The Wegener's granulomatosis quantitative trait locus on chromosome 6p21.3 as characterised by tagSNP genotyping

Heckmann, Michael; Holle, Julia; Arning, Larissa; Knaup, Silvia; Hellmich, Bernhard; Nothnagel, Michael; Jagiello, Peter; Gross, Wolfgang L.; Epplen, Jörg T.; Wieczorek, Stefan

doi:10.1136/ard.2007.077693

Cited by 85 publications

(71 citation statements)

References 33 publications

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“…A number of studies have shown an association of HLA genes, including both class I and class II, with the disease susceptibility of AAV (8)(9)(10)(11)(12)(13)(14). There are five loci of MHC class II genes in HLA, including HLA-DR, HLA-DP, HLA-DQ HLA-DO, and HLA-DM.…”

Section: Introductionmentioning

confidence: 99%

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Association of HLA Genes with Clinical Outcomes of ANCA-Associated Vasculitis

Chang

Luo

Zhou

et al. 2012

Clinical Journal of the American Society of Nephrology

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SummaryBackground and objectives The HLA system plays a central role in the distinction between self antigens and non-self antigens. This study aimed to investigate the association between HLA genes and the outcomes of patients with ANCA-associated vasculitis (AAV).Design, setting, participants, & measurements This study recruited 152 consecutive Chinese patients with AAV. The predictive value of the HLA alleles for renal outcome, response to treatment, and all-cause mortality were analyzed. ResultsThe proportion of patients with treatment failure was significantly higher in DRB1*0405-positive patients than in DRB1*0405-negative patients (41.7% versus 12.9%; P=0.008; corrected P=0.02). After adjusting for the other potential predictors, DRB1*0405 was still an independent predictor for the poor response to treatment (hazard ratio [HR], 5.91; 95% confidence interval [95% CI], 1.23-28.52; P=0.03). Renal survival was significantly worse in patients with DRB1*0405 than those without DRB1*0405 (P,0.001; corrected P,0.001). After adjusting for the other potential predictors, DRB1*0405 was still an independent predictor for ESRD (HR, 5.50; 95% CI, 2.18-13.88; P,0.001). The probability of all-cause mortality in patients with DPB1*0402 was significantly higher than those without DPB1*0402 (P=0.02; corrected P=0.04). After adjusting for the other potential predictors, DPB1*0402 was still an independent predictor for all-cause mortality (HR, 2.52; 95% CI, 1.21-5.28; P=0.01).Conclusions In AAV patients, DRB1*0405 might be an independent risk factor for the poor response to treatment and the deterioration of renal function, whereas DPB1*0402 might be an independent risk factor for all-cause mortality.

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Section: Introductionmentioning

confidence: 99%

“…Among the genetic factors, HLA genes are considered a set of suspected genes in the development of AAV (8)(9)(10)(11)(12)(13)(14). A number of studies have shown an association of HLA genes, including both class I and class II, with the disease susceptibility of AAV (8)(9)(10)(11)(12)(13)(14).…”

Section: Introductionmentioning

confidence: 99%

Association of HLA Genes with Clinical Outcomes of ANCA-Associated Vasculitis

Chang

Luo

Zhou

et al. 2012

Clinical Journal of the American Society of Nephrology

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“…A major genomic risk locus for WG has been identified on chromosome 6p21.3 including the HLA-DPB1 gene. 6,7,8 Another HLA locus, HLA-DR, has also been linked to WG susceptibility. 9,10 Other genetic risk factors for WG comprise a polymorphism in PTPN22, 11 which has been identified as a risk factor in different (auto)-immune disorders, and variations in the a1-antitrypsin gene.…”

Section: Introductionmentioning

confidence: 99%

Novel association of the CD226 (DNAM-1) Gly307Ser polymorphism in Wegener's granulomatosis and confirmation for multiple sclerosis in German patients

et al. 2009

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“…Research is being carried out to confirm this association, for instance, to confirm the possible relation between WG and a region on chromosome 6p21.3 (11) , although further investigation is needed. Indeed, this autoimmune disease is genetically associated with the class II region of the major www.intechopen.com histocompatibility complex (MHC), such as HLA-DPB1*0401 allele (12,13) . Similarly to other autoimmune diseases, the functional polymorphism, 620W, in the intracellular tyrosine phosphatase gene PTPN 22, is a predisposing factor for WG in the presence of ANCA.…”

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confidence: 99%