2005
DOI: 10.1073/pnas.0501770102
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The voltage-gated potassium channel Kv1.3 is highly expressed on inflammatory infiltrates in multiple sclerosis brain

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Cited by 172 publications
(176 citation statements)
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“…21,49 During myelination and demyelination, Kv1.4 is particularly expressed on oligodendroglial cells. Kv1.4 expression is not found on immune cells, although the expression of the related channels Kv1.3 and Kv1.5 may be involved in T-cell activation and dendritic cell function in EAE and MS. 29,30,50,51 During oligodendroglial development in vitro, there is a clear coexpression of Kv1.4 with AN2 in cells, which at a certain stage are also CNPase-positive. During MOG-EAE in vivo, Kv1.4 is only found on very few AN2-positive cells, which are also CNPase-positive.…”
Section: Discussionmentioning
confidence: 99%
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“…21,49 During myelination and demyelination, Kv1.4 is particularly expressed on oligodendroglial cells. Kv1.4 expression is not found on immune cells, although the expression of the related channels Kv1.3 and Kv1.5 may be involved in T-cell activation and dendritic cell function in EAE and MS. 29,30,50,51 During oligodendroglial development in vitro, there is a clear coexpression of Kv1.4 with AN2 in cells, which at a certain stage are also CNPase-positive. During MOG-EAE in vivo, Kv1.4 is only found on very few AN2-positive cells, which are also CNPase-positive.…”
Section: Discussionmentioning
confidence: 99%
“…26 In particular, the Kv1.4 subunit has been associated with proliferation in pathological states such as spinal cord injury, 27,28 whereas Kv1.3 and 1.5 are expressed in T cells and dendritic cells during autoimmune demyelination. 29,30 Here, we investigate the expression of Kv1.4 potassium channels in myelin oligodendrocyte glycoprotein peptide )-induced experimental autoimmune encephalomyelitis, an experimental model mimicking aspects of MS, in particular myelin damage and loss of OLs. 31 Our data reveal a re-expression of this developmentally restricted potassium channel in proliferating premyelinating oligodendroglial cells after autoimmune demyelination and suggest a role for Kv1.4 in oligodendroglial proliferation and remyelination.…”
mentioning
confidence: 99%
“…Electrophysiological experiments on slices15 or acutely isolated microglia16 have further demonstrated Kv1.3 currents on activated microglia following MCAO. In humans, strong Kv1.3 staining has been reported on microglia in the frontal cortex of patients with Alzheimer's disease17 and on CD68 + cells in multiple sclerosis brain lesions 18. Using cultured neonatal mouse microglia, our group recently demonstrated that Kv1.3 expression increases following stimulation with the M1‐polarizing stimuli LPS or LPS plus IFN‐ γ , while IL‐4 stimulation induced a down‐regulation of Kv1.3 and an increase in currents for the inward‐rectifier K + channel Kir2.1,19 suggesting that Kv1.3 blockers might be able to preferentially target detrimental proinflammatory M1 microglia functions.…”
Section: Introductionmentioning
confidence: 99%
“…Brain immunohistochemical staining was performed as previously described (Rus et al, 2005) using monoclonal and polyclonal antibodies listed in Table 1. The air-dried cryostat sections (4-6μm) were fixed for 10 min in acetone containing 0.3% H 2 O 2 to remove endogenous peroxidase.…”
Section: Immunohistochemistrymentioning
confidence: 99%