The Western Australian Family Connections Genealogical Project: Detection of Familial Occurrences of Single Gene and Chromosomal Disorders

Brameld, Kate; Dye, Danielle E.; Maxwell, Susannah; Brisbane, Joanna; Glasson, Emma; Goldblatt, Jack; O’Leary, Peter

doi:10.1089/gtmb.2013.0254

Cited by 3 publications

(3 citation statements)

References 21 publications

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“…This could ultimately contribute to improved screening for familial disorders, and earlier treatment initiation. Centers in other countries, such as Australia, Sweden, and the United Kingdom, have potential to link the administrative healthcare data between first‐degree relatives . Thus the opportunities for validating and expanding our research work are many.…”

Section: Discussionmentioning

confidence: 99%

Objectively Verified Parental Hip Fracture Is an Independent Risk Factor for Fracture: a Linkage Analysis of 478,792 Parents and 261,705 Offspring

Yang

Leslie

Yan

et al. 2016

Journal of Bone and Mineral Research

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Parental hip fracture (HF) is considered a major risk factor for offspring major osteoporotic fracture (MOF), but all studies to date have relied on self-reported information of uncertain accuracy. We tested the association of objectively verified parental HF with offspring MOF and HF. We used a population-based historical cohort study of 261,705 offspring (age ≥40 years) with at least one linked parent (total 478,792 parents) for the province of Manitoba, Canada. Cox proportional hazards models were developed to test hazard ratio (HR) for offspring MOF and HF for 1997 to 2014 according to prior parental HF dating back to 1970. The median age of offspring at study entry was 40 years (range, 40 to 50 years), and 48.3% were women. During 2.9 million person-years of offspring follow-up (median per offspring, 12 years), we identified 7323 incident MOF (4.4% versus 2.7% for those with and without a parental HF, p < 0.001), including 331 HF (0.3% versus 0.1%, p < 0.001). Parental HF was independently associated with increased risk of offspring MOF (HR, 1.30; 95% confidence interval [CI], 1.20 to 1.41). The strength of the association decreased with older parental age at HF (ptrend < 0.001), and was no longer significant if parental HF occurred after age 80 years (adjusted HR, 1.07; 95% CI, 0.96 to 1.19). The relationship between parental HF and offspring HF was even stronger than for MOF (adjusted HR, 1.64; 95% CI, 1.21 to 2.23). Associations with MOF or HF were not affected by either the gender of the parent with HF or the gender of the offspring. Parental HF increased the risk for offspring MOF and HF but not when parental HF occurred after age 80 years. This suggests a more nuanced approach for clinicians trying to stratify fracture risk, and illustrates the enormous potential of parent-offspring record linkage for other familial disorders. © 2016 American Society for Bone and Mineral Research.

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Section: Discussionmentioning

confidence: 99%

Objectively Verified Parental Hip Fracture Is an Independent Risk Factor for Fracture: a Linkage Analysis of 478,792 Parents and 261,705 Offspring

Yang

Leslie

Yan

et al. 2016

Journal of Bone and Mineral Research

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“…In addition to large cohort follow-up, our suggestion for future research is to also use existing large genealogy databases. Several Scandinavian countries, Australia, 32 and the state of Utah in the United States 33 have genealogy databases that include large numbers of people. These databases could be linked to cancer registries and hospital data to identify families with HDGC and determine risk in family members.…”

Section: Randommentioning

confidence: 99%

Outcomes of screening gastroscopy in first-degree relatives of patients fulfilling hereditary diffuse gastric cancer criteria

Post

Dieren

Grelack

et al. 2018

Gastrointestinal Endoscopy

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“…Several information-rich environments and two of the well-known primary data collection efforts (the Framingham Study and the Panel Study of Income Dynamics) (D'Agostino et al, 2008;Johnson & Schoeni, 2011) facilitate making comparisons across generations within the same family. The Family Connections Genealogical Project in Western Australia has actively utilised this capacity and the large N for focused genetic epidemiological research (Brameld et al, 2014). The Danish Family Relations Database has been used to study how a number of diseases cluster in families (Boyd et al, 2009;Oyen et al, 2012).…”

Section: Families and Generationsmentioning

confidence: 99%

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The Western Australian Family Connections Genealogical Project: Detection of Familial Occurrences of Single Gene and Chromosomal Disorders

Cited by 3 publications

References 21 publications

Objectively Verified Parental Hip Fracture Is an Independent Risk Factor for Fracture: a Linkage Analysis of 478,792 Parents and 261,705 Offspring

Objectively Verified Parental Hip Fracture Is an Independent Risk Factor for Fracture: a Linkage Analysis of 478,792 Parents and 261,705 Offspring

Outcomes of screening gastroscopy in first-degree relatives of patients fulfilling hereditary diffuse gastric cancer criteria

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