The Weak Mutagenicity of CDA to Strain TA98 of Salmonella typhimurium

Ashby, John; Callander, R.D.; Paton, David M.

doi:10.1007/978-1-349-07901-8_23

Cited by 1 publication

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“…These compounds were tested in a wide range of genotoxicity assays, including the Ames test. CDA is a very weak mutagen in strain TA98 with rat liver S9 activation, yielding a slight increase in revertant yield at about 0.1–0.4 mg per plate, and is negative in the absence of S9 (Ashby et al, ). The organizers of the study noted that “lack of resources prevented the [rodent carcinogenesis] bioassay of CDA in this study” (Parry et al, ).…”

Section: Discussionmentioning

confidence: 99%

Structure–activity investigation of the potentiating effect of cyano substitution on nitroaniline mutagenicity in the ames test

Josephy

Dhanoa

Elzawy

et al. 2017

Environ and Mol Mutagen

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2,6-Dicyano-4-nitroaniline and 2-cyano-4-nitroaniline (CNNA; 2-amino-5-nitrobenzonitrile) are potent mutagens in the Ames test, even though unsubstituted nitroanilines (NAs) are no more than weak mutagens. These compounds are putative reduction products of many commercial azo dyes, including Disperse Blue 165, Disperse Blue 337, Disperse Red 73, Disperse Red 82, Disperse Violet 33, and Disperse Violet 63. We have examined the mutagenicity in strains TA98 and YG1024 of a series of commercially-available isomers of CNNA, and some related compounds, to probe the relationship between structure and genotoxic activity in this class of compounds. The potentiating effect of the cyano substituent is seen in many cases; e.g. 2-amino-4-nitrobenzonitrile is a much more potent mutagen than 3-NA. 2,4-Dinitrobenzonitrile is also highly mutagenic. Possible mechanisms for the "cyano effect" are considered, with respect to the likely structures of cyanonitroaniline-DNA adducts and the roles of the enzymes (nitroreductase and acetyl CoA:arylamine N-acetyltransferase) believed to be involved in the activation of nitroaromatic compounds. Environ. Mol. Mutagen. 59:114-122, 2018. © 2017 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 99%