Water resources, the social economy, and the ecological environment are interrelated and interacting complex systems, and the relationship among them affects the sustainable development of a region. To explore the interactive relationship and driving factors between water resources, the social economy, and the ecological environment, the Yellow River Golden Triangle region is taken as the research object in this paper. By constructing a coupling-coordination evaluation index system of water resources, the social economy, and the ecological environment system, the coupling-coordination development of this region from 2011 to 2021 is studied using the coupling-coordination degree model, and the influencing factors of coupling-coordination development are identified by gray relational analysis. The results show that from 2011 to 2021, the comprehensive evaluation index of the water resources, social economy, and ecological environment in the Yellow River Golden Triangle region shows a trend of steady development followed by a gradual increase. The water-resources subsystem restricts the development of the coupling system. The coupling-coordination degree increased from a barely coordinated stage in 2011 to a well-coordinated stage in 2021. The social economy subsystem and water-resources subsystem are the main factors affecting the coordinated development of the coupling system.