The vitamin D receptor polymorphism in the translation initiation codon is a risk factor for insulin resistance in glucose tolerant Caucasians

Chiu, Ken C.; Chuang, Lee‐Ming; Yoon, Carol

doi:10.1186/1471-2350-2-2

Cited by 97 publications

(66 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…If the initiating translation starts from this alternative site (thymine variant), it results in the generation of a longer VDR protein of 427 amino acids (Kostner et al, 2009). The polymorphisms in this area have been studied singly and in combination with other polymorphisms of VDR in a number of malignant and non malignant conditions (Chiu et al, 2001;Malecki et al, 2003;Park et al, 2006;Kadyska et al, 2007;Hubner et al, 2008;Neyestani et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Association of a VDR Gene Polymorphism with Risk of Colorectal Cancer in Kashmir

Rasool

Kadla²,

Khan³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

Roles of the vitamin D receptor in etiology of cancers, including colorectal cancer, have been repeatedly stressed in different parts of the world. A case control study aimed to evaluate the relationship between the two was therefore initiated in Kashmir, known both for its increasing incidence of gastrointestinal cancers and deficiency of micro-nutrients especially vitamin D. The study included a total of 617 subjects (312 colorectal cancer cases and 305 controls), with sampling carried out over a period of 5 years. DNA samples from the blood of the subjects were analyzed for start codon Fok I VDR polymorphism. We obtained a 1.3 fold increased risk among individuals homozygous for f variants as compared to subjects homozygous for F allele (odds ratio OR 1.3, 95%CI, 0.861-1.65). Our study also showed statistically significant results when dwelling and tumor location characteristics were stratified with Fok I polymorphism, all of which suggests a possible role of Fok I polymorphism in the etiology of CRC in Kashmir

show abstract

Section: Introductionmentioning

confidence: 99%

Association of a VDR Gene Polymorphism with Risk of Colorectal Cancer in Kashmir

Rasool

Kadla²,

Khan³

et al. 2013

Asian Pacific Journal of Cancer Prevention

View full text Add to dashboard Cite

show abstract

“…Beside effects on bone metabolism, VDR polymorphisms, in particular BsmI, are associated with cardiovascular risk factors such as increased blood pressure, an unfavorable lipid profile (8,9), increased left ventricular mass in hemodialysis patients (10), and intimal medial thickening of the carotid artery (11). In addition, VDR polymorphisms have been related to an increased risk of myocardial infarction (12) and diabetes mellitus type 2 (13)(14)(15). Moreover, the FokI, GATA, BsmI, and ApaI polymorphisms are related to an increased risk and a worse prognosis of cancer, in particular prostate cancer, breast cancer, and malignant melanoma (16).…”

Section: Introductionmentioning

confidence: 99%

Associations between vitamin D receptor genotypes and mortality in a cohort of older Dutch individuals

Jongh

Lips

Rijs

et al. 2011

European Journal of Endocrinology

View full text Add to dashboard Cite

Context: Vitamin D receptor (VDR) polymorphisms are associated with a variety of diseases, which may translate into an effect on mortality. Objective: To investigate the associations between VDR gene variants and mortality among older people. Design: The analyses were conducted in a population-based, prospective cohort of the Longitudinal Aging Study Amsterdam. Adequate DNA analysis was performed in 923 men and women (R65 years). We aimed to assess the associations between mortality and the VDR polymorphism FokI, three haplotypes of the Cdx2 and GATA polymorphisms, and three haplotypes of the BsmI, ApaI, and TaqI polymorphisms. Results: During the median follow-up of 10.7 years, 480 participants deceased (51%). Homozygosity for the Cdx2-GATA haplotype 1 allele was associated with a 30% higher mortality risk compared to the absence of alleles (hazard ratios (HR) 1.30, 95% confidence intervals (CI) 1.01-1.68). Adjustment for cardiovascular risk factors and 25-hydroxyvitamin D levels did not affect this HR. The number of copies of the Cdx2-GATA haplotype 1 allele was associated, although not significantly, with an increased risk of osteoporotic fractures (0 copiesZreference, HR, 95% CI: 1 copy 2.01, 0.99-4.07 and 2 copies 1.81, 0.87-4.18). After adjustment for osteoporotic fractures, homozygosity for the Cdx2-GATA haplotype 1 allele was no longer associated with higher mortality risk (HR 1.08, 95% CI 0.83-1.41).

