Weight self-stigma is conceptualized as a multidimensional concept involving experiences of shame, self-devaluation and the perception of being discriminated against in social situations due to one's weight. It has been associated with experiential avoidance, unhealthy eating behaviours, binge eating and diminish quality-of-life (QoL). The current study aims to explore the mediation effect of weight-related experiential avoidance on the relationship between weight self-stigma and obesity-related QoL in women with and without binge eating (BE).The sample comprised 282 women with overweight or obesity, from which 100 presented BE symptoms. Sample's mean age was 44.24 (SD = 11.30), with a mean BMI of 31.40 (SD = 4.53). Participants completed a set of self-reported measures regarding BE symptoms, weight self-stigma, weight-related experiential avoidance and QoL.Results from path analysis supported the mediation of weight-related experiential avoidance on the relationship between weight self-stigma and QoL, even when controlling for BMI. The model accounted 58% of QoL variance. Furthermore, the multi-group analysis revealed that the model was not invariant for both groups. The analysis of the critical ratios showed that the path from weight-related experiential avoidance to QoL was stronger for the BE group. Also the model only explained 39% of QoL for the group without BE and 65% of QoL for the BE group.This study highlights the pervasive role of weigh self-stigma, particularly fear of being discriminated and weight-related experiential avoidance on obesity-related quality-of-life, especially for those women with BE. Additionally, it supports that interventions should focus not only in weight loss but also in improving individual's QoL, promoting the development of adaptive emotional regulation strategies.