The Wanderings of Gut-Derived IgA Plasma Cells: Impact on Systemic Immune Responses

Keppler, Selina J.; Goess, Marie Christine; Heinze, Julia M.

doi:10.3389/fimmu.2021.670290

Cited by 20 publications

(16 citation statements)

References 82 publications

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“…Terminally differentiated plasma cells reside along the dural sinuses of mice and humans 32,91 . Interestingly, most of these plasma cells are IgA‐producers, 91 which are crucial for protection of other peripheral barrier surfaces and mucosal tissues such as the gut 98 . A recent imaging study demonstrated that IgA plasma cells residing along the dural venous sinuses increased with age and were originally educated in the gut by the microbiome 91 .…”

Section: Cns Immune Surveillance and Maintenance Of Homeostasismentioning

confidence: 99%

“…32,91 Interestingly, most of these plasma cells are IgA-producers, 91 which are crucial for protection of other peripheral barrier surfaces and mucosal tissues such as the gut. 98 A recent imaging study demonstrated that IgA plasma cells residing along the dural venous sinuses increased with age and were originally educated in the gut by the microbiome. 91 These cells were shown to protect the underlying brain parenchyma from blood-borne pathogens.…”

Section: Within This Niche T Cells Can Survey Antigen-presenting Cell...mentioning

confidence: 99%

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Immune dynamics in the CNS and its barriers during homeostasis and disease*

Buckley

McGavern

2022

Immunological Reviews

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The central nervous system (CNS) has historically been viewed as an immunologically privileged site, but recent studies have uncovered a vast landscape of immune cells that reside primarily along its borders. While microglia are largely responsible for surveying the parenchyma, CNS barrier sites are inhabited by a plethora of different innate and adaptive immune cells that participate in everything from the defense against microbes to the maintenance of neural function. Static and dynamic imaging studies have revolutionized the field of neuroimmunology by providing detailed maps of CNS immune cells as well as information about how these cells move, organize, and interact during steady-state and inflammatory conditions. These studies have also redefined our understanding of neural-immune interactions at a cellular level and reshaped our conceptual view of immune privilege in this specialized compartment. This review will focus on insights gained using imaging techniques in the field of neuroimmunology, with an emphasis on anatomy and CNS immune dynamics during homeostasis, infectious diseases, injuries, and aging.

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Section: Cns Immune Surveillance and Maintenance Of Homeostasismentioning

confidence: 99%

Section: Within This Niche T Cells Can Survey Antigen-presenting Cell...mentioning

confidence: 99%

Immune dynamics in the CNS and its barriers during homeostasis and disease*

Buckley

McGavern

2022

Immunological Reviews

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“…Protein A elicits a higher affinity for human IgG (IgG1 and IgG2) than IgM and IgA and interacts strongly with IgG2a and IgG3 compared to IgG1 in mice ( Rodrigo et al, 2015 ). However, it has been reported that colonization of commensal bacteria in humans primarily triggered the production of IgA by B cells ( Keppler et al, 2021 ). Although the binding of protein A with subclasses of antibodies in mice is not yet determined, replacement of protein A with protein L ( Rodrigo et al, 2015 ), a Peptostreptococcus magnus protein with a high affinity to representatives of most antibody classes, may be able to broadly capture different classes of antibodies including IgA in mice.…”

Section: Discussionmentioning

confidence: 99%

Circulating Antibodies to Skin Bacteria Detected by Serological Lateral Flow Immunoassays Differentially Correlated With Bacterial Abundance

Huang¹,

Lee²,

Moochhala³

2021

Front. Microbiol.

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The serological lateral flow immunoassay (LFIA) was used to detect circulating antibodies to skin bacteria. Next-generation sequencing analysis of the skin microbiome revealed a high relative abundance of Cutibacterium acnes but low abundance of Staphylococcus aureus and Corynebacterium aurimucosum on human facial samples. Yet, results from both LFIA and antibody titer quantification in 96-well microplates illustrated antibody titers that were not correspondent, and instead negatively correlated, to their respective abundance with human blood containing higher concentrations of antibodies to both S. aureus and C. aurimucosum than C. acnes. Acne vulgaris develops several unique microbial and cellular features, but its correlation with circulating antibodies to bacteria in the pilosebaceous unit remains unknown. Results here revealed that antibodies to C. acnes and S. aureus were approximately 3-fold higher and 1.5-fold lower, respectively, in acne patients than in healthy subjects. Although the results can be further validated by larger sample sizes, the proof-of-concept study demonstrates a newfound discrepancy between the abundance of skin bacteria and amounts of their corresponding antibodies. And in light of acne-correlated amplified titers of specific anticommensal antibodies, we highlight that profiling these antibodies in the pilosebaceous unit by LFIAs may provide a unique signature for monitoring acne vulgaris.

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“…Antibodies play a vital role in homeostasis and protective immunity at mucosal sites, as well as during systemic infections 46 , 47 , and can be divided into five isotypes, which operate in distinct places and have distinct effector functions 48 . Antibody effector functions have classically been studied in the context of pathogenic infections 49 .…”

Section: Antibody-mediated Immunity Against C Albicansmentioning

confidence: 99%

Immunosurveillance of Candida albicans commensalism by the adaptive immune system

Swidergall

LeibundGut‐Landmann

2022

Mucosal Immunology

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The fungal microbiota (mycobiota) is an integral part of the microbial community colonizing the body surfaces and is involved in many key aspects of human physiology, while an imbalance of the fungal communities, termed fungal dysbiosis, has been described in pathologies ranging from infections to inflammatory bowel disease. Commensal organisms, such as the fungus Candida albicans, induce antigen-specific immune responses that maintain immune homeostasis. Adaptive immune mechanisms are vital in this process, while deficiencies in adaptive immunity are linked to fungal infections. We start to understand the mechanisms by which a shift in mycobiota composition, in particular in C. albicans abundance, is linked to immunopathological conditions. This review discusses the mechanisms that ensure continuous immunosurveillance of C. albicans during mucosal colonization, how these protective adaptive immune responses can also promote immunopathology, and highlight therapeutic advances against C. albicans-associated disease.

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The Wanderings of Gut-Derived IgA Plasma Cells: Impact on Systemic Immune Responses

Cited by 20 publications

References 82 publications

Immune dynamics in the CNS and its barriers during homeostasis and disease*

Immune dynamics in the CNS and its barriers during homeostasis and disease*

Circulating Antibodies to Skin Bacteria Detected by Serological Lateral Flow Immunoassays Differentially Correlated With Bacterial Abundance

Immunosurveillance of Candida albicans commensalism by the adaptive immune system

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