2003
DOI: 10.1016/s0014-2999(03)01275-5
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The Vogel conflict test: procedural aspects, γ-aminobutyric acid, glutamate and monoamines

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Cited by 140 publications
(112 citation statements)
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“…The ability of a drug to increase punished responding in ''conflict'' procedures is highly predictive of an antianxiety effect in humans (21,22,29). Ocinaplon produced a dose-related increase in punished responding in a ''thirsty rat'' conflict procedure (21) with a potency and efficacy comparable to the prototypic benzodiazepine, diazepam (Fig.…”
Section: Preclinical Studies In Rodents Andmentioning
confidence: 99%
“…The ability of a drug to increase punished responding in ''conflict'' procedures is highly predictive of an antianxiety effect in humans (21,22,29). Ocinaplon produced a dose-related increase in punished responding in a ''thirsty rat'' conflict procedure (21) with a potency and efficacy comparable to the prototypic benzodiazepine, diazepam (Fig.…”
Section: Preclinical Studies In Rodents Andmentioning
confidence: 99%
“…Results with a series of compounds that are structurally related to pregabalin and gabapentin suggest that high-affinity binding to ␣ 2 ␦ accurately predicts anxiolyticlike activity in the rat Vogel conflict model, one of the most predictive assays for identifying compounds with anxiolytic-like properties (Vogel et al, 1971;Millan and Brocco, 2003;Belliotti et al, 2005). Gabapentin and pregabalin have also been reported to produce anxiolytic-like activity in the elevated plus maze, Geller conflict test, and an animal model for post-traumatic stress disorder (Field et al, 2001;Zohar et al, 2008).…”
Section: Introductionmentioning
confidence: 99%
“…The response differs in various paradigms; this could be an operant response, such as lever pressing for food or pressing a button to see art, or a consummatory response, such as drinking water. While the subjects are performing this response, either an aversive stimulus (such as a shock) or a stimulus which was previously classically conditioned to an aversive stimulus is presented, which normally causes a decrease in responding for the positive reinforcer (originally described in rats in Gellert and Seifter 1960; more recent data in Barros and Tomaz 2002;Fuchs and Flügge 2006;Millan and Brocco 2003). This decrease in responding is sensitive to anxiolytic as well as some antidepressant drugs in rodents (Borsini et al 2002) and non-human primates (Hanson et al 1967;Sepinwall et al 1978).…”
Section: Translational Research With Mglur Binding: Development Of a mentioning
confidence: 99%