The Western Dietary Pattern Is Prospectively Associated With Nonalcoholic Fatty Liver Disease in Adolescence

Oddy, Wendy H.; Herbison, Carly E.; Jacoby, Peter; Ambrosini, Gina L.; O’Sullivan, Therese A.; Ayonrinde, Oyekoya T.; Olynyk, John K.; Black, Lucinda J; Beilin, Lawrence J.; Mori, Trevor A.; Hands, Beth; Adams, Leon A.

doi:10.1038/ajg.2013.95

Cited by 239 publications

(247 citation statements)

References 42 publications

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“…Our study shows an increased odd of NAFLD among males and young adults which is supporting some recent findings (Adams et al 2005;Oddy et al 2013), while the protective effect of moderate alcohol drinking is still under debate. Moderate alcohol drinking might have a protective role on the risk of developing NAFLD in view of the (Dunn et al 2008) or through the beneficial effect of high-density lipoprotein (HDL) cholesterol increased levels as for cardiovascular disease (CVD) (Djousse et al 2009).…”

Section: Discussionsupporting

confidence: 91%

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A case–control study on the effect of metabolic gene polymorphisms, nutrition, and their interaction on the risk of non-alcoholic fatty liver disease

et al. 2014

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The oxidative stress is a key issue in the etiology of non-alcoholic fatty liver disease (NAFLD). The aim of our study was to evaluate the effect of metabolic gene polymorphisms involved in the oxidative stress (GSTT1, GSTM1, SULT1A1, CYP2E1, and 1A1), lifestyle and nutrition aspects, and their interaction, on the risk of NAFLD. We enrolled 294 cases and 359 controls, and collected demographics, anthropometric, lifestyle, and nutrition data. A subgroup of NAFLD provided additional data on nutrients and on physical activity engagement. Each patient provided a blood sample for DNA extraction and genotyping. Clinical and laboratory data were collected from cases. Multivariable analysis shows a significant protective effect of age, gender, and moderate drinking habits on the risk of NAFLD, while an increased risk for greater consumption of fruit and grilled meat or fish. Significant interactions were reported between alcohol consumption, fruit intake, grilled meat and fish, and selected genetic variants. From the subgroup analysis, a moderate/high consumption of fat and/or grilled meat/fish, and a high consumption of white meat increase the risk of NAFLD. Engaging any physical activity at least 1 time/ week halves the risk of NAFLD. Besides confirming the beneficial effect of moderate alcohol intake and regular physical activity, and the increased risk associated with high fruit and fat intake, for the first time, we report a detrimental effect of grilled food on NAFLD risk. An effect modification by selected gene variants increases the risk in combination with fruit and grilled food intake.

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Section: Discussionsupporting

confidence: 91%

“…The reports show that most of the observational studies conducted support an increased risk of disease associated with high fat and sugar intake (the so called ''Western'' dietary pattern) (Oddy et al 2013) and a decreased risk associated with physical activity engagement (Zelber-Sagi et al 2011).…”

Section: Discussionmentioning

confidence: 99%

A case–control study on the effect of metabolic gene polymorphisms, nutrition, and their interaction on the risk of non-alcoholic fatty liver disease

et al. 2014

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“…Over-consumption of food rich in fat and carbohydrates causes excess fat accumulation in adipose tissue and liver, and the development of obesity and complications including insulin resistance and nonalcoholic fatty liver disease (NAFLD) [1] [2]. NAFLD can progress to nonalcoholic steatohepatitis (NASH) characterized by hepatocyte ballooning and lobular inflammation.…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory liposomes targeting liver macrophages arrest progression of nonalcoholic steatohepatitis

et al. 2018

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, Immunomodulatory liposomes targeting liver macrophages arrest progression of nonalcoholic steatohepatitis, Metabolism (2017Metabolism ( ), doi: 10.1016Metabolism ( /j.metabol.2017 This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT A C C E P T E D M A N U S C R I P T ACCEPTED MANUSCRIPT ConclusionsLiposomes are a new strategy to target lipid rich inflammatory dendritic cells and have potential to deliver immunomodulatory compounds to treat NASH.

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“…These diseases are the lead cause of morbidity and mortality, affecting millions of people in developed and developing countries [2]. Although factors such as genetic determination, stress, physical inactivity, and smoking are all known to contribute to CVD, unhealthy dietary patterns is one of the most relevant, such as the "western diet" pattern [3].…”

Section: Introductionmentioning

confidence: 99%

“…F Nutr Reprt 1(4): 1-8. doi: https://doi.org/10.24218/fnr. 2017.16. carbohydrates and sodium along with a very low intake of fibers [3][4][5]. Because of that, western diet can increase plasma triglycerides, VLDL-cholesterol hepatic synthesis as well as reduce HDL-cholesterol.…”

Section: Introductionmentioning

confidence: 99%

The Partial Replacement of Lard by Caryocar brasiliense Oil in a Western Diet improves Cardiovascular Risk Factors in Rats

Esteves¹

2017

F Nutr Reprt

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The Western Dietary Pattern Is Prospectively Associated With Nonalcoholic Fatty Liver Disease in Adolescence

Cited by 239 publications

References 42 publications

A case–control study on the effect of metabolic gene polymorphisms, nutrition, and their interaction on the risk of non-alcoholic fatty liver disease

A case–control study on the effect of metabolic gene polymorphisms, nutrition, and their interaction on the risk of non-alcoholic fatty liver disease

Immunomodulatory liposomes targeting liver macrophages arrest progression of nonalcoholic steatohepatitis

The Partial Replacement of Lard by Caryocar brasiliense Oil in a Western Diet improves Cardiovascular Risk Factors in Rats

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