2015
DOI: 10.1016/j.bbr.2015.06.022
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The voltage-gated sodium channel activator veratrine induces anxiogenic-like behaviors in rats

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Cited by 7 publications
(6 citation statements)
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“…6). Veratrine is also a voltage‐gated sodium channel activator, 43 and it was already confirmed that co‐application of potassium channel blockers with pyrethroids could synergize the mosquitocidal activities of A. gambiae 44 . Hence, multi‐target drugs could be developed to act on sodium and potassium channels at the same time to enhance the disturbance of action potential conduction.…”
Section: Discussionmentioning
confidence: 95%
“…6). Veratrine is also a voltage‐gated sodium channel activator, 43 and it was already confirmed that co‐application of potassium channel blockers with pyrethroids could synergize the mosquitocidal activities of A. gambiae 44 . Hence, multi‐target drugs could be developed to act on sodium and potassium channels at the same time to enhance the disturbance of action potential conduction.…”
Section: Discussionmentioning
confidence: 95%
“…Interestingly, calcium channel antagonists showed inhibition of OCD behaviours in OCD mouse models and had anxiolytic effects (Bandelow, 2008;Egashira et al, 2008), while sodium channel activators have been shown to induce anxiety-and OCD-like behaviours in rats (Saitoh et al, 2015). These studies support a potential shared molecular pathophysiology between ion channel disorders and OCD-related phenotypes.…”
Section: Prevalence Of Treatable Genetic Disorder Variants Within the Study Cohortmentioning
confidence: 94%
“…Data were included if the publication reported lighting measures, whereas if the publication did not, it was excluded (i.e., this also excluded any other work that previously cited other work). The number of remaining articles that met the criteria for these animal behavioral testing purposes were: the Light/Dark Box Test [ n = 98 (Banaskowski et al, 2015 ; Bentea et al, 2015 ; Bertolus et al, 2015 ; Brown et al, 2015 ; Chao et al, 2015 ; Colla et al, 2015 ; Kalouda and Pitsikas, 2015 ; Lee K. M. et al, 2015 ; Lee et al, 2017 ; Liu et al, 2015 ; Livingston-Thomas et al, 2015 ; Pereda et al, 2015 ; Quines et al, 2015 ; Saitoh et al, 2015 ; Sauce et al, 2015 ; Skupio et al, 2015 ; Thompson et al, 2015 ; Tothova et al, 2015 ; Yu et al, 2015 ; Zhan, 2015 ; Zhang C. et al, 2015 ; Zhang et al, 2016 ; Acevedo et al, 2016 ; Christensen et al, 2016 ; Daniel and Hughes, 2016 ; Diaz et al, 2016 ; Farajdokht et al, 2016 ; Fedotova et al, 2016 ; Fernandez et al, 2016 ; Hicks J. A. et al, 2016 ; Hughes and Hancock, 2016 ; Labots et al, 2016 ; Li J. et al, 2016 ; Miranda-Morales and Pautassi, 2016 ; Mlyniec et al, 2016 ; Rojas et al, 2016 ; Salari et al, 2016 ; Scheinert et al, 2016 ; Socala and Wlaz, 2016 ; Stohn et al, 2016 ; Vogt et al, 2016 ; Abdellatif et al, 2017 ; Alkhlaif et al, 2017 ; Bahi, 2017b ; Benoit et al, 2017 ; Borbely et al, 2017 ; Chandra Sekhar et al, 2017 ; Djordjevic et al, 2017 ; Domonkos et al, 2017 ; Khalil and Fendt, 2017 ; Makinson et al, …”
Section: Methodsmentioning
confidence: 99%