The studies on the application of topical preparations are reviewed. The data obtained demonstrate that in most cases the quantities of sunscreens, industrial protective creams and topical medications may differ greatly on different anatomic sites and may also vary due to numerous factors. The data on influencing factors in various studies were partially controversial, therefore a possible study design is suggested to resolve these controversies. It is also suggested that the standard layer thickness of sunscreens, used by standardization authorities to evaluate the sun-protective factor, should be reviewed, due to the evident failure of the majority of sunbathers to comply with the standard layer thickness used now by the ASA (2 mg/m2) or DIN (1.5 mg/m2). It is also important to have a standard of applied amounts of topical medications to be able to compare the effectiveness and bioequivalence of different topical medications precisely. The use of special delivery methods (such as flurandrenolide tape) demonstrates one approach to the standardization of topical treatment dosing.