity and mortality worldwide. The association of these diseases with vitamin D deficiency and improvement with vitamin D supplementation suggest its therapeutic benefit. Here, we critically review the recent findings on the association of vitamin D deficiency and CVD.

show abstract

The Vitamin D Receptor Activator Maxacalcitol Provides Cardioprotective Effects in Diabetes Mellitus

Abstract: Our results suggest that OCT prevents the development of cardiac damage in DM, independent of RAS inhibition.

Cited by 15 publications

References 44 publications

Influence of oxidative stress on vascular calcification in the setting of coexisting chronic kidney disease and diabetes mellitus

Influence of oxidative stress on vascular calcification in the setting of coexisting chronic kidney disease and diabetes mellitus

Vitamin D Receptor: A Novel Therapeutic Target for Kidney Diseases

Role of Vitamin D in Cardiovascular Diseases

Contact Info

Product

Resources

About