The Volume of Blood Flow Per Minute Through the Lungs Following Collapse of One Lung by Occlusion of Its Bronchus

Moore, Richmond L.

doi:10.1001/archsurg.1931.01160020048003

Cited by 38 publications

(4 citation statements)

References 20 publications

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“…With regard to the mechanism underlying an adaptation of this kind, mechanical factors have been suggested and their action has been studied in experiments with artificial respiration and perfusion [Tigerstedt, 1903;Wiggers, 1921;de Burgh Daly, 1930]. The decrease in lung circulation resulting from collapse of the lungs and from resorption atelectasis has been demonstrated by Moore [1931], Torning [1933], Dirken, Kraan, Oostinga and Woudstra [1942], and others. In these circumstances mainly mechanical factors are involved.…”

Section: Resultsmentioning

confidence: 99%

The Adaptation of the Lung Circulation to the Ventilation

Dirken

Heemstra

1948

Exp Physiol

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In normal circumstances 55 per cent. of the total blood supply to the lungs of the rabbit is directed to the right and 45 per cent. to the left lung. On lowering the alveolar oxygen tension in one lung its blood circulation may be gradually reduced to less than half of the original value. while the circulation of the other lung shows a corresponding increase. A drop in the alveolar oxygen percentage of 2 to 2·5 per cent. in one lung may reduce the blood‐flow by 15 per cent. of the original value. The significance of these results with reference to an adaptation of the circulation to the unequal ventilation of the lungs is discussed.

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Section: Resultsmentioning

confidence: 99%

The Adaptation of the Lung Circulation to the Ventilation

Dirken

Heemstra

1948

Exp Physiol

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“…No such change can be seen when the block was applied at the end of expiration. In a study of the blood flow through a lung collapsed by occlusion of its bronchus, by the same author (9), the depth of breathing of the opposite lung was consistently found to be increased and the degree of increase was most marked after right-sided collapse. The effect on respiratory rate was variable.…”

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confidence: 96%

The Effect on Respiration of the Occlusion of a Bronchus in Man During Bronchospirometry

Pump¹

1954

J. Clin. Invest.

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During the course of a routine bronchospirometry on a patient suffering from pulmonary tubercutlosis, the observation was made that when the catheter leading to one lung was clamped at the end of a normal expiration there was an immediate increase in tidal volume, in the functional residual capacity and in the respiratory rate in the other lung. This phenomenon persisted until the block was removed, whereupon these three factors returned to normal within three breaths.Experiments in which a bronchus was occluded have been reported by many investigators (1-7). According to Andrus (2) ligation of a bronchus in dogs under ether anesthesia induced a 20 per cent increase in minute ventilation and the respiratory rate immediately after operation before the anesthetic had lost its effect. Twenty-four hours later the minute ventilation had increased by 32 per cent and the respiratory rate by 30 per cent (2). Churchill and Agassiz (3) found that occlusion of either the right pulmonary artery or of the right bronchus in animals caused almost identical increases in the minute ventilation. Clamping of the bronchus was attended by a high degree of respiratory difficulty and could not be maintained for any period of time. The authors felt that the surgery necessary to prepare the specimen may have profoundly disturbed the mechanical conditions of respiration. In four experiments on dogs, anesthetized with barbital sodium, Moore (8) observed that blocking the right bronchus at the end of expiration produced a relatively deep inspiration as the next movement of the lung and the respiratory rate immediately slowed. After five minutes the respiratory rate accelerated to 34 per minute, 13 per minute above the control level. When the right bronchus was blocked at the end of inspiration, the next movement of the lung was a relatively deep expiration and the respiratory rate immediately slowed but within three minutes accelerated to 38 per minute. Although no mention is made of a change in the functional residual capacity, the graph illustrating the respiratory movements before and after the block, shows a decrease when the right bronchus was blocked in inspiration. No such change can be seen when the block was applied at the end of expiration. In a study of the blood flow through a lung collapsed by occlusion of its bronchus, by the same author (9), the depth of breathing of the opposite lung was consistently found to be increased and the degree of increase was most marked after right-sided collapse. The effect on respiratory rate was variable. The minute ventilation was conspicuously increased in all of the experiments. From the data presented, it seems that the observations were made when the blocked lung was totally collapsed.In man twd methods of blocking a lung have been used. The first consists of clamping the tube leading to one of the lumina of the double bronchoscope and the other of feeding pure nitrogen to one lung. The effect of blocking one lung in three normal subjects was studied with respect to the effect upon the ot...

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“…It has been demonstrated in studies on dogs (Moore, 1931;Berggren, 1942) that prolonged blockade of one of the main bronchi causes a reduction to 50% of the perfusion in the blocked lung. Bjork (1953) carried out an angiographic study of TB patients with prolonged atelectasis and found that a considerable amount of blood still passed through the atelectatic lung in the acute stage.…”

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confidence: 99%

Ventilation and Perfusion of the Lungs Before and During Blockade of One of the Main Bronchi

Svendsen

Fabricius

Juhl

et al. 1974

Scandinavian Journal of Thoracic and Cardiovascular Surgery

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An attempt has been made to evaluate the magnitude of and changes in the right-left shunt following 40 minutes' blockade of one of the main bronchi in 6 anaesthetized patients, of whom 3 had the right and 3 the left bronchus blocked. Xenon'" was used together with a simple transportable apparatus employing four collimators on the anterior of the thorax. Despite verified blockade (bronchoscopy and stethoscopy), the study showed an activity corresponding to a ventilation of approximately one-third of the initial values. It was not possible to demonstrate any fall in the perfusion on the blocked side following blockade of the left main bronchus, whereas blockade of the right main bronchus produced a calculated fall to two-thirds of the initial perfusion. The blockade caused a fall in PaO, in all the patients, which was inpendent upon the side blocked and of a magnitude that corresponded to the perfusion measured after blockade of the right main bronchus.

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The Volume of Blood Flow Per Minute Through the Lungs Following Collapse of One Lung by Occlusion of Its Bronchus

Cited by 38 publications

References 20 publications

The Adaptation of the Lung Circulation to the Ventilation

The Adaptation of the Lung Circulation to the Ventilation

The Effect on Respiration of the Occlusion of a Bronchus in Man During Bronchospirometry

Ventilation and Perfusion of the Lungs Before and During Blockade of One of the Main Bronchi

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