show abstract

“…While the exact mechanisms that underlie the multiple effects of vitamin D on different tissues are not currently understood, one unifying factor is the expression of vitamin D receptors (VDRs) in Ͼ30 tissues, including pancreatic islet cells (12). There is some evidence that polymorphisms in the VDR gene may be associated with insulin resistance, insulin secretion, and fasting glucose concentrations (13)(14)(15)(16), suggesting that vitamin D is likely to contribute to glucose metabolism (8). It is also becoming clear that there are physiological interactions between vitamin D, IGF-1, and its binding proteins IGFBP-1 and IGFBP-3 (17,18).…”

mentioning

confidence: 99%

Baseline Serum 25-Hydroxy Vitamin D Is Predictive of Future Glycemic Status and Insulin Resistance

et al. 2008

View full text Add to dashboard Cite

OBJECTIVE-Accumulating epidemiological evidence suggests that hypovitaminosis D may be associated with type 2 diabetes and related metabolic risks. However, prospective data using the biomarker serum 25-hydroxyvitamin D [25(OH)D] are limited and therefore examined in the present study. RESEARCH DESIGN AND METHODS-A total of 524 randomly selected nondiabetic men and women, aged 40 -69 years at baseline, with measurements for serum 25(OH)D and IGF-1 in the population-based Ely Study, had glycemic status (oral glucose tolerance), lipids, insulin, anthropometry, and blood pressure measured and metabolic syndrome risk (metabolic syndrome z score) derived at baseline and at 10 years of follow-up. Baseline 25(OH)D was associated inversely with 10-year risk of hyperglycemia (fasting glucose: ␤ ϭ Ϫ0.0023, P ϭ 0.019; 2-h glucose: ␤ ϭ Ϫ0.0097, P ϭ 0.006), insulin resistance (fasting insulin ␤ ϭ Ϫ0.1467, P ϭ 0.010; homeostasis model assessment of insulin resistance [HOMA-IR]: ␤ ϭ Ϫ0.0059, P ϭ 0.005), and metabolic syndrome z score (␤ ϭ Ϫ0.0016, P ϭ 0.048) after adjustment for age, sex, smoking, BMI, season, and baseline value of each metabolic outcome variable. Associations with 2-h glucose, insulin, and HOMA-IR remained significant after further adjustment for IGF-1, parathyroid hormone, calcium, physical activity, and social class. RESULTS-CONCLUSIONS-This prospective study reports inverse associations between baseline serum 25(OH)D and future glycemia and insulin resistance. These associations are potentially important in understanding the etiology of abnormal glucose metabolism and warrant investigation in larger, specifically designed prospective studies and randomized controlled trials of supplementation. Diabetes 57:2619-2625, 2008 T hough the most well-known role of vitamin D is the regulation of calcium absorption and bone metabolism, it is becoming clear that this hormone has pleiotropic effects with possible roles in the pathogenesis of cancer (1), cardiovascular disease (2), multiple sclerosis (3), and type 1 diabetes (4). Recent epidemiological evidence (5-9) also points to a potential association of vitamin D insufficiency with adverse metabolic risk, including that for type 2 diabetes (10,11). While the exact mechanisms that underlie the multiple effects of vitamin D on different tissues are not currently understood, one unifying factor is the expression of vitamin D receptors (VDRs) in Ͼ30 tissues, including pancreatic islet cells (12). There is some evidence that polymorphisms in the VDR gene may be associated with insulin resistance, insulin secretion, and fasting glucose concentrations

show abstract

The vitamin D receptor polymorphism in the translation initiation codon is a risk factor for insulin resistance in glucose tolerant Caucasians

Cited by 97 publications

References 39 publications

Association of a VDR Gene Polymorphism with Risk of Colorectal Cancer in Kashmir

Association of a VDR Gene Polymorphism with Risk of Colorectal Cancer in Kashmir

Associations between vitamin D receptor genotypes and mortality in a cohort of older Dutch individuals

Baseline Serum 25-Hydroxy Vitamin D Is Predictive of Future Glycemic Status and Insulin Resistance

Contact Info

Product

Resources

About