This chapter examines research from psychology of perception and cognition as well as select developments in the visual arts that inspired the design of the split-brain user interface developed for the interactive documentary Anita und Clarence in der Hölle: An Opera for Split-Brains in Modular Parts (Garvey, 2002). This experimental interface aims at ‘enhanced' interaction while creating a new aesthetic experience. This emergent aesthetic might also be described as induced artificial cognitive dissonance and recalls select innovations in the rise of modernism notably the experiments of the Surrealists. The split-brain interface project offers a model for further investigations of human perception, neural processing and cognition through experimentation with the basic principles of stereo and binocular vision. It is conceivable that such an interface could be a design strategy for augmented or virtual reality or even wearable computing. The chapter concludes with a short discussion of potential avenues for further experimentation and development.