1967
DOI: 10.1007/bf02142244
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The waking action of histamine

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Cited by 29 publications
(15 citation statements)
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“…The maximum histamine level is about double that of the minimum values found during decreased motor activity and sleep. Recently, Monnier, Fallert & Bhattacharya (1967) reported that the intravenous infusion of histamine in the rabbit sharply decreased the delta activity of the cortex, i.e. high voltage 0-5-3-5 c/s sleep spindles, and increased the desynchronization of the e.e.g.…”
Section: Discussionmentioning
confidence: 99%
“…The maximum histamine level is about double that of the minimum values found during decreased motor activity and sleep. Recently, Monnier, Fallert & Bhattacharya (1967) reported that the intravenous infusion of histamine in the rabbit sharply decreased the delta activity of the cortex, i.e. high voltage 0-5-3-5 c/s sleep spindles, and increased the desynchronization of the e.e.g.…”
Section: Discussionmentioning
confidence: 99%
“…H1R, H2R, and H3R are abundantly expressed in the brain; all of them display constitutive activity. The sedative effects of antihistamines (H1 antagonists) have prompted early suggestions of histamine as a waking substance [74]. Neuronal excitation is achieved by activation of H1R, Gq/11 proteins, and phospholipase C, the formation of the two second messengers DAG and IP3, as well as intracellular Ca 2+ release, opening of cation channels, activating an electrogenic Na-Ca exchanger (NCX), and formation of NO and cyclic GMP.…”
Section: Targets Of Histamine Neuronsmentioning
confidence: 99%
“…The sedation caused by classical antihistamines (H1 receptor antagonists) has long been known as an undesirable side effect in the treatment of allergy [23]. Only after histamine was recognized as a transmitter in the brain [33,57,84,92,110,139], a block of histamine receptors was made responsible for the drowsiness caused by antihistamines including many drugs used in the treatment of neuropsychiatric diseases [74].…”
mentioning
confidence: 99%
“…This propelled histamine into the central nervous system (CNS) and histamine was termed as a “waking substance” (6). While research on other monoamines (norepinephrine and serotonin) in the CNS thrived during the first half of 20 th century, research on histamine lagged behind, mainly because fluorescent histochemistry that revealed the presence of norepinephrinergic and serotonergic systems in the brain was unable to localize the histaminergic system in the CNS (7*), It was only after immunohistochemical studies revealed the presence of histaminergic system in the brain that histamine was awarded the coveted status of the “neurotransmitter” (8*;9*).…”
Section: History Of Histaminementioning
confidence: 99%