2019
DOI: 10.1002/cam4.2601
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The volume of 99mTc sulfur colloid SPET‐defined active bone marrow can predict grade 3 or higher acute hematologic toxicity in locally advanced cervical cancer patients who receive chemoradiotherapy

Abstract: BackgroundThe purpose of the current study was to evaluate whether radiation dose‐volume metrics to technetium‐99m (99mTc) sulfur colloid single‐photon emission tomography (SPET)‐defined active bone marrow (ABM) subregions can more accurately predict acute hematologic toxicity in locally advanced cervical cancer patients who receive chemoradiotherapy than conventional dosimetric parameters.Methods and materialsThirty‐nine patients with stage IB2‐III cervical cancer who underwent 99mTc sulfur colloid SPET imagi… Show more

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Cited by 18 publications
(42 citation statements)
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“…Similar mean PB-volumes (1553cm 3 (range 1117-1920cm 3 ) [39] vs 1433cm3 (range 901-1920cm 3 ) [37]) and ABM-volumes (1227cm 3 (range 793-1671cm 3 ) [39] vs 1098cm 3 (range 387-1671cm 3 ) [37]) were reported in the articles applying 18F-FDG-PET-CT. The article focusing on Tc-99m sulfur colloid SPET showed lower volumes as the mean PB-volume was 954 (156) cm 3 and the mean ABM-volume was 355 (173) cm 3 , which might be due to the different imaging modality used [40]. All three authors agreed that patients with a low pretreatment ABMvolume were more likely to develop HT3+ than patients with a larger ABM-volume before irradiation.…”
Section: Active Bone Marrow (Abm)mentioning
confidence: 94%
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“…Similar mean PB-volumes (1553cm 3 (range 1117-1920cm 3 ) [39] vs 1433cm3 (range 901-1920cm 3 ) [37]) and ABM-volumes (1227cm 3 (range 793-1671cm 3 ) [39] vs 1098cm 3 (range 387-1671cm 3 ) [37]) were reported in the articles applying 18F-FDG-PET-CT. The article focusing on Tc-99m sulfur colloid SPET showed lower volumes as the mean PB-volume was 954 (156) cm 3 and the mean ABM-volume was 355 (173) cm 3 , which might be due to the different imaging modality used [40]. All three authors agreed that patients with a low pretreatment ABMvolume were more likely to develop HT3+ than patients with a larger ABM-volume before irradiation.…”
Section: Active Bone Marrow (Abm)mentioning
confidence: 94%
“…Delineation method specified Six of the included studies examined the correlation between radiation dose to the active bone marrow (ABM) and the development of HT [21,[36][37][38][39][40]. 18F-FDG-PET-CT was used by five studies and the technetium-99m (Tc-99m) sulfur colloid SPET was used by one study to quantify standardized uptake values (SUVs).…”
Section: Active Bone Marrow (Abm)mentioning
confidence: 99%
